Universal reference book for medicines
Product name: TIZIDONE

Active substance: terizidone

Type: Anti-TB drug

Manufacturer: SIMPEX PHARMA (India)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

Antituberculous antibiotic.
Has a wide spectrum of antimicrobial action. It acts bacteriostatically.
It is active against Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium, as well as Staphylococcus aureus and Staphylococcus epidermidis.Enterococcus faecalis, Escherichia coli, Citrobacter spp., Enterobacter spp., Morganella morganii, Klebsiella pneumoniae and Pseudomonas aeruginosa are also sensitive.

Development of secondary resistance is rare.
Cross-resistance with other anti-tuberculosis drugs is not observed.
Absorption from the gastrointestinal tract - 70-90% (eating does not affect the rate of absorption).
Time to reach C max is 2-3 hours. Effective C min : 10-40 mg / L for Mycobacterium tuberculosis, 8-32 mg / L for staphylococci, and 20-250 mg / L for gram-negative bacteria .
It is well distributed in tissues and body fluids (lungs, bile, ascitic fluid, pleural effusion, synovial fluid, lymph, sputum).

Penetrates CSF (80-100% of the serum concentration), a higher concentration in CSF is created by inflammatory changes in the meninges.

Metabolized slightly.

Рў 1/2 - 21 hours. It is excreted by the kidneys (in unchanged form - 60-70%), intestines (insignificant quantity in unaltered form and in the form of metabolites).

Tuberculosis of various forms and localizations in the complex therapy of resistant forms of the disease.

Inside, regardless of food intake: adults and children over 14 years old and weighing less than 60 kg - 300 mg 2 times / day (600 mg / day);
with a body weight of 60-80 kg - 300 mg 3 times / day (900 mg / day). Adults with a body weight of more than 80 kg - 600 mg 2 times / day (1200 mg / day). Accept for 3-4 months.
With QC less than 30 ml / min dose and the frequency of intake is reduced.

From the side of the nervous system: headache, dizziness, increased excitability, tremor, insomnia, a feeling of intoxication;
in isolated cases - epileptiform cramps, depression, psychosis.
On the part of the digestive system: rarely - abdominal pain, flatulence, diarrhea.

Other: allergic reactions.

Organic diseases of the central nervous system (including cerebrosclerosis), epilepsy, mental disorders, alcoholism, pregnancy, lactation, children under 14 years of age, hypersensitivity to terizidone.

Contraindicated in pregnancy and lactation (breastfeeding).

Caution should be used for chronic kidney failure.

Contraindicated in children under 14 years.

With caution
should be used in elderly patients.
Caution should be used in patients with chronic heart failure, with chronic renal failure, in elderly patients.

Terizidone can cause deficiency of cyanocobalamin and / or folic acid, it is necessary to conduct appropriate examination and treatment.

It should be monitored monthly blood and urine indicators, liver function (ALT, ACT, bilirubin).

Patients should avoid the use of ethanol, t.
simultaneous administration with terizidone increases the incidence of side effects (up to the development of seizures).
In connection with the possibility of developing adverse reactions from the nervous system (depression, behavior change), it is necessary to monitor the patient's mental status.

Impact on the ability to drive vehicles and manage mechanisms

During the period of treatment, it is necessary to refrain from driving vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Ethanol increases the risk of epileptic seizures.

When used simultaneously with ethionamide, there is an increased risk of side effects from the CNS (especially seizures).

Simultaneous use with isoniazid increases the incidence of dizziness, drowsiness.

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