Universal reference book for medicines
Name of the preparation: RIBOFLAVIN-MONONUCLEOTIDE (RIBOFLAVIN-MONONUCLETIDE)

Active substance: riboflavin

Type: Vitamin B

Manufacturer: FARMSTANDART-UFIM VITAMIN FACTORY (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Vitamin B 2 .
Regulating the oxidation-reduction processes, takes part in protein, fat and carbohydrate metabolism, as well as in maintaining the normal visual function of the eye and the synthesis of hemoglobin.
PHARMACOKINETICS
Riboflavin and its nucleotides are rapidly absorbed from the digestive tract.
Chronic gastritis, enteritis, achilles slow absorption. Unevenly distributed in the organs and tissues of the body: the largest number - in the myocardium, liver, kidneys. Binding to plasma proteins - 60%. Penetrates through the placental barrier, excreted in breast milk. It is excreted by the kidneys.
INDICATIONS
Hypo-and avitaminosis B 2 , hemorrhagia, conjunctivitis, keratitis, iritis, corneal ulcer, cataracts, long-lasting non-healing wounds and ulcers, general eating disorders, radiation sickness, asthenia, intestinal dysfunction, hepatitis.

DOSING MODE
Single dose - 5-10 mg, for children - 2-5 mg 1-3 times / day for 1-1.5 months.

SIDE EFFECT
Possible: allergic reactions, impaired renal function, impaired vision.

CONTRAINDICATIONS
Hypersensitivity to riboflavin, nephrolithiasis.

PREGNANCY AND LACTATION
Perhaps the use of riboflavin during pregnancy and lactation (breastfeeding) according to the indications.

SPECIAL INSTRUCTIONS
Stains urine in a light yellow color.

DRUG INTERACTION
At simultaneous application with m-holinoblokatorami absorption and bioavailability of riboflavin increases (due to decrease of peristalsis of the intestine).

With simultaneous use with thyroid hormones, metabolism of riboflavin is accelerated.

With simultaneous use decreases the activity of doxycycline, tetracycline, oxytetracycline, erythromycin and lincomycin.

Riboflavin is not compatible with streptomycin.

With simultaneous use, the side effects of chloramphenicol are reduced and prevented (violation of hemopoiesis, optic neuritis).

With the simultaneous use of chlorpromazine, amitriptyline due to blockade of flavinokinase disrupt the incorporation of riboflavin into flavinadenine mononucleotide and flavinadenine dinucleotide and increase its excretion in the urine.

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