Universal reference book for medicines
Name of the drug: OCUMETHYL

Active substance: diphenhydramine, naphazoline, zinc sulfate

Type: The drug with antiallergic and vasoconstrictive action for topical application in ophthalmology

Manufacturer: NORTON (Russia) manufactured by Alexandria Company for Pharmaceuticals and Chemical Industries (Egypt)
Composition, form of production and packaging
Drops of the eye
in the form of a transparent liquid of blue color.

1 ml

Diphenhydramine hydrochloride 1 mg

naphazoline hydrochloride 1 mg

zinc sulfate 1 mg

Excipients: sodium citrate 14 mg, citric acid 0.6 mg, benzalkonium chloride 0.2 mg, dye blue methylene 0.03 mg, sodium chloride 3.2 mg, hypromellose 4000 0.25 mg, sodium hydroxide 0.3 mg, distilled water up to 1 ml.

5 ml - a vial of a dropper plastic (1) - packs cardboard.

10 ml - a vial of a dropper plastic (1) - packs cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2014.


Okumil is a combined preparation containing zinc sulfate, diphenhydramine and
Zinc sulfate, when applied topically, has astringent, drying, anti-inflammatory and antiseptic effects.

Nafazoline is a sympathomimetic.
Has a rapid, pronounced and prolonged vasoconstrictive effect. With topical application reduces swelling and flushing of the mucous membranes.
Diphenhydramine - blocker of H 1 -gistamine receptors.
With topical application reduces the permeability of capillaries and prevents swelling of the tissues.
Thus, Okumil has antiseptic, anti-allergic and anti-inflammatory effects.


When topical application is subjected to systemic absorption.
Information on the degree of penetration into various tissues of the eye after topical application is not present.

- chronic nonspecific conjunctivitis and blepharoconjunctivitis;

- allergic conjunctivitis and blepharoconjunctivitis;

- angular conjunctivitis;

- Reduction of symptoms of irritation of eye tissues (redness, itching, sensation of foreign body).


If there are no other prescriptions of the doctor, then instill 1 drop into the conjunctival sac of the affected eye (eyes) 2-3 times a day.
If during the application of the drug within 72 hours there is no reduction in symptoms, you should stop using the drug and consult a doctor.


After instillation there may be a feeling of slight burning, blurring of vision, development of allergic reactions.
With aphakia, it is possible to develop maculopathy and the emergence of a central scotoma. In this case, the withdrawal of the drug leads to the reverse development of symptoms.
After topical use of naphazoline, which is part of Okumetil, reactive hyperemia and edema of the mucous membrane of the eyes, dilatation of the pupil, an increase in IOP (intraocular pressure) may occur.
With prolonged use, the phenomenon of tissue irritation occurs most often.
Since with topical application of naphazoline has a generalized effect, it is possible to develop tachycardia, increased blood pressure, nausea, headache.

With topical application of diphenhydramine, it is possible to develop side effects, both local and systemic: paresis of accommodation, photosensitivity, dryness and numbness of the mucous membrane of the eyes, drowsiness, weakness, decreased psychomotor reactions and impaired coordination of movements,
With prolonged use of zinc salts, the appearance of dry eye mucosa may occur.


- hypersensitivity to the components of the drug;

- an angle-closure glaucoma;

- dry eye syndrome;

- Pregnancy;

- lactation;

- hyperplasia of the prostate, stenosing ulcer of the stomach and duodenum, stenosis of the neck of the bladder;

- bronchial asthma;

- epilepsy;

- cardiovascular diseases (IHD, arterial hypertension);

- pheochromocytoma;

- Hyperfunction of the thyroid gland;

- diabetes;

- severe atherosclerosis;

- Children's age up to 2 years.

Apply with caution in patients taking MAO inhibitors or other drugs that increase blood pressure.


To avoid contamination of the solution, keep the bottle tightly closed and avoid touching the tip of the pipette with any surface.

Impact on the ability to drive vehicles and manage mechanisms

Within 10-15 minutes after installation, visual acuity can be reduced, so care must be taken when driving the car and when working with mechanisms.


Data on drug overdose are absent.


Since it is possible to reduce the effects of diphenhydramine and medications that stimulate the central nervous system, the use of Okumetil in patients using these drugs is not recommended.

Ocumethyl should not be applied concomitantly with MAO inhibitors and within 10 days after discontinuation of their intake.
As a result of the joint application of beta-blockers, MAO inhibitors with adrenomimetics, the effect of the latter increases.
Nafazolin slows the absorption of local anesthetics, therefore it is not recommended to use the drug Ocumethyl together with local anesthetics used in ophthalmology.

Zinc sulfate is pharmaceutically incompatible with salts of silver, lead, quinine, ichthyol, citral, protargol, alkaline-reacting substances.


Without recipe.


List B. At a temperature of 15-25 В° C, in a place protected from light.
Keep in places inaccessible to children. Shelf life - 3 years.
After opening the bottle should be used within 1 month.

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