A typical clinical and pharmacological article
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..
PHARMACHOLOGIC EFFECT
Combined drug, the effect of which is due to its constituent components; anti-inflammatory, anti-edematous, antiallergic, vasoconstrictive, antiproliferative, immunosuppressive, keratolytic, antimicrobial, antifungal and local hypothermic. It inhibits the release of mediators of inflammation, prevents the accumulation of neutrophils, reduces inflammatory exudate and production of cytokines, reduces the migration of macrophages, leading to a decrease in infiltration and granulation.
Due to the presence of salicylic acid softens the skin, eliminates horny layers and promotes deeper penetration of the GCS.
Ointment has a water repellent effect and forms a protective film, protecting the skin from the effects of external moisture; possessing a deep fat-free effect, is most suitable for the treatment of patients with dry and fragile skin.
Lotion (a solution in a fat-free basis) is easily distributed on the surface of the skin, does not adhere or dry the hair, leaves no visible traces, has a cooling effect on the skin.
INDICATIONS
- psoriasis;
- eczema (especially chronic);
ichthyosis;
- limited pruritus with severe lichenization;
- atopic dermatitis;
- diffuse neurodermatitis;
- simple and allergic dermatitis;
- hives;
- multiforme exudative erythema;
- simple chronic lichen (limited neurodermatitis);
- dermatoses that are not amenable to treatment by other SCS (especially red warty lichen);
- Red flat lichen;
skin dyshidrosis.
DOSING MODE
External, on the affected areas, slightly rubbing, apply a thin layer 2-3 times / day. If necessary, occlusal dressings are applied, which are changed every 24 hours (because of the delay in the evaporation of sweat and dermal respiration, a moist chamber is created that facilitates loosening of the stratum corneum and accelerated, deeper penetration of the drug - about 100 times greater than when applied simply).
The course of treatment is up to 3 weeks. If you need long-term treatment, apply less often - every other day. In the treatment of chronic diseases, treatment should continue for some time after the disappearance of all symptoms to avoid relapse of the disease.
SIDE EFFECT
Burning, irritation, dryness, hypopigmentation, skin itching, folliculitis, hypertrichosis, acne.
When applying occlusive dressings - maceration of the skin, striae, skin atrophy, secondary infection, sweating.
With long-term use - skin atrophy, local hirsutism, telangiectasia, purpura, hypopigmentation, hypertrichosis.
When applied to large areas - systemic manifestations of side effects of SCS (growth retardation, Itenko-Cushing syndrome, benign increase in intracranial pressure after treatment, hyperglycemia, glucosuria, hypokalemia, increased blood pressure) or salicylates (pallor, fatigue, drowsiness, hyperventilation in the background tachypnea, nausea, vomiting, hearing impairment, confusion).
CONTRAINDICATIONS
hypersensitivity;
- bacterial, viral and fungal skin diseases (pyoderma, syphilis, skin tuberculosis, chicken pox, herpes, actinomycosis, blastomycosis, sporotrichosis);
- postvaccinal skin reactions;
- perioral dermatitis;
- rosacea;
- trophic ulcers on the background of chronic venous insufficiency;
- skin tumors (skin cancer, nevus, atheroma, epithelioma, melanoma, hemangioma, xanthoma, sarcoma);
- Pregnancy;
- the period of lactation (do not apply to the skin of the breast before feeding);
- Children's age up to 1 year.
With caution : hepatic insufficiency, children's age (over 1 year), long-term therapy, especially with the use of occlusive dressings.
PREGNANCY AND LACTATION
Contraindications: pregnancy; lactation period (do not apply to the skin of the breast before feeding).
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
C with caution : hepatic insufficiency.
APPLICATION FOR CHILDREN
Contraindication - children under 1 year.
With caution : children's age (over 1 year).
The use of ointment in children should be as short as possible (the risk of systemic absorption is proportional to the greater number of active components due to the prevalence of skin area over body weight and insufficient maturity of the epidermis).
SPECIAL INSTRUCTIONS
Avoid contact with the eyes, do not apply to the skin near the eyes and mucous membranes.
It is not recommended for long-term use on the skin of a person - it is possible to develop dermatitis by the type of rosacea, perioral dermatitis, atrophy of the skin and acne; avoid application in the anogenital area.
The use of ointment in children should be as short as possible (the risk of systemic absorption is proportional to the greater number of active components due to the prevalence of skin area over body weight and insufficient maturity of the epidermis).
When there are signs of allergic reactions or local irritation, treatment should be stopped.
OVERDOSE
Symptoms: secondary adrenal insufficiency, hypercorticism, Cushing's syndrome.
Treatment: symptomatic.
