Lornoksikam (lornoxicam)

LORNOKSIKAM (Lornoxicam).
     6-hydroxy Hlor-4- metil-N-2- piridil tieno H-2 [2,3-e] -1,2 - tiazin-3- karboksamid-1, 1-dioxide.
     Synonym : Ksefokam, Xefocam.
     Refers to a group oxycam.
     He has expressed anti - especially the blood activity (for action in postoperative pain and trauma are similar to morphine and tramadol significantly exceeded.) .
     When ingestion rapidly and completely absorbed, bioavailability reaches 100%, with C max intramuscular and oral application of 15 min and 2 hrs, T1 / 2 to 4 hours; Biotransformation exposed in the liver, displayed mainly bile.
     Assign with arthritis (RA, psoriaticheskom, chalky, infection), acute illness, koreshkovom syndrome, osteochondrosis, mialgii in postoperative pain and trauma.
     Applied inside or parenteral.
     Inside appointed to food with sufficient water. Start (1 day) dose of 0,016-0,032 grams (16-32 mg), followed by 0,008 g (8 mg) two times a day.
     For edema acute pain impose intramuscularly or intravenously dose of 0,008-0,016 grams (8-16 mg).
     Is the "normal" NPVS less damage to the mucous membrane of the digestive tract. Nevertheless, the application of the drug can be observed : erozivno- defeat ulcerated and bleeding in the digestive tract, neuralgia, a violation of the kidneys and liver, drowsiness, depression or arousal, increased blood pressure, peripheral oedema, sweating, radiation, thrombocytopenia, allergic skin reactions.
     Contraindications : gastric ulcer disease and gastrointestinal cancer, inflammatory bowel disease, bronchial asthma, a violation of liver and kidneys, long heart failure, arterial hypertension, radiation, thrombocytopenia, pregnancy, breast-feeding, age and 18 years and old age.
     Other NPVS and indirect anticoagulants increase the risk of side effects lornoksikama which, in turn, increases the hypoglycemic activity of derivatives sulfonylureas weakens diuretichesky effect and increases nefrotoksichnost diuretikov.
     We recommend caution when classes potentially hazardous activities that require special attention and reaction speed.
     Method of issuance : pills for 0,004 and 0,008 grams (4 and 8 mg N) (10, 20); Dried powder for injection solutions in vials of 0,008 g (8 mg) (N. 5).
     Storage : List B.

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