Composition, form of production and packaging
? Capsules size 3, with a gray body and a lid of a dark green color; the contents of the capsules are white or white powder with a yellowish hue.
1 caps.
loperamide hydrochloride 2 mg
Excipients: magnesium stearate, corn starch, microcrystalline cellulose.
10 pieces. - packings of cellular contour (1) - packs cardboard.
10 pieces. - packings cellular planimetric (2) - packs cardboard.
10 pieces. - packings cellular planimetric (3) - packs cardboard.
? Tablets chewing white or white with a yellowish hue of color, flat-cylindrical shape, with a risk, with the smell of anise; slight marmorage is allowed.
1 tab.
loperamide hydrochloride 2 mg
Auxiliary substances: polymethylsiloxane, potato starch, lactose, sucrose, microcrystalline cellulose, silicon dioxide colloid (aerosil), aspartame, povidone (Kollidon 90), xylitab 300, lactitol, kollidone SR, menthol, magnesium stearate, anise oil.
4 things. - packings of cellular contour (1) - packs cardboard.
4 things. - packings cellular planimetric (2) - packs cardboard.
4 things. - packings cellular planimetric (3) - packs cardboard.
6 pcs. - packings of cellular contour (1) - packs cardboard.
6 pcs. - packings cellular planimetric (2) - packs cardboard.
6 pcs. - packings cellular planimetric (3) - packs cardboard.
7 pcs. - packings of cellular contour (1) - packs cardboard.
7 pcs. - packings cellular planimetric (2) - packs cardboard.
7 pcs. - packings cellular planimetric (3) - packs cardboard.
10 pieces. - packings of cellular contour (1) - packs cardboard.
10 pieces. - packings cellular planimetric (2) - packs cardboard.
10 pieces. - packings cellular planimetric (3) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2016.
PHARMACHOLOGIC EFFECT
Antidiarrhoeal drug. Loperamide, by binding to opioid receptors of the intestinal wall (modulation of cholinergic and adrenergic neurons via guanine nucleotides), reduces the tone and motility of smooth intestinal muscles (by inhibiting the release of acetylcholine and prostaglandins). Slows down the peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, promotes retention of fecal masses and reduced urge to defecate.
The action comes quickly and lasts for 4-6 hours.
PHARMACOKINETICS
Loperamide hydrochloride is almost completely metabolized by the liver by conjugation. T 1/2 is 9-14 hours. It is excreted mainly with bile and urine in the form of conjugated metabolites.
INDICATIONS
Symptomatic treatment of acute and chronic diarrhea:
- Allergic, emotional, medicinal, radiation genesis;
- with a change in diet and quality of food, in violation of metabolism and absorption;
- as an aid for diarrhea of ​​infectious genesis.
Regulation of stool in patients with ileostomy.
DOSING MODE
The drug should be taken orally, washed down with water.
Adults with acute and chronic diarrhea are prescribed in an initial dose of 4 mg (2 tablets or 2 capsules), then 2 mg (1 tablet or 1 capsule) after each act of defecation in the case of a loose stool. The maximum daily dose is 16 mg (8 tablets or 8 caps.).
Children over the age of 6 years are prescribed 2 mg (1 tablet or 1 capsule) after each act of defecation in the case of a loose stool. The maximum daily dose is 6 mg (3 tablets or 3 capsules).
If the chair is normalized or there is no stool for more than 12 hours, treatment with DiarРѕ should be stopped.
SIDE EFFECT
On the part of the digestive system: gastralgia, dry mouth, intestinal colic, nausea, vomiting, constipation; very rarely - intestinal obstruction.
From the side of the central nervous system: drowsiness, dizziness.
Allergic reactions: skin rash.
CONTRAINDICATIONS
- diverticulosis;
- intestinal obstruction;
- ulcerative colitis in the phase of exacerbation;
- diarrhea against a background of acute pseudomembranous enterocolitis;
- monotherapy of dysentery and other gastrointestinal infections;
- I trimester of pregnancy;
- lactation period;
- children's age till 6 years;
- Hypersensitivity to the components of the drug.
With caution , use the drug for liver failure.
PREGNANCY AND LACTATION
Contraindicated use of the drug in the first trimester of pregnancy and during breastfeeding.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
With caution, use the drug for liver failure.
APPLICATION FOR CHILDREN
Contraindication: children under 6 years.
Children over the age of 6 years with acute diarrhea are prescribed in an initial dose of 2 mg (1 tab.), Then - 2 mg (1 tab.) After each act of defecation in the case of a loose stool. The maximum daily dose is 6 mg (3 tablets).
SPECIAL INSTRUCTIONS
If there is no effect for 48 hours, the drug should be discontinued and consult a doctor.
OVERDOSE
Symptoms: depression of the central nervous system (stupor, impaired coordination of movements, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.
Treatment: antidote - naloxone. Given that the duration of action of loperamide is greater than that of naloxone, it is possible to re-administer the latter.
Symptomatic treatment: activated charcoal, gastric lavage, IVL. Medical observation is necessary for at least 48 hours.
DRUG INTERACTION
Data on the drug interaction of the DiaRВ® preparation are not provided.
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of reach of children, dry, protected from light at a temperature of no higher than 25 В° C. Shelf life - 3 years.
