Universal reference book for medicines
Name of the drug: XYDIFON (XYDIFON)

Active substance: etidronic acid

Type: A drug regulating the exchange of calcium and phosphorus

N.Рђ. Semashko OJSC (Russia)
Composition, form of production and packaging
A solution of 20% for preparation of 2% solution for oral administration is
colorless, odorless.

100 ml

etidronic acid (potassium hydroxyethylidene diphosphonate dihydrate) 20 g

Excipients: sodium hydroxide, purified water.

50 ml - bottles.

100 ml - bottles.

100 ml - polyethylene containers.

250 ml - polyethylene containers.


Description of the drug approved by the manufacturer for the printed edition of 2012.


A drug that regulates calcium metabolism.
Prevents excessive calcium output from the bones, thereby preventing osteoporosis, prevents pathological calcification of soft tissues.
The drug prevents crystal formation, as well as the growth and aggregation of crystals of calcium salts in the urine.
Keeping the calcium ions in a dissolved state, Xidiphone prevents the recurrence of stones, eliminating the possibility of formation of insoluble calcium salts (with oxalates, mucopolysaccharides, phosphates, etc.), has a moderate anti-inflammatory effect in interstitial nephritis.
Xidiphon, like other complexing compounds, has the property of accelerating the excretion of heavy metals - lead, tin, antimony, strontium, magnesium, silicon.
Does not disturb the balance of microelements.
Also confirmed the effectiveness of the use of Xidifon in the complex therapy of bronchial asthma.
In this case, the mechanism of the action of Xidiphon is not fully understood. It is assumed that it changes the biophysical state of the membranes of immunocompetent cells, stabilizing them.


Absorbed from the stomach during the first 30 minutes after ingestion.

Metabolism and excretion

T 1/2 is 24 hours, in the body it is not metabolized and is excreted unchanged in the main with urine.


As a means of regulating calcium metabolism in adults and children:

- with urolithiasis and other kidney diseases;

- with hyperavitaminosis D;

- with hyperparathyroidism and concomitant interstitial nephritis;

- for the treatment and prevention of osteoporosis;

- as a means of preventing the development of osteopenia and osteoporosis with prolonged immobilization of patients with rheumatoid arthritis, which increases bone mass in secondary osteoporosis.

To accelerate the removal from the body of excess heavy metals lead, tin, strontium, silicon and antimony.

In the complex therapy of bronchial asthma of the lung and moderate course in adults with the goal of stabilizing the membranes of immunocompetent cells.

In the complex therapy of hormone-dependent bronchial asthma in adults with the goal of preventing osteoporosis.


Xidiphon is taken orally 30 minutes before meals, in the form of a solution diluted to 2%, which is prepared by adding 9 parts of distilled or boiled water to 1 part of the base 20% solution (eg, to 50 ml of 20% solution 450 ml of water are added), the diluted solution is stored in a refrigerator.

Adults and children over 10 years of age are prescribed 300 mg (1 tablespoon) 2-3 times / day.

Children from 3 to 10 years -
on 200 mg (1 dessert spoon) 2-3 times / day.
Children under 3 years -
at the rate of 10 mg / kg body weight (by 1 teaspoon) 2-3 times / day.
The primary course of treatment is 14 days.
For crystalline and the presence of concrements in the kidneys spend 5-6 courses with three-week breaks for 1-2 years. Toprevent the recurrence of stone formation, the drug is prescribed up to 2-6 months.
For the treatment and prevention of osteoporosis, Xidiphon is used at a dose of 5-7 mg / kg for 2-3 months, after 1-2 months, the course of treatment is repeated.

In trabecular osteoporosis and osteopenia in patients with rheumatoid arthritis, Xidiphon is used for at least a year at a rate of 5-10 mg / kg body weight in 2 divided doses.
At the same time, it is recommended to eat foods rich in calcium salts (equivalent to 500 ml of milk), or, if for some reason, it is impossible, to take calcium gluconate 1.5 g / day.
When chronic intoxication with heavy metals and when living in adverse environmental conditions for heavy metals , the use of Xidiphon in a dose of 10 mg / kg of body weight for 7-10 days of each month is recommended.

In bronchial asthma, Xidiphon is used in complex therapy in adults over 16 years for no more than 30 days.


On the part of the digestive system: in some cases, there is a laxative effect, with the daily dose to be divided into a larger number of receptions.

From the side of metabolism: with prolonged administration of the drug Xidiphon in high doses - hypomagnesemia and rickhitoid effect, for the prevention of the recommended use of magnesium-containing drugs in minimal doses and the periodic administration of vitamin D in therapeutic doses.

Other: it is possible to change the lipid peroxidation, which is eliminated by taking 3-5 drops of a 5% vitamin E oil solution 1 time / day.


- hypocalcemia;

- Pregnancy;

- the period of lactation (breastfeeding);

- Hypersensitivity to the drug.


The drug is contraindicated for use in pregnancy and lactation.

It is not established whether etidronic acid is excreted in breast milk.


When used in patients with reduced renal function, the dosage regimen should be adjusted.


It is possible to use the drug according to the indications in doses taking into account the age of the patient.


With caution apply the drug in patients with chronic enterocolitis.

When used in patients with reduced renal function, the dosage regimen should be adjusted.

Patients taking Xidiphon should receive a sufficient amount of calcium and vitamin D.


It is possible to strengthen the above described side effects.


The drug interaction of the drug Xidiphone is not described.


The drug is released by prescription.


The drug should be stored out of reach of children, protected from light at a temperature of at least 0 В° C.
Shelf life - 3 years.
A diluted 2% solution is stored in the refrigerator for 1 month.

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