A typical clinical and pharmacological article
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..
PHARMACHOLOGIC EFFECT
Enzyme preparation, obtained from the pancreas of cattle. Depolymerizes RNA to acid-soluble mono- and oligopeptides. Liquefies pus, mucus, viscous and thick sputum; has anti-inflammatory effect. Destroying nucleic acids, delays the reproduction of some RNA-containing viruses.
The activity of ribonuclease is determined by the biological method according to the amount of acid-soluble substances released as a result of hydrolysis of RNA under certain conditions. One unit of activity (EA) corresponds to 1 mg of the drug.
INDICATIONS
- Diseases of the respiratory tract with viscous hard-to-detachable sputum (bronchiectatic disease, lung abscesses, lung atelectasis, exudative pleurisy);
- Parodontosis;
- gingivitis;
- osteomyelitis;
- fistulas;
- abscesses;
- trophic ulcers;
- sinusitis (acute and exacerbation of chronic);
- Otitis (acute and exacerbation of chronic, including in the perforated stage);
- thrombophlebitis;
- tick-borne encephalitis (in severe disease, in combination with a specific gamma globulin);
- Viral meningitis.
DOSING MODE
When topical application, the wound or ulcerous surface is sprinkled with powder in the amount of 25-50 mg and napkins or tampons moistened with the solution of the preparation in a 0.9% solution of sodium chloride are applied.
For inhalations use a finely dispersed aerosol - 25 mg per 1 procedure (for this, the drug is dissolved in 3-4 ml of 0.9% sodium chloride solution or in 0.5% solution of procaine).
Endobronchially enter a solution containing 25-50 mg, using a laryngeal syringe or catheter.
Intrapleural - 25-50 mg in 5-10 ml of a 0.9% solution of sodium chloride or 0.2% solution of procaine.
With sinusitis - 5-10 mg in 3-5 ml of 0.9% solution of sodium chloride in the maxillary (maxillary) sinus after puncture and rinsing; with otitis - 0.1% solution (0.5-1 ml) in the external ear canal.
In / m injected 5-10 mg in 1 ml of a 0.9% solution of sodium chloride or 0.5% solution of procaine; course of treatment - 2-10 injections, 1-2 injections per day.
The maximum single dose for intravenous injection - 10 mg, with local and intracavitary injection - 50 mg.
For the treatment of tick-borne encephalitis - in / m, 6 times / day, in a single dose - 25-30 mg; children 1-3 years - 5-8 mg (depending on body weight), 4-6 years - 10-14 mg, 7-11 years - 15-18 mg, 12-15 years - 20 mg.
The necessary amount of the drug is dissolved before injection in 2 ml of 0.25-0.5% solution of procaine. Before the beginning of treatment, samples for sensitivity to the drug are carried out: 0.1 ml is injected onto the flexor surface of the forearm; Therapy is carried out in the absence of a local and general reaction.
SIDE EFFECT
Irritation of the mucous membranes of the respiratory tract, allergic reactions.
CONTRAINDICATIONS
hypersensitivity;
- chronic heart failure II-III stages;
- respiratory insufficiency;
- liver failure;
- tuberculosis (open form);
bleeding.
With caution: empyema of the pleura (tuberculous etiology).
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindication is liver failure.
APPLICATION FOR CHILDREN
The application is possible according to the dosing regimen.
SPECIAL INSTRUCTIONS
Degradation of exudate with empyema of the pleural tubercle aetiology can promote the development of bronchopleural fistula.
