Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..
PHARMACHOLOGIC EFFECT
Means of plant origin. Contains anthracene derivatives - mainly hypericin, pseudo-hypericin; flavonoids - hyperoside, quercetin, rutin, isokvetsitin, amentoflavone;xanthones - 1,3,6,7-tetrahydroxy-xanthone; acyl chloro-glucinols: hyperforin with small amounts of adhyperforin; essential oils; oligomers; procyanidins and other catechin tannins; derivatives of caffeic acid, including chlorogenic acid.
Has mild antidepressant, sedative and anxiolytic effect, as well as a stimulating effect on the digestive system, blood circulation, a general tonic effect.
It is believed that the antidepressant effect of the plant is due to the ability of its active substances to inhibit the reuptake of serotonin and other neurotransmitters, as well as the effect on melatonin metabolism.
Due to the high content of flavonoids, the plant has an anti-inflammatory effect. Hyperforin has been shown to inhibit the growth of Gram-positive bacteria Streptococcus pyogenes and Streptococcus agalactiae. The effectiveness of hyperforin against penicillin-resistant strains and methicillin-resistant strains of Staphylococcus aureus is shown.
INDICATIONS
Symptomatic and reactive depression, anxiety, sleep disorders. As an additional remedy for endogenous depression (especially in the climacteric period), as well as in diseases of the lungs, stomach, intestines, gall bladder.
Outer: as an additional remedy for joint and muscle pain, as well as for hemorrhages and herpes zoster; for disinfection of wounds.
DOSING MODE
Individual, depending on the indications and the dosage form used.
SIDE EFFECT
When used in recommended doses according to indications, side effects were not revealed. You can not exclude the appearance of a feeling of fullness of the stomach, constipation, photosensitivity.
CONTRAINDICATIONS
Hypersensitivity to biologically active components of St. John's wort, simultaneous use of MAO inhibitors.
PREGNANCY AND LACTATION
Use with caution in pregnancy.
SPECIAL INSTRUCTIONS
It is suggested that St. John's wort in high concentrations can damage reproductive cells.
DRUG INTERACTION
With simultaneous use with MAO inhibitors, it is possible to intensify the effects and develop a hypertensive crisis.
With simultaneous application of St. John's wort, it can significantly affect the concentration in the blood plasma of any drugs metabolized with the participation of enzymes of the cytochrome P450 system.
With simultaneous use with digoxin, a decrease in the efficiency of digoxin is possible, and after stopping the intake of St. John's wort, an increase in the toxicity of digoxin.
With simultaneous use of tannic acids, which are present in St. John's Wort, can inhibit the absorption of iron.
There is a report on the development of acyclic hemorrhage with simultaneous application of St. John's wort with oral contraceptives containing a combination of ethinyl estradiol and levonorgestrel.
With simultaneous application of St. John's wort reduces the concentration of theophylline in the blood plasma in patients who regularly receive theophylline.
With simultaneous application with fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, effects may be enhanced and the development of serotonin syndrome (increased sweating, tremor, redness, confusion, agitation).
With simultaneous application with cyclosporine, a decrease in the concentration of cyclosporine in the blood plasma is possible.
