Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..
PHARMACHOLOGIC EFFECT
Means containing inorganic iodine. When iodides enter the epithelial cells of the follicle of the thyroid gland under the influence of the iodide-peroxidase enzyme, iodine oxidation occurs with the formation of elemental iodine, which is incorporated into the tyrosine molecule. In this case, one part of the tyrosine radicals in thyroglobulin is iodinated. Iodinated tyrosine radicals condense into tyronines, the main of which are thyroxine (T 4 ) and triiodothyronine (T 3 ). The resulting complex of thyronin and thyroglobulin is released as a deposited form of the thyroid hormone into the colloid of the follicle and remains in this state for several days or weeks. With iodine deficiency, this process is disrupted. Potassium iodide, compensating for iodine deficiency, helps restore the broken synthesis of thyroid hormones.
With the normal content of iodine in the environment, the excess of iodides is inhibited by the biosynthesis of thyroid hormones, their release from thyroglobulin, the sensitivity of the thyroid gland to the thyroid-stimulating hormone of the pituitary gland decreases, and its secretion by the pituitary gland is blocked.
PHARMACOKINETICS
When ingested quickly absorbed from the digestive tract. Widely distributed in all tissues and body fluids.
INDICATIONS
Prophylaxis and treatment of endemic goiter. Prevention of recurrence of goiter in the period of complex treatment with drugs of thyroid hormones.
DOSING MODE
Individual. The daily dose in terms of iodine is 50-100 micrograms for children, 100-200 micrograms for adolescents and adults.
SIDE EFFECT
Manifestations of iodism: edema of the nasal mucosa, urticaria, Quincke's edema, eosinophilia, shock; tachycardia, irritability, sleep disturbances, increased sweating, diarrhea (in patients older than 40 years); in some cases, when used in doses exceeding 300-1000 Ојg / day, the development of hyperthyroidism is possible (especially in elderly patients, with nodular or diffuse toxic goiter); with high-dosage therapy (more than 1 mg / day) may cause iodine-induced goiter and, accordingly, hypothyroidism.
CONTRAINDICATIONS
Expressed hyperthyroidism, latent hyperthyroidism (when applied at doses exceeding 150 mcg / day), toxic adenoma, nodal or diffuse toxic goiter (when used at doses of 300-1000 Ојg / day), herpetiform dermatitis (DГјhring's disease), pregnancy and breastfeeding (when used in doses of 1-2 mg / day), hypersensitivity to iodine preparations.
PREGNANCY AND LACTATION
In pregnancy, use is only possible in recommended doses, because iodine penetrates the placental barrier and can cause hypothyroidism and goiter in the fetus.
Iodine is excreted in breast milk. When used in the mother during lactation (breastfeeding) at doses of more than 1 mg / day, there is a risk of developing hypothyroidism in an infant.
APPLICATION FOR FUNCTIONS OF THE LIVER
On the background of therapy in patients with renal insufficiency, it is possible to develop hyperkalemia.
SPECIAL INSTRUCTIONS
On the background of therapy in patients with renal insufficiency, it is possible to develop hyperkalemia.
DRUG INTERACTION
With simultaneous high-dose therapy with iodine and potassium-sparing diuretics, hyperkalaemia may develop, with lithium preparations - goitre and hypothyroidism. Perchlorate and thiocyanate competitively inhibit the absorption of iodine by the thyroid gland, and TTG - stimulates.
Antithyroid drugs weaken the effect (mutually).
