Universal reference book for medicines

Active substance: nonappropriate

Type: Vaccine for the prevention of rabies

Producer: The company for the production of bacterial and viral preparations of the Institute of Poliomyelitis and Viral Encephalitis.M.P.Chumakova RAMS FSUE (Russia)
Lyophilizate for the preparation of a solution for the / m introduction in the form of a porous mass of white, hygroscopic.
1 dose (1 ml)

vaccine for the prevention of rabies (specific antigen of rabies virus, strain "Vnukovo-32") 2.5 ME

Excipients: human albumin 5 mg, sucrose 75 mg, gelatin 10 mg.

Solvent: water d / and.

2.5 IU (1 dose) - ampoules (5) in a kit with a solvent of 1 ml amp.
(5) - packs of cardboard.

Description of the drug approved by the manufacturer for the printed edition of 2014.


The vaccine induces the development of immunity against rabies.


Treatment-prophylactic and preventive immunization of a person against rabies.

Treatment and prophylactic immunization

- contact and bites of people with rabies in animals, animals with suspected rabies, wild or unknown animals.

Preventive immunization

- persons with a high risk of rabies (laboratory staff working with street rabies virus, veterinarians, gamekeepers, hunters, foresters, persons engaged in catching and keeping animals and other professional groups).


The contents of the ampoule with the vaccine should be dissolved in 1.0 ml of water for injection.
The dissolution time should not exceed 5 minutes. Dissolved vaccine is a clear or slightly opalescent liquid from colorless to light yellow color.
Dissolved vaccine is injected slowly intramuscularly into the deltoid muscle of the shoulder, children under 5 years of age - in the upper part of the anterolateral surface of the thigh.

The introduction of the vaccine into the gluteal region is not allowed.

The drug is not suitable for use in ampoules with broken integrity, marking, as well as when the color and transparency change, if the expiration date, improper storage.

Opening of ampoules and the vaccination procedure are carried out with strict compliance with aseptic rules.

Storage of dissolved vaccine for more than 5 minutes is not allowed.

Vaccinated should be under medical supervision for at least 30 minutes.

Places for vaccination should be equipped with anti-shock therapy.

Rendering anti-rabic help

Anti-rabies care consists of the local treatment of wounds, scratches, abrasions, places of mismanagement and subsequent administration of an antirabic vaccine, or, in the presence of indications, combined administration of anti-rabies immunoglobulin (AIG) and rabies vaccine.
The interval between the introduction of AIG and an anti-rabies vaccine is no more than 30 minutes.
Local wound treatment

Local treatment of wounds (bites, scratches, abrasions) and places of muffle should begin immediately or as soon as possible after bite or damage.
It consists in abundant rinsing for a few minutes (up to 15 minutes) of the wound surface with water with soap or other detergent (detergent) or in the absence of soap or detergent, the place of damage is washed with a jet of water. After this, the edges of the wound should be treated with 70% alcohol or 5% aqueous-alcoholic iodine solution.
If possible, sutures should be avoided.
Sealing is shown only in the following cases:
- with extensive wounds - several leading skin seams after pre-treatment of the wound;

- for cosmetic indications (application of skin seams to facial wounds);

- stitching of bleeding vessels in order to stop external bleeding.

In the presence of indications for the use of an antirabic immunoglobulin, it is used immediately before the application of the sutures (see the section Dose of an antirabic immunoglobulin (AIG)).

After the local treatment of injuries (injuries) immediately begin treatment and preventive immunization.

Treatment and prophylactic immunization

Contact and bites of people with rabies sick animals, animals with suspected rabies, wild or unknown animals.
None. Pregnancy is not a contraindication.
A detailed scheme of treatment and prophylactic immunization and notes to the scheme is presented in the table (Scheme of curative prophylactic vaccinations with rabies vaccine and rabies immunoglobulin (AIG).

Treatment of all people exposed to the risk of infection with rabies is subject to treatment and prophylaxis.
If there are indications for combined treatment, first AIG is administered and, no more than 30 minutes after it, an anti-rabies vaccine is administered.
Anti-rabies immunoglobulin (AIG) is prescribed as soon as possible after contact with a rabid animal or animal with suspected rabies, wild or unknown animals.

Before the introduction of a heterologous (horse) rabies immunoglobulin, it is necessary to check the individual sensitivity of the patient to the horse protein (see "Instructions for the use of rabies anti-rabies immunoglobulin from horse serum, liquid").
Before the introduction of a homologous (human) rabies immunoglobulin, individual sensitivity is not checked.
A heterologous antirabic immunoglobulin is administered no later than 3 days after the bite, homologous anti-rabies immunoglobulin is administered no later than 7 days after the bite.

The dose of anti-rabies immunoglobulin (AIG).
Heterologous (horse) rabies immunoglobulin is prescribed in a dose of 40 ME per 1 kg of body weight. Homologous (human) rabies immunoglobulin is prescribed in a dose of 20 ME per 1 kg of body weight. The volume of heterologous anti-rabies immunoglobulin administered should not exceed 20 ml.
Introduction of an antirabic immunoglobulin (AIG).
As much of the recommended dose of AIG can be infiltrated into the tissue around the wound and deep inside the wound. An unused portion of the dose of the drug is injected intramuscularly into the site different from that of the rabies vaccine.
Preventive immunization

For prophylactic purposes, people who have a high risk of getting rabies are immunized (laboratory staff working with street rabies virus, veterinarians, gamekeepers, hunters, foresters, persons engaged in catching and keeping animals and other professional groups).
The vaccine is injected intramuscularly into the deltoid muscle of the shoulder by 1.0 ml at 0, 7 and 30 days.
Revaccination is carried out once, at a dose of 1.0 ml every other year and every three years thereafter.
The scheme of preventive immunization

Primary immunization Three injections in 0.7 and 30 days of 1.0 ml

First revaccination after 1 year One injection, 1.0 ml

Subsequent revaccinations every 3 years One injection, 1.0 ml

Preventive immunization of contingents of increased risk of infection with rabies is carried out in vaccination rooms of medical and preventive institutions, where they fill out and issue a "Certificate of preventive vaccinations", where they make all the necessary information (names, series, doses, multiplicities and dates of receipt of drugs).


1. The introduction of a vaccine may be accompanied by a local or general reaction.
Local reaction is characterized by a slight swelling, redness, itching, pain at the injection site, an increase in regional lymph nodes. The general reaction can be manifested in the form of malaise, headache, weakness, fever. Symptomatic therapy, the use of hyposensitizing drugs and antihistamines are recommended.
In rare cases, neurological symptoms may develop, such a patient should be juicy hospitalized.

2. After the introduction of rabies immunoglobulin from the blood serum of the horse, complications may occur: a local allergic reaction, occurring 1-2 days after administration;
Serum sickness, which occurs most often on day 6-8; anaphylactic shock. In the case of an anaphylactoid reaction, a solution of epinephrine or norepinephrine in an age dosage and 0.2-1.0 ml of ephedrine 5% is injected subcutaneously.
When symptoms of serum sickness appear, parenteral administration of antihistamines, corticosteroids, and calcium preparations is recommended.


Treatment and prophylactic immunization

- none.

Preventive immunization

- acute infectious and non-infectious diseases, chronic diseases in the stage of exacerbation or decompensation - vaccinations are carried out not earlier than one month after recovery (remission);

- Systemic allergic reactions to the previous administration of anti-rabies immunoglobulin (generalized rash, Quincke's edema, etc.);

- allergic reactions to antibiotics;

- Pregnancy.


Pregnancy is not a contraindication only for treatment and preventive immunization.


During the course of treatment and preventive vaccination, vaccination with other drugs is prohibited.
After the vaccination against rabies vaccination with other vaccines is allowed no earlier than 2 months.
Preventive vaccination is given no earlier than 1 month after vaccination against another infectious disease.


For treatment and prevention institutions.


The vaccine is stored and transported at a temperature of 2 to 8 В° C.
It is allowed to transport the vaccine at a temperature of 25 В° C for no more than 2 days. Store in a place inaccessible to children. Shelf life of the vaccine is 2 years.
The information is provided for your information, do not self-medicate, it is dangerous for your health.

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