Composition, form of production and packaging
? Cream for external application of white color, homogeneous.
1 g
clotrimazole 10 mg
Auxiliary substances: propylene glycol 50 mg, white petrolatum 120 mg, paraffin liquid 60 mg, wax emulsion cetomacrogol 135 mg, benzyl alcohol 10 mg, methyl parahydroxybenzoate 1.5 mg, propyl parahydroxybenzoate 0.5 mg, butyl hydroxytoluene 1 mg, sodium dihydrogen phosphate dihydrate - 0.8 mg, sodium hydrophosphate - 0.6 mg, purified water - 1000 mg.
20 g - aluminum tubes (1) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2016.
PHARMACHOLOGIC EFFECT
Antifungal preparation of a wide spectrum of action for external application. The imidazole derivative. Disrupts the synthesis of ergosterol, which is part of the cell membrane of fungi, which leads to lysis of the cell.
It is active against dermatophytes (Trichophyton, Epidermophyton, Microsporum), yeast and yeast-like fungi (Candida, Torulopsis, Rhodoturola), mold fungi, as well as Malassezia furfur, Aspergillus; some strains of gram-positive bacteria (Streptococcus spp., Staphylococcus spp., Corynebacterium minutissimum), gram-negative bacteria (Bacteroides spp., Gardnerella vaginalis), and Trichomonas vaginalis.
PHARMACOKINETICS
With external application, clotrimazole penetrates well into various layers of the skin, reaching therapeutic concentrations.
INDICATIONS
- dermatophytosis of the head (including face), body, legs;
- mycosis of the nails;
- colored lichen;
- Candidiasis of the skin;
- Candid paronychia;
Candidiasis vulvitis;
Candidiasis balanitis;
- Candidiasis of external genitalia and anorectal area;
- fungal diaper dermatitis;
- Erythrazm.
DOSING MODE
The necessary amount of cream is applied to the previously washed and dry affected area of ​​the skin 2-3 times / day. Treatment should continue for 2-4 weeks after the disappearance of clinical symptoms to ensure mycological cure and prevent relapse.
SIDE EFFECT
Rarely: local irritation, which disappears on its own while continuing therapy.
CONTRAINDICATIONS
- Hypersensitivity to clotrimazole.
PREGNANCY AND LACTATION
The safety of Candida during pregnancy and lactation is not established. Therefore, the administration of the drug in high doses (in large areas of the skin) or for a long time in these periods should be avoided.
SPECIAL INSTRUCTIONS
It is necessary to avoid the use of the drug in areas of the skin with violations of the integrity of the skin.
OVERDOSE
At present, no cases of an overdose of Candide have been reported.
DRUG INTERACTION
With simultaneous application with nystatin, Candida activity may decrease.
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored in a dry, dark place.
