Universal reference book for medicines
Product name: MAGNELIS ® B6 (MAGNELIS B6)

Active substance: magnesium lactate, pyridoxine

Type: A drug that replenishes magnesium deficiency in the body

Manufacturer: FARMSTANDART-UfaVITA (Russia)
Composition, form of production and packaging
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The tablets covered with a cover of white or almost white color, round, biconcave.
1 tab.

magnesium lactate 470 mg

pyridoxine hydrochloride 5 mg

Excipients: sucrose, povidone (kollidon 30), kollidon SR (polyvinyl acetate, povidone, sodium lauryl sulfate, silicon dioxide), magnesium stearate, carmellose sodium (sodium carboxymethylcellulose), talc.

Composition of the shell: sucrose, kaolin (white clay), gelatin, acacia gum (gum arabic), beeswax white, carnauba wax, talc, titanium dioxide.

10 pieces.
- packings cellular planimetric (3) - packs cardboard.
10 pieces.
- packings cellular planimetric (5) - packs cardboard.
60 pcs.
- polymer cans (1) - packs of cardboard.
90 pcs.
- polymer cans (1) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

A drug that replenishes magnesium deficiency.

Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells.
Participates in most metabolic reactions, in the regulation of nerve impulse transmission and in muscle contraction, has antispasmodic, antiarrhythmic and antiaggregant effects.
The body gets magnesium along with the food.
The lack of magnesium in the body can be observed with a violation of diet (diet) or with increasing demand for magnesium (with increased physical and mental stress, stress, pregnancy, the use of diuretics).
Pyridoxine (vitamin B 6 ) is involved in many metabolic processes, in the regulation of the metabolism of the nervous system.
Improves the absorption of magnesium from the digestive tract and its penetration into the cells.
Magnesium content in the serum from 12 to 17 mg / l (0.5-0.7 mmol / l) indicates a moderate magnesium deficiency;
below 12 mg / l (0.5 mmol / l) - about severe magnesium deficiency.
PHARMACOKINETICS

Suction

After taking the drug inward, the absorption of magnesium from the digestive tract is 50%.

Excretion

It is excreted mainly by the kidneys.
In the kidneys after the glomerular filtration of 70% of the magnesium present in the plasma, its reabsorption in the renal tubules is 95-97%.
INDICATIONS

- established magnesium deficiency, isolated or associated with other deficient states.

DOSING MODE

Adults are recommended to prescribe 6-8 tablets / day.
Children older than 6 years (body weight over 20 kg) - 4-6 tablets / day. The daily dose should be divided into 2-3 divided doses.
Treatment should be discontinued after the normalization of the magnesium concentration in the blood.

The drug should be taken with food, washed down with a glass of water.

SIDE EFFECT

From the digestive system: abdominal pain, constipation, nausea, vomiting, flatulence.

Allergic reactions: allergic reactions are possible.

CONTRAINDICATIONS

- renal failure of severe degree (QC less than 30 ml / min);

- phenylketonuria;

- children's age till 6 years;

- Hypersensitivity to the components of the drug.

With caution should be used in patients with moderate renal insufficiency, t.
there is a risk of hypermagnesemia.
PREGNANCY AND LACTATION

Clinical experience has not revealed fetotoxic or teratogenic effects of the drug.

Magnelis ® B6 can be used during pregnancy only as directed by a doctor.

Magnesium penetrates excreted in breast milk.
Avoid the use of the drug during lactation and breastfeeding.
APPLICATION FOR FUNCTIONS OF THE LIVER

With caution should be used in patients with moderate renal insufficiency, t.
there is a risk of hypermagnesemia.
Contraindicated in patients with severe renal failure (CC less than 30 ml / min).

APPLICATION FOR CHILDREN

Contraindication: children under 6 years.

SPECIAL INSTRUCTIONS

If it is necessary to use the drug in patients with diabetes mellitus, it should be borne in mind that the tablets contain sucrose as an auxiliary substance.

In case of concomitant calcium deficiency, magnesium deficiency should be eliminated before calcium intake is started.

OVERDOSE

With normal kidney function, magnesium ingestion does not cause toxic reactions.
Magnesium poisoning can develop with kidney failure. Toxic effects mainly depend on the magnesium content in the blood serum.
Symptoms: falling AD, nausea, vomiting, slowing reflexes, anuria, respiratory depression, coma, cardiac arrest.

Treatment: rehydration, forced diuresis.
With renal failure, hemodialysis or peritoneal dialysis is necessary.
DRUG INTERACTION

With the simultaneous use of drugs containing phosphates or calcium salts, a significant reduction in the absorption of magnesium from the digestive tract is possible.

Magnesium preparations reduce the absorption of tetracycline, it is recommended to divide the intake of these drugs in a 3-hour interval.

Magnesium reduces the effect of oral thrombolytic agents, reduces the absorption of iron.

Vitamin B 6 inhibits the activity of levodopa.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of the reach of children, protected from light at a temperature of no higher than 25 ° C.
Shelf life - 2 years.
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