Universal reference book for medicines

Active substance: ferrous sulfate, folic acid, serine

Type: Anti-anemic drug

Manufacturer: Teva Pharmaceutical Industries (Israel) manufactured by MERCKLE (Germany)
Composition, form of production and packaging
longitudinally colored, one half light brown, the other dark brown, size No. 6, with a white "Aktiferrin F";
the contents of the capsules are oily pasta greyish-yellow.
1 caps.

iron sulfate monohydrate 113.85 mg,

corresponds to iron (II) 34.5 mg

D, L-serine 129 mg

folic acid 500 Ојg

Excipients: rapeseed oil - 123.96 mg, beeswax yellow - 10.33 mg, soya beans hydrogenated oil - 10.33 mg, soya beans partially hydrogenated oil - 41.32 mg, soy lecithin - 10.635 mg.

The composition of the capsule shell: sorbitol 26.95 mg, glycerol 85% 41.49 mg, gelatin 165.82 mg, iron dye black oxide (E172) -1.11 mg, titanium dioxide (E171) 0.93 mg, iron oxide yellow oxide (E172) 0.15 mg, iron dye brown oxide (E172) - 0.37 mg, ferric iron oxide red (E172) - 0.65 mg.

Ink composition: (titanium dioxide 37.96%, ethyl acetate 1.03%, shellac 26.62%, butanol 14.75%, methanol 19.64%) qs

10 pieces.
- blisters (3) - packs of cardboard.

The product description was approved by the manufacturer for the 2009 print edition.


The drug for the treatment of conditions of iron deficiency in the body, accompanied by a deficiency of folic acid.
It is also used to cover the increased need for iron and folic acid during pregnancy.
Iron is necessary for the life of the body: it is part of hemoglobin, myoglobin, various enzymes;
reversibly binds oxygen and participates in a number of oxidation-reduction reactions; stimulates erythropoiesis.
The compositum? -aminokspot-d, l-serine, which is part of Aktiferrin, promotes more efficient absorption of iron and its entry into the systemic bloodstream, leading to a rapid recovery of its normal content in the body.
This allows you to reduce the dose of iron, providing better tolerability and excluding the acute toxicity of the drug.
Pregnant women who took Aktiferrin compositum from the 22nd week of pregnancy, by the 30th week of pregnancy, found a higher content of iron in the blood than pregnant women who did not take the drug.
In newborns, the iron content in the blood is also higher in those cases when their mothers took Aktiferrin compositum during pregnancy.
Folic acid, which is part of Aktiferrin compositum, takes part in the synthesis of amino acids, nucleotides, nucleic acids;
is necessary for normal erythropoiesis.During pregnancy, performs to a certain extent a protective function in relation to the effect of teratogenic factors.
Cyanocobalamin (vitamin B 12 ) is involved in the synthesis of nucleotides;
is an important factor in normal growth, hematopoiesis and development of epithelial cells; is necessary for the metabolism of folic acid and myelin synthesis. Deficiency of vitamin B12 leads to, so-called, pernicious anemia. The satisfaction of the need for vitamin B 12 during pregnancy is crucial for the normal development of the child.

After ingestion, the iron contained in the preparation is sufficiently absorbed from the digestive tract into the systemic circulation.


- Treatment of iron deficiency anemia with concomitant deficiency of folic acid;

- Conditions accompanied by an increased need of the body in these substances, especially during pregnancy.


Capsules Aktiferrin compositum is taken orally during a meal, without chewing and washing down with a sufficient amount of water.

If the physician does not prescribe a different dosage, then follow the instructions given below.

Daily dose: 1 capsule.
Depending on the severity of the disease, the dose can be increased to 2-3 capsules / day.
After achieving normal values ​​of serum iron and hemoglobin, the drug treatment is continued for at least 4 weeks.


The occurrence of side effects should be reported to the attending physician.

Aktiferrin compositum is usually well tolerated by patients of any age.
Only in some cases, especially at high dosages and with long-term treatment, there may be slight complaints from the digestive tract (flatulence, constipation, diarrhea). With a decrease in dose, these phenomena usually disappear.
Very rarely there can be reactions of hypersensitivity to folic acid: redness of the skin, spasms of bronchial muscles, nausea, irritability, excitability, sleep disorder with nightmares.

In patients with epilepsy , convulsive seizures may become more frequent.

In some cases, there may be a loss of appetite, a bitter taste in the mouth.


- hemolytic and aplastic anemia;

- hemosiderosis, hemochromatosis;

- Sideroachrestic anemia, anemia in lead poisoning, thalassemia;

- other types of anemia, not caused by iron deficiency in the body;

- Hypersensitivity to folic acid.


The use of actiferrin compositum during pregnancy and during lactation is considered reasonable and safe.


Capsules Aktiferrin compositum is not washed down with black tea, coffee, milk to avoid reducing the absorption of iron.
In addition, a reduction in absorption can determine: solid food, bread, raw cereals, dairy products, eggs.
When taking the drug Aktiferrin compositum, staining of feces is noted in black, which is not clinically significant.


If you accidentally take especially large doses of capsules of Actyferrin Compositum (all capsules from the same package), there may be overdose phenomena.

Symptoms: abdominal pain, diarrhea, vomiting, cyanosis, confusion, symptoms of hyperventilation.

Treatment: before the specific therapy - the reception of milk, raw eggs.
Specific therapy is carried out by the appointment of deferoxamine (desferal) inside and parenterally. In acute poisoning to bind iron, not yet absorbed from the gastrointestinal tract, give inside 5-10 g of the drug by dissolving the contents of 10-20 ampoules in drinking water. To remove the absorbed iron deferoxamine is injected in / m 1-2 g every 3-12 hours.
In severe cases, accompanied by the development of shock in patients, 1 / g drip intravenous injection and symptomatic therapy.


The simultaneous use of Aktiferrin compositum and:

- antibiotics of the tetracycline series causes mutual impairment of absorption;

- antacids and cholestyramicha prevents iron absorption;

- oral contraceptives, anticonvulsants (phenytoin, primidone, barbiturates) and pyrimethamine leads to a decrease in folate levels in the blood;

- chloramphenicol interferes with the onset of the therapeutic effect of folic acid treatment;

- colchicine, neomycin, biguanides, paraaminosalicylic acid and ethyl alcohol interferes with the absorption of cyanocobalamin.


The drug is approved for use as a means of OTC.


Store at a temperature not higher than 25 В° C, out of the reach of children.
Shelf life - 60 months. Do not use after the expiration date.

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