Composition, form of production and packaging
? Suppositories rectal from white to white with a yellowish hue of color, torpedo-shaped, without visible inclusions on the longitudinal section.
1 supp.
aminodihydrophthalazinedione sodium 50 mg
- "- 100 mg
Excipients: Witepsol W-35 (glycerides of fatty acids) - 575 mg, Witepsol H-15 (glycerides of fatty acids) - 575 mg.
5 pieces. - packings of cellular contour (1) - packs cardboard.
5 pieces. - packings cellular planimetric (2) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2017.
PHARMACHOLOGIC EFFECT
The mechanism of action is related to the ability to influence the functional metabolic activity of macrophages.
In inflammatory diseases, reversible (for 6-8 hours) inhibits excessive synthesis of tumor necrosis factor, interleukin-1 and other pro-inflammatory cytokines, active forms of oxygen by hyperactivated macrophages, determining the degree of inflammatory reactions, their cyclicity, and the severity of intoxication. Normalization of the functional state of macrophages leads to the restoration of the antigen presenting and regulating function of macrophages, to a decrease in the level of autoaggression.
Stimulates bactericidal activity of neutrophilic granulocytes, enhancing phagocytosis and increasing unspecific resistance of the organism to infectious diseases.
PHARMACOKINETICS
It is excreted from the body, mainly by the kidneys. After rectal administration, T 1/2 is 40-60 minutes.
The main pharmacological effects are observed for 72 hours.
INDICATIONS
Suppositories rectal 100 mg
As an immunomodulatory and anti-inflammatory agent in the complex therapy of immunodeficient conditions in adults and adolescents over 12 years of age:
- infectious intestinal diseases, accompanied by intoxication and / or diarrhea;
- Stomach ulcer and duodenal ulcer;
- viral hepatitis;
- chronic recurrent diseases caused by the herpes virus;
- diseases caused by the human papillomavirus;
- infectious and inflammatory diseases of the urogenital tract (urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis, acute and chronic salpingoophoritis, endometritis);
- Pyoinflammatory diseases of the pelvic organs;
- postoperative rehabilitation of patients with uterine myoma;
- Complications of the postoperative period in women of reproductive age;
- postoperative purulent-septic complications and their prevention (including in cancer patients);
- chronic recurrent furunculosis, erysipelas;
- asthenic conditions, neurotic and somatoform disorders, decrease in physical working capacity (including athletes);
- mental, behavioral and post-abstinence disorders in alcohol and drug dependence;
- inflammatory diseases of the mucous membrane of the oral cavity and throat, periodontal disease;
- Nonspecific prevention and treatment of influenza and acute respiratory infections.
Suppositories rectal 50 mg
As an immunomodulatory and anti-inflammatory drug in complex therapy in children aged 6-12 years:
- infectious intestinal diseases, accompanied by intoxication and / or diarrhea;
- Stomach ulcer and duodenal ulcer;
- viral hepatitis;
- chronic recurrent diseases caused by the herpes virus;
- diseases caused by the human papillomavirus;
- Purulent surgical diseases (including burn injuries, recurrent furunculosis, chronic osteomyelitis, gangrenous appendicitis with omentitis, peritonitis, purulent pleurisy);
- asthenic conditions, neurotic and somatoform disorders, decreased physical performance;
- postoperative purulent-septic complications and their prevention (including in cancer patients);
- treatment and prevention of urogenital infections of bacterial and viral etiology;
- inflammatory diseases of the mucous membrane of the oral cavity and throat, periodontal disease;
- frequent recurrent diseases of the respiratory tract and ENT organs of bacterial and viral etiology (frequent acute respiratory infections, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis);
- prevention of influenza and acute respiratory infections.
DOSING MODE
Rectally. The suppository is released from the contoured package and then injected into the rectum. It is recommended to release the intestine beforehand.
The dose and duration of the drug depends on the nature, severity and duration of the disease.
Suppositories 100 mg
Adults and teenagers over 12 years of age
In acute intestinal infections accompanied by diarrheal syndrome, the initial dose is 2 soups. once, then - 1 soup. 2 times / day until relief of symptoms of intoxication.Perhaps the subsequent continuation of the course for 1 soup. with an interval of 72 hours. The rate is 20-25 soups.
With peptic ulcer of the stomach and duodenum in the acute period - 2 soups. 1 time / day for 2 days, then - 1 soup. with an interval of 72 hours. The course is 15-25 soups. In the chronic period - within 5 days of 1 supp. 1 time / day, then - 1 soup. after 72 hours. The course is 20 soups.
With viral hepatitis, the initial dose is 2 supp. once, then 1 soup. 2 times / day until the relief of symptoms of intoxication and inflammation. The subsequent continuation of the course - 1 soup. with an interval of 72 hours. The rate is 20-25 soups.
In chronic recurrent diseases caused by the herpes virus, 1 supp is prescribed. daily for 5 days, then for 1 soup. every other day for 15 days.
In diseases caused by the human papillomavirus, the drug is prescribed for 5 days for 1 supp. 1 time / day, then - 1 soup. in one day. The course is 20 soups.
With urogenital infections (chlamydial and trichomonadal urethritis, chlamydial prostatitis) - on the 1st day of 1 supp. 2 times / day, then - 1 soup. in one day. The rate is 10-15 soups. depending on the severity of the pathological process.
With salpingo-oophoritis, endometritis in an acute period is prescribed for 2 days for 2 soups. 1 time / day, then - 1 soup. with an interval of 72 hours. In the chronic period - within 5 days of 1 supp. 1 time / day, then - 1 soup. every 72 hours. The course is 20 soups.
In acute and chronic purulent diseases of the pelvic organs - in the acute period, the drug is prescribed on the 1st day of 2 supp. once, then within 3 days for 1 supp.daily, then - 1 soup. every other day for 5 days. The course is 10 soup. In the chronic period, the drug is prescribed for 5 days for 1 supp. 1 time / day, then - 1 soup.every 72 hours. The course is 20 soups.
For postoperative rehabilitation of patients with uterine myoma and with complications of the postoperative period in patients of reproductive age - within 5 days of 1 supp. 1 time / day, then - 1 soup. in one day. Course - 15 soups.
For the prevention and treatment of surgical complications in the pre- and postoperative period (including cancer patients) prescribe before surgery - within 5 days of 1 supp. 1 time / day, after operation - 1 supp. in a day (5 soup.) and 5 soups. with an interval of 72 hours. In severe cases, the initial dose of the drug is 2 soups. once or 1 soup. 2 times / day. Course - 20 soups.
With chronic recurrent furunculosis, erysipelas - within 5 days of 1 supp. 1 time / day, then - 1 soup. in one day. Course - 20 soups.
With asthenic conditions, neurotic and somatoform disorders, with mental, behavioral and post-abstinence disorders, in patients with alcohol and drug dependence - within 5 days of 1 supp. daily, then - 1 soup. after 72 hours. Course - 15-20 supp.
To increase physical performance - 1 soup. every other day - 5 soup., then - 1 soup. after 72 hours. Course - up to 20 soups.
With inflammatory diseases of the mucous membrane of the oral cavity and throat, periodontal diseases, the initial dose of the drug is 1 soup. daily for 5 days, then for 1 soup. with an interval of 72 hours. Course - 15 soups.
For non-specific prevention and treatment of influenza and acute respiratory infections - 1 soup. 1 time / day. Course - 5 days.
Suppositories 50 mg
Children aged 6-12 years
In acute infectious intestinal diseases, accompanied by diarrhea syndrome , the initial dose is 2 supp. once, then 1 soup. 2 times / day until relief of symptoms of intoxication. Perhaps the subsequent continuation of the course for 1 soup. with an interval of 72 hours. Course - 20 soups.
With peptic ulcer of the stomach and duodenum in the acute period - in the first 2 days of 2 supp. 1 time / day, then 1 soup. with an interval of 72 hours. Course - 15-25 soups. In the chronic period - within 5 days of 1 supp. 1 time / day, then 1 soup. after 72 hours. Course - 20 soups.
With viral hepatitis, the initial dose is 2 supp. once, then 1 soup. 2 times / day until the relief of symptoms of intoxication and inflammation. The subsequent continuation of the course - 1 soup. with an interval of 72 hours. Course - 20 soups.
In chronic recurrent diseases caused by the herpes virus, 1 supp is prescribed. daily for 5 days, then 1 soup. In a day - 15 soups.
In diseases caused by the human papillomavirus virus , 1 supp is prescribed for 5 days. 1 time / day, then 1 soup. in one day. Course - 20 soups.
When purulent surgical diseases (burn lesions, recurrent furunculuse, chronic osteomyelitis, gangrenous appendicitis with omentitis, purulent pleurisy), appoint 1 supp. daily for 5 days, then 1 soup. every other day for 10 days.
At asthenic conditions, neurotic and somatoform disorders - within 5 days of 1 supp. daily, then 1 soup. after 72 hours. Course - 15 soups.
To increase physical performance - 1 soup. in one day; course - 5 soups.
For the prevention and treatment of surgical complications in the pre- and postoperative period (including cancer patients), 5 days prior to surgery, one dose is prescribed. 1 time / day, 1 soup. the day after the operation (5 supp.) and 5 soups. - with an interval of 72 hours. In severe cases, the initial dose is 2 soups. once or 1 soup. 2 times / day. Course - 20 soups.
For treatment and prophylaxis of urogenital infections of bacterial and viral etiology, the drug is prescribed on the 1st day of 1 supp. 2 times / day, then 1 soup. in one day. The course is 10-15 soups. (depending on the severity of the pathological process).
With inflammatory diseases of the mucous membrane of the oral cavity and throat, periodontal diseases, the initial dose is 1 soup. daily - 5 soups, then 1 soup. with an interval of 72 hours. Course - 15 soups.
With frequent recurrent diseases of the respiratory tract and ENT organs of bacterial and viral etiology (frequent acute respiratory infections, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis) - 1 supp. daily for 5 days, then 1 soup. every other day for 10 days. Course - 15 soups.
For the prevention of influenza and acute respiratory infections - 1 soup. 1 time / day. The course is 5 soup.
SIDE EFFECT
Rarely: allergic reactions are possible.
CONTRAINDICATIONS
- Pregnancy;
- lactation period;
- Children under 6 years (for suppositories 50 mg);
- Individual intolerance.
PREGNANCY AND LACTATION
The drug is contraindicated in pregnancy and lactation.
APPLICATION FOR CHILDREN
Contraindicated in childhood to 6 years (for suppositories 50 mg).
SPECIAL INSTRUCTIONS
With the simultaneous use of the drug Galavit В® with antibiotics, it is possible to reduce the exchange rates of the latter.
OVERDOSE
Data on overdose are absent.
DRUG INTERACTION
Cases of incompatibility of the drug Galavit В® with other drugs have not been noted.
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of reach of children, dry, protected from light at a temperature of no higher than 25 В° C. Shelf life - 3 years.
