A typical clinical and pharmacological article
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..
PHARMACHOLOGIC EFFECT
Combined drug, analgesic, antipyretic, vasodilating, antimigraine. Eliminates the symptoms of colds and flu.
Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance.
Codeine has a central antitussive effect (by suppressing the excitability of the cough center), as well as an analgesic effect caused by excitation of opiate receptors in various parts of the central nervous system, leading to stimulation of the antinociceptive system and changes in emotional perception of pain. To a lesser extent, than morphine, depresses breathing, rarely causes miosis, nausea, vomiting and constipation (activation of opioid receptors in the intestine causes relaxation of smooth muscles, decreased peristalsis and spasm of all sphincters). Strengthens the effect of analgesics.
Paracetamol is a non-narcotic analgesic; blocks COX1 and COX2 mainly in the central nervous system, affecting the centers of pain and thermoregulation; has analgesic and antipyretic effect.
Metamizol - NSAIDs, analgesic, antipyretic, spasmolytic effect on the smooth muscles of the urinary and biliary tract.
Phenobarbital - an antiepileptic agent, has a sedative, hypnotic, spasmolytic and miorelaksiruyuschee action.
The duration of the action is 4-6 hours.
INDICATIONS
Pain syndrome (mild and moderate intensity):
- Arthralgia;
- myalgia;
- neuralgia;
- ischialgia;
- Migraine;
- dental and headache;
- algodismenorea;
- pain with injuries, burns;
- febrile syndrome (including with ARVI).
DOSING MODE
Inside, 1 tab; if necessary - 1 tab. 4 times / day; the maximum single dose is 2 tablets, daily - 6 tablets. The course of treatment is up to 5 days.
SIDE EFFECT
Allergic reactions (rash, itching, urticaria), dizziness, drowsiness, decreased speed of psychomotor reactions, palpitation, tachycardia, nausea, vomiting, constipation;leukopenia, granulocytopenia, agranulocytosis.
With prolonged uncontrolled admission in high doses - addiction (weakening analgesic effect), drug dependence (codeine); impaired liver and / or kidney function.
CONTRAINDICATIONS
hypersensitivity;
- severe hepatic and / or renal insufficiency;
- deficiency of glucose-6-phosphate dehydrogenase;
- Anemia;
- Lakopenia;
- bronchial asthma;
- conditions accompanied by respiratory depression;
- intracranial hypertension;
acute myocardial infarction;
- arrhythmia;
- alcoholic intoxication;
- glaucoma;
- Pregnancy;
- lactation period;
- Children's age (up to 12 years).
With caution: with gastric ulcer and 12 duodenal ulcer (in the acute stage), hypertension, elderly patients.
PREGNANCY AND LACTATION
Contraindicated in pregnancy, during lactation.
APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in severe renal failure.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated in severe hepatic insufficiency.
APPLICATION FOR CHILDREN
Contraindicated in children under 12 years.
APPLICATION IN ELDERLY PATIENTS
With caution to elderly patients.
SPECIAL INSTRUCTIONS
With prolonged (more than 1 week) treatment, monitoring of the peripheral blood picture and the functional state of the liver is necessary.
Can change the results of tests of doping control athletes.
It is difficult to establish a diagnosis with an "acute abdomen".
In patients with atopic bronchial asthma, pollinosis, there is an increased risk of allergic reactions.
During treatment, you should stop using ethanol and take care when driving vehicles and engage in other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.
OVERDOSE
Symptoms: nausea, vomiting, gastralgia, tachycardia, arrhythmias, oppression of the respiratory center.
Treatment: gastric lavage, intestinal adsorbent administration, symptomatic therapy.
DRUG INTERACTION
With the simultaneous use of drugs that depress the central nervous system (including sedatives and anxiolytics), it is likely that the severity of the sedative effect and the oppressive effect on the respiratory center will increase.
Increases the effect of ethanol on the psychomotor response.
Metamizole reduces the concentration of cyclosporine. Omitting oral hypoglycemic drugs, indirect anticoagulants, GCS and indomethacin out of association with the protein, increases their activity.
Tricyclic antidepressants, oral contraceptives and allopurinol disrupt metamizole metabolism in the liver and increase its toxicity.
Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole.
Simultaneous use of the drug with other non-narcotic analgesics may lead to an increase in toxic effects.
