A typical clinical and pharmacological article
This information is a reference and it is not enough that the drug was prescribed by a doctor. .
PHARMACHOLOGIC EFFECT
Combined antimicrobial preparation. The effectiveness of the drug is due to the presence in its composition of active ingredients such as metronidazole and chlorhexidine.
Metronidazole is a derivative of nitroimidazole with antiprotozoal and antibacterial action against anaerobic protozoa and anaerobic bacteria that cause periodontitis: Porphyromonas gingivalis, Prevotella intermedia, Prevotella denticola, Fusobacterium fusiformis, Wolinella recta, Treponema spp., Eikenella corrodens, Borrelia vincenti, Bacteroides melaninogenicus, Selenomonas spp .
Inactive against aerobic bacteria.
The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole reacts with the DNA of a cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Chlorhexidine - a disinfectant, is active against a wide range of vegetative forms of gram-negative and gram-positive microorganisms, yeast, dermatophytes and lipophilic viruses. On bacterial spores acts only at elevated temperature. The bactericidal effect is due to the binding of cations (the result of the dissociation of chlorhexidine salt in a physiological environment) with negatively charged walls of bacterial cells and extramicrobial complexes. At low concentrations, disrupting the osmotic equilibrium of bacterial cells and the release of potassium and phosphorus ions from them, has a bacteriostatic effect; at high concentrations, the cytoplasmic content of the bacterial cell is deposited, leading ultimately to the death of the bacteria.
INDICATIONS
- acute gingivitis;
- Acute necrotic ulcerative gingivitis of Vincent;
- chronic edematous gingivitis;
- chronic hyperplastic gingivitis;
- chronic atrophic (desquamative) gingivitis;
- chronic periodontitis;
- Periodontal abscess;
- recurrent aphthous (ulcerative) stomatitis;
- gangrenous pulpitis;
- postextraction alveolitis;
- youthful periodontitis;
- toothache of infectious origin.
DOSING MODE
The drug is intended for dental use only!
Locally, after a thorough brushing of teeth, rinse the mouth with a soda solution and rub the gums with a dry cotton ball. Squeeze a small amount of gel onto the toothbrush and apply the gel with a toothbrush on the gums and interdental spaces. After applying the gel for 30 minutes, do not rinse your mouth and eat. Apply on the gum area 2 times / day. The duration of treatment is an average of 7-10 days.
To prevent the disease, a small amount of gel (the size of a pea) is added to the toothpaste. Preventative courses of treatment are conducted for 2-4 weeks 1-2 times a year.
SIDE EFFECT
"Metallic" taste in the mouth, headache, allergic reactions (skin rash, itching, urticaria).
CONTRAINDICATIONS
- hypersensitivity (including to metronidazole, chlorhexidine and a derivative of nitroimidazole).
With caution : pregnancy, lactation.
PREGNANCY AND LACTATION
The use of the drug in pregnant and lactating women is undesirable.
SPECIAL INSTRUCTIONS
Avoid contact with eyes.
The use of the drug in pregnant and lactating women is undesirable.
DRUG INTERACTION
Strengthens the anticoagulant effect of warfarin (increasing the time of prothrombin formation).
Simultaneous use with disulfiram increases toxicity, which can lead to the development of neurological symptoms.
The antimicrobial activity of metronidazole decreases with simultaneous use with phenobarbital and phenytoin because of the accelerated metabolism of metronidazole.
Cimetidine suppresses the metabolism of metronidazole, which can lead to an increase in the concentration of metronidazole in the blood serum.
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
Store in a place inaccessible to children, at a temperature not exceeding 25 В° C. Do not freeze.
