Universal reference book for medicines
Product name: MAGNEROT ® (MAGNEROT)

Active substance: magnesium orotate

Type: Magnesium-containing drug

Manufacturer: WOERWAG PHARMA (Germany) manufactured by MAUERMANN ARZNEIMITTEL (Germany)
Composition, form of production and packaging
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Tablets are white or almost white in color, round, flat, with chamfers on both sides and risk on one side.
1 tab.

magnesium orotate dihydrate 500 mg

Auxiliary substances: silicon dioxide colloid - 2.5 mg, carmellose sodium - 10 mg, cellulose microcrystalline - 67.5 mg, corn starch - 22.5 mg, povidone K30 - 30 mg, lactose monohydrate - 50 mg, sodium cyclamate - 1.5 mg, talc - 18.75 mg , magnesium stearate - 1.63 mg.

10 pieces.
- blisters (2) - packs of cardboard.
10 pieces.
- blisters (5) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2015.

PHARMACHOLOGIC EFFECT

The preparation of magnesium.
Magnesium is the most important macroelement. It is necessary to provide many energy processes, participates in the exchange of proteins, fats, carbohydrates and nucleic acids.
Magnesium takes part in the process of neuromuscular excitation, inhibiting neuromuscular transmission.
Of particular interest is magnesium as a natural physiological calcium antagonist. Magnesium controls the normal functioning of myocardial cells; participates in the regulation of contractile function of the myocardium. In stressful situations, an increased amount of free ionized magnesium is produced, which is why additional magnesium contributes to increased resistance to stress.
Magnesium deficiency leads to neuromuscular disorders (motor and sensory hyperexcitability, convulsions, paresthesia), psychological changes (depression, confusion and hallucinations), cardiovascular diseases (ventricular extrasystole, tachycardia, hypersensitivity to cardiac glycosides).
The deficiency of magnesium during pregnancy increases the likelihood of toxemia and premature birth.
The salts of orotic acid participate in the process of metabolism.
In addition, orotic acid salts are necessary for fixing magnesium on ATP in the cell and manifesting its action.
PHARMACOKINETICS

Approximately 35-40% of the dose is absorbed.
Hypomagnesemia stimulates the absorption of magnesium ions. The presence of salts of orotic acid, contribute to the improvement of magnesium absorption.
Magnesium is excreted by the kidneys, excretion decreases with magnesium deficiency and increases with its excess.

INDICATIONS

As part of complex therapy and for the prevention of the following diseases:

- myocardial infarction, angina pectoris;

- Chronic heart failure;

- arrhythmias caused by magnesium deficiency;

- spastic conditions - pain and muscle spasms (including angiospasm);

- Atherosclerosis;

- arteritis;

- violations of lipid metabolism.

DOSING MODE

Assign 2 tab.
3 times / day for 7 days, then - 1 tab. 2-3 times / day daily. The duration of the course of treatment is at least 4-6 weeks. If necessary, Magnnerot ® can be used for a long time.
At night cramps calf muscles recommend taking in the evening 2-3 tab.
preparation.
Tablets should be taken orally, before meals, with a small amount of liquid.

SIDE EFFECT

On the part of the digestive system: unstable stools and diarrhea (when taking the drug in high doses), which usually pass on their own with a lower dose.

Other: allergic reactions are possible.

CONTRAINDICATIONS

- urolithiasis disease;

- impaired renal function;

- predisposition to the formation of calcium-magnesium-ammonium-phosphate stones;

cirrhosis of the liver with ascites;

- children's age till 18 years;

- Hypersensitivity to the components of the drug.

The drug contains lactose, so do not prescribe it to patients with lactose intolerance, lactase deficiency or glucose-galactose malabsorption.

PREGNANCY AND LACTATION

It is possible to use Magnnerot during pregnancy and lactation (breastfeeding) according to the indications, because during these periods the need for magnesium significantly increases.
If its content is not balanced, then it can lead to serious complications, incl. miscarriage.
The use of the drug during pregnancy and during lactation is possible if the potential benefit to the mother exceeds the potential risk to the fetus and the baby.

APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindicated use in urolithiasis, impaired renal function.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Contraindicated in cirrhosis of the liver with ascites.

APPLICATION FOR CHILDREN

Contraindicated in children under the age of 18 years


SPECIAL INSTRUCTIONS

Magnnerot ® can be used for a long time.

It should be borne in mind that GI deficiency can lead to a deficiency of magnesium in the body;
consumption of food products with a reduced content of magnesium;exercise (due to increased sweating); chronic alcoholism (due to a decrease in the resorption of magnesium in the renal tubules and increased excretion of magnesium ions from the body); taking certain medications (cardiac glycosides, aminoglycoside antibiotics, oral contraceptives, diuretics, laxatives, glucocorticosteroids);conditions requiring increased intake of magnesium (hypodynamia, stress, pregnancy and lactation); prolonged exposure to the sun.
Impact on the ability to drive vehicles and manage mechanisms

The drug does not affect the ability to drive vehicles and other activities that require a high concentration of attention and speed of psychomotor reactions.

OVERDOSE

With normal kidney function, magnesium ingestion does not cause toxic reactions.
Magnesium poisoning can develop with kidney failure. Toxic effects mainly depend on the concentration of magnesium in the blood serum.
Symptoms: decreased blood pressure, nausea, vomiting, depression, delayed reflexes, respiratory depression, coma, cardiac arrest, anuric syndrome.

Treatment: rehydration, forced diuresis.
With renal failure, hemodialysis or peritoneal dialysis is necessary.
DRUG INTERACTION

With the simultaneous intake of magnesium-containing drugs with preparations of iron, sodium fluoride and tetracyclines, absorption of the latter may decrease.Therefore, you should take the medication with an interval of 2-3 hours.

Oral contraceptives, diuretics, muscle relaxants, GCS, insulin reduce the effect of the drug.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored at a temperature of no higher than 25 ° C, out of the reach of children.
Shelf life - 5 years.
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