Universal reference book for medicines

Active substance: magnesium citrate, pyridoxine

Type: A drug that replenishes magnesium deficiency in the body

Composition, form of production and packaging
? The tablets covered with a film membrane of white color, oblong, biconcave; on a cut of white or almost white color.
1 tab.

magnesium citrate 618.43 mg,

which corresponds to the magnesium content (Mg 2+ ) of 100 mg

pyridoxine hydrochloride 10 mg

Auxiliary substances: ludistress ® -101.21 mg (lactose - 92.2 mg, povidone K30 (kollidone K30) - 3.04 mg-4.05 mg, crospovidone (collidone CL) - 3.04 mg-4.05 mg), macrogol 6000 (polyethylene glycol 6000) - 69.36 mg, magnesium stearate - 1 mg.

The composition of the coating: VIVACOAT ® PM-1P-000 - 20 mg (hypromellose 6 cps (hydroxypropyl methylcellulose 6 cps) - 10 mg, titanium dioxide - 6 mg, giprolose (hydroxypropyl cellulose) - 1 mg, talc - 2 mg, macrogol-3350 (polyethylene glycol -3350) -1 mg).

10 pieces.
- Packings contour mesh (3) - packs cardboard.
10 pieces.
- packings contour mesh (6) - packs cardboard.
10 pieces.
- Packings contour mesh (9) - packs cardboard.

Description of the drug approved by the manufacturer for the printed edition of 2016.



Magnesium is a vital element that is necessary for the normal functioning of cells, is involved in most metabolic reactions.
In particular, it is involved in the regulation of the transmission of nerve impulses and in muscle contraction. 50% of the amount of magnesium contained in the body accumulates in bone tissue.
Pyridoxine (vitamin B 6 ) is involved in many metabolic processes, improves absorption of magnesium from the digestive tract and its penetration into cells.

Concentration of magnesium in serum:

- between 12 and 17 mg / l (1-1.4 mEq / L or 0.5-0.7 mmol / L): indicates a moderate deficiency of magnesium;

- below 12 mg / l (1 mEq / L or 0.5 mmol / L): indicates a severe magnesium deficiency.

The body gets magnesium along with the food.
The lack of magnesium in the body can be observed with a deficiency in the intake or with an increase in the demand for magnesium.

Gastrointestinal absorption of magnesium salts occurs in part by a passive mechanism in which salt solubility plays a decisive role.
The degree of this absorption does not exceed 50%. Excretion occurs mainly by the kidneys.

- established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as increased irritability, minor sleep disorders, gastrointestinal spasms, palpitations, fatigue, pain and muscle spasms, tingling sensations in the muscles.

If after a month of treatment there is no decrease in these symptoms, continued treatment is not appropriate.


Tablets should be taken whole, washed down with a glass of water.

Adults : 3-4 tablets / day, divided into 2-3 meals, with meals.

Children over the age of 12 years: 2-4 tablets / day, divided into 2-3 sessions, with meals.

Usually the duration of treatment is 1 month.


The frequency of adverse reactions is classified according to the recommendations of the World Health Organization: very often (? 10%), often (? 1% and <10%), infrequently (? 0.1% and <1%), rarely (? 0.01% and <0.1% ), very rarely (<0.01%), an unknown frequency (when it is not possible to estimate the incidence of adverse reactions by available data).

From the immune system: very rarely (<0.01%) - allergic reactions, including skin reactions.

From the gastrointestinal tract: an unknown frequency (according to available data to estimate the frequency of occurrence is not possible) - diarrhea, abdominal pain, nausea, vomiting, flatulence.


- hypersensitivity to any of the components of the drug;

- severe renal failure (CC less than 30 ml / min);

- age up to 12 years (efficiency and safety not established);

- hereditary galactosemia, glucose malabsorption syndrome and galactose or lactase deficiency (due to the presence of lactose monohydrate in the formulation);

- simultaneous reception of levodopa (see "Drug Interactions").


Moderate renal failure (risk of hypermagnesemia).



The clinical experience of using a combination of magnesium citrate and pyridoxine hydrochloride in a sufficient number of pregnant women has not revealed any adverse effect on the onset of fetal developmental or fetotoxic effects.
Magnelis preparation At 6 forte, film-coated tablets can be used during pregnancy only if necessary, on the recommendation of a doctor.
Breastfeeding period

Taking into account that magnesium penetrates into the mother's milk, it is recommended to stop breastfeeding if necessary.


With caution apply the drug to patients with moderate renal failure (the risk of hypermagnesemia).

Contraindicated the use of the drug in patients with severe renal failure (CC less than 30 ml / min).


Contraindicated use of the drug for children under the age of 12 years (efficacy and safety not established).


Preparation Magnelis B 6 forte, film-coated tablets is intended only for adults and children over 12 years of age.

The drug contains lactose monohydrate, therefore its use is not recommended for patients with hereditary galactosemia, glucose malabsorption syndrome and galactose, or lactase deficiency.

With moderate renal failure, the drug should be taken with caution because of the risk of hypermagnesemia.

With a simultaneous deficiency of calcium and magnesium, magnesium deficiency should be replenished before taking calcium supplements or dietary supplements containing calcium.

When using pyridoxine at high doses (more than 200 mg / day) for a long time (for several months or in some cases - years) sensory axonal neuropathy can develop, which is accompanied by symptoms such as numbness and violation of proprioceptive sensitivity, tremor of the distal sections limbs and gradually developing sensory ataxia (impaired coordination of movements).
These disorders are usually reversible and pass after stopping the intake of vitamin B 6 .
Impact on the ability to drive vehicles and mechanisms

Does not affect.
There are no specific recommendations.


With normal kidney function, an overdose of magnesium when ingested usually does not lead to the occurrence of toxic reactions.
However, in the case of kidney failure, the development of magnesium poisoning is possible.
Symptoms of overdose, the severity of which depends on the concentration of magnesium in the blood: a decrease in blood pressure;
nausea, vomiting; depression of the central nervous system, decreased reflexes; changes on the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome.

Rehydration, forced diuresis.
With renal failure, hemodialysis or peritoneal dialysis is necessary.

Before prescribing other medicines, you should consult your doctor about the possibility of their simultaneous reception with the drug Magnelis B 6 forte, film-coated tablets.

Contraindicated combinations

With levodopa: the activity of levodopa is inhibited by pyridoxine (if this drug is not combined with the reception of inhibitors of peripheral decarboxylase of aromatic L-amino acids).
Any amount of pyridoxine should be avoided if levodopa is not taken in conjunction with inhibitors of the peripheral decarboxylase of aromatic L-amino acids.
Unrecommended combinations

Simultaneous use of drugs containing phosphates or calcium salts can impair magnesium absorption in the intestine.

Combinations that should be taken into account

When appointing the inside of tetracyclines, it is necessary to observe an interval of at least 3 hours between ingestion of tetracycline and Magnelis B 6 forte, tablets coated with a film coat,
Magnesium preparations reduce the absorption of tetracyclines.

The drug is approved for use as a means of OTC.


The drug should be stored out of reach of children at a temperature of no higher than 25 ° C.
Shelf life - 2 years.
Do not use after the expiry date printed on the package.

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