Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..
PHARMACHOLOGIC EFFECT
Antiviral agent, adamantane derivative. The main mechanism of antiviral action is the inhibition of the early stage of specific reproduction after the virus enters the cell and before the initial transcription of RNA. Pharmacological effectiveness is provided by inhibiting the reproduction of the virus in the initial stage of the infectious process.
It is active against various strains of influenza A virus (especially A2 type), as well as viruses of tick-borne encephalitis (Central European and Russian spring-summer), which belong to the group of arboviruses of the Flaviviridae family.
PHARMACOKINETICS
After ingestion slowly, almost completely absorbed in the intestine. Binding to plasma proteins is about 40%. V d in adults - 17-25 l / kg, in children - 289 l.Concentration in nasal secretion is 50% higher than plasma concentration. The value of C max with the intake of 100 mg 1 time / day - 181 ng / ml, 100 mg 2 times / day - 416 ng / ml. Metabolised in the liver. T 1/2 - 24-36 h; is excreted by the kidneys (15% in unchanged form, 20% in the form of hydroxyl metabolites). In chronic renal failure T 1/2 increases by 2 times. In persons with renal insufficiency and in elderly people, it can accumulate in toxic concentrations if the dose is not corrected in proportion to the decrease in QC.
INDICATIONS
Prevention and early treatment of influenza in adults and children older than 7 years, the prevention of influenza in the period of epidemics in adults, the prevention of tick-borne encephalitis of viral etiology.
DOSING MODE
Individual, depending on the indications, the age of the patient and the treatment regimen used.
SIDE EFFECT
From the digestive system: pain in epigastrium, flatulence, increased bilirubin level in the blood, dry mouth, anorexia, nausea, vomiting, gastralgia.
From the side of the central nervous system: headache, insomnia, nervousness, dizziness, impaired concentration, drowsiness, anxiety, increased excitability, fatigue.
Other: allergic reactions.
CONTRAINDICATIONS
Acute liver disease, acute and chronic kidney disease, thyrotoxicosis, pregnancy, children under 7 years of age, hypersensitivity to rimantadine.
PREGNANCY AND LACTATION
Contraindicated in pregnancy.
APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in acute and chronic kidney disease.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated in acute liver diseases.
APPLICATION FOR CHILDREN
Contraindicated in children under 7 years.
APPLICATION IN ELDERLY PATIENTS
In elderly patients with hypertension, the risk of hemorrhagic stroke increases.
SPECIAL INSTRUCTIONS
With caution apply rimantadine in arterial hypertension, epilepsy (including in the anamnesis), atherosclerosis of cerebral vessels.
With the use of rimantadine, an exacerbation of chronic comorbidity may occur. In elderly patients with hypertension, the risk of hemorrhagic stroke increases. With a history of epilepsy and anticonvulsant therapy, the risk of epileptic seizure increases with rimantadine. In such cases, rimantadine is used in a dose up to 100 mg / day simultaneously with anticonvulsant therapy.
With influenza caused by virus B, rimantadine exerts an antitoxic effect.
Prophylactic reception is effective at contacts with the sick, with the spread of infection in closed collectives and at a high risk of the disease during the flu epidemic.Perhaps the emergence of drug-resistant viruses.
DRUG INTERACTION
With simultaneous application of rimantadine reduces the effectiveness of antiepileptic drugs.
Adsorbents, astringents and enveloping agents reduce the absorption of rimantadine.
Means, acidifying urine (ammonium chloride, ascorbic acid), reduce the effectiveness of rimantadine (due to increased its excretion by the kidneys).
Means, alkalizing urine (acetazolamide, sodium bicarbonate) enhance its effectiveness (decreased excretion by the kidneys).
Paracetamol and acetylsalicylic acid reduce C max rimantadine by 11%.
Cimetidine reduces the clearance of rimantadine by 18%.
