A typical clinical and pharmacological article
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..
PHARMACHOLOGIC EFFECT
Dermatoprotective agent. Stimulates skin regeneration, enhances the division of skin epithelial cells, inhibits keratinization, hinders the development of hyperkeratosis. Local action is due to the presence on the cell surface of the epithelium of specific retinol-binding receptors.
PHARMACOKINETICS
After application, it easily penetrates the skin. C max of active substances in the blood is reached 3-4 hours after application and is maintained for 12 hours. T 1/2 - 5.5 h.
INDICATIONS
Ichthyosis, hyperkeratosis, seborrheic dermatitis, psoriasis, pyoderma, atopic dermatitis, neurodermatitis, eczema, frostbite, burns, erosion, ulcers, cracks, skin atrophy after prolonged use of GCS.
DOSING MODE
Ointment should be applied to the affected areas of the skin with a thin layer 2 times / day (morning and evening). Duration of application - 4-12 weeks.
SIDE EFFECT
Local reactions: increased itching, hyperemia.
Possible: allergic reactions.
The appearance of these side effects requires the withdrawal of the drug.
CONTRAINDICATIONS
Hypervitaminosis A, I trimester of pregnancy, acute inflammatory skin diseases, hypersensitivity to the components of the drug.
PREGNANCY AND LACTATION
The drug is contraindicated in the first trimester of pregnancy.
In the period of lactation (breastfeeding) is not recommended to apply to the skin of the mammary glands.
DRUG INTERACTION
Do not use in combination with other drugs containing vitamin A and retinoids, to avoid hypervitaminosis A.
It is not compatible with tetracycline antibiotics.
