Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..
PHARMACHOLOGIC EFFECT
Vitamin A, refers to fat-soluble vitamins. Has a diverse impact on the vital functions of the body. It plays an important role in oxidation-reduction processes (due to a large number of unsaturated bonds), participates in the synthesis of mucopolysaccharides, proteins, lipids. Retinol plays an important role in maintaining the normal skin and epithelium of the mucous membranes, ensuring normal differentiation of the epithelial tissue, in the processes of photoreception (contributes to the adaptation of man to the dark). Retinol is involved in the mineral metabolism, the processes of cholesterol formation, enhances the production of lipase and trypsin, enhances myelopoiesis, cell division processes. Local action is mediated by the presence of specific retinol-binding receptors on the surface of the cells of the epithelium. It inhibits the processes of keratinization, enhances the proliferation of epithelial cells, rejuvenates cellular populations and reduces the number of cells that go along the path of terminal differentiation.
It is believed that retinol has an antitumor effect, which, however, does not extend to non-epithelial tumors.
INDICATIONS
Hypovitaminosis and avitaminosis A. Eye diseases (pigment retinitis, hemeralopia, xerophthalmia, keratomalacia, eczematous lesions of the eyelids), diseases and skin lesions (frostbites, burns, wounds, ichthyosis, hyperkeratosis, psoriasis, some forms of eczema and other inflammatory and degenerative pathological processes) . Complex therapy of rickets, hypotrophy, ARI, chronic bronchopulmonary diseases, erosive-ulcerative and inflammatory gastrointestinal lesions, liver cirrhosis. Epithelial tumors and leukemia (to increase the resistance of the hematopoietic tissue to the action of cytostatics in complex chemotherapy). Mastopathy (as part of a complex of non-hormonal drugs).
DOSING MODE
Apply inside, in / m, externally.
Therapeutic doses for avitaminosis of mild and moderate degree: adults - up to 33 000 IU / day, with hemeralopia, xerophthalmia, pigment retinitis - 50 000-100 000 IU / day. During pregnancy and during breastfeeding, the daily dose of retinol is 10,000 IU / day. Children - 1000-5000 IU / day depending on the age. With skin diseases adults - 50 000-100 000 IU / day, children - 5000-20 000 IU / day.
Oily solutions can also be applied externally - for burns, ulcers, frostbites, lubricating 5-6 times / day and covering with gauze; At the same time apply retinol inside or in / m.
SIDE EFFECT
Hypervitaminosis A: in adults - drowsiness, lethargy, headache, face hyperemia, nausea, vomiting, gait disorders, soreness in the bones of the lower limbs; children may have fever, drowsiness, sweating, vomiting, skin rashes.
Possible: increased cerebrospinal pressure (in infants, hydrocephalus may develop and protrusions of the fontanelle may develop).
CONTRAINDICATIONS
Gallstone disease, chronic pancreatitis (possibly exacerbation of the disease), I trimester of pregnancy.
PREGNANCY AND LACTATION
Contraindicated in the first trimester of pregnancy.
APPLICATION FOR FUNCTIONS OF THE LIVER
Use with caution in acute and chronic nephritis.
APPLICATION FOR CHILDREN
The application is possible according to the dosing regimen.
SPECIAL INSTRUCTIONS
With caution apply for acute and chronic nephritis, with cardiac decompensation.
DRUG INTERACTION
With simultaneous application with neomycin, a decrease in the absorption of retinol is possible.
