Universal reference book for medicines
Product name: SANORIN-ANALERGINE (SANORIN-ANALERGIN)

Active substance: antazoline, naphazoline

Type: The drug with vasoconstrictive and antiallergic action for topical application in ENT practice and ophthalmology

Manufacturer: Teva Pharmaceutical Industries (Israel) manufactured by TEVA Czech Industries (Czech Republic)
Composition, form of production and packaging
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Nasal and ocular drops in the form of a transparent, colorless liquid.
1 ml

naphazoline nitrate 250 μg

antazolin mesylate 5 mg

[PRING] boric acid, sodium chloride, methylparaben, water is sterile.

10 ml - bottles of dark glass (1) with a rubber pipette "SANO" with a lid - carton boxes.

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Nasal drops are transparent, colorless, without visible mechanical inclusions.
1 f.

naphazoline nitrate 2.5 mg

antazolin mesylate 50 mg

[PRING] boric acid - 145 mg, methylparahydroxybenzoate - 10 mg, disodium edetate - 1 mg, water - up to 10 ml.

10 ml - bottles of dark glass (1) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2012.

PHARMACHOLOGIC EFFECT

Naphazoline refers to alpha 2 -adrenomimetics, has a rapid, pronounced and prolonged vasoconstrictive effect on the vessels of the mucous membrane of the nasal cavity (reduces swelling, flushing, exudation).
Relieves nasal breathing in rhinitis. After 5-7 days there is tolerance.
Antazolin - a selective blocker of H 1 -gistaminovyh receptors, has anti-allergic, anti-edematous and anti-exsudative action.

With topical application, the reduction in edema of the mucous membrane of the nasal cavity and the narrowing of the vessels occur within 10 minutes and persist for 2-6 hours.

PHARMACOKINETICS

When topical application is absorbed into the systemic circulation through the mucosa of the nasal cavity.
Data on the distribution, metabolism and elimination of the drug Sanorin-Anaerhegine is not available.
INDICATIONS

- treatment of acute rhinitis, especially allergic etiology;

- Rhinorrhea.

DOSING MODE

Adults and children over 16 years: 2-3 drops in each nasal passage 3-4 times a day.
Apply for a short time, no more than 1 week, then take a break for several days.
SIDE EFFECT

At recommended doses, the drug is usually well tolerated.
In rare cases, such adverse reactions as nausea, tachycardia, headache, pain, irritability, allergic reactions, rash, increased arterial pressure, reactive hyperemia, swelling of the nasal mucosa, local irritation may occur. With prolonged and frequent use, more than 1 week, - edema and atrophy of the mucous membrane of the nasal cavity.
CONTRAINDICATIONS

- hypersensitivity to the components of the drug;

- arterial hypertension;

- severe atherosclerosis;

- hyperthyroidism;

- age up to 16 years;

- Pregnancy;

- lactation period;

- chronic atrophic rhinitis;

- diabetes;

- tachycardia;

- simultaneous administration of monoamine oxidase inhibitors (MAO) and up to 14 days after completion of their

application.

With caution: pheochromocytoma, simultaneous treatment with drugs that raise blood pressure, use of inhalation anesthesia, which increase the sensitivity of the myocardium to sympathomimetic drugs, including halothane, bronchial asthma, prostatic hyperplasia, IHD (angina pectoris).

PREGNANCY AND LACTATION

The drug Sanorin-Anaalergin should not be used by pregnant women and nursing mothers.
In case of pregnancy, taking the drug should be stopped, in the case of taking the drug during lactation, breastfeeding should be interrupted for the entire period of treatment with the drug Sanorin-Anaerhegine.
APPLICATION FOR CHILDREN

Contraindicated in children under 16 years of age


SPECIAL INSTRUCTIONS

May have a resorptive effect.

With prolonged use, the severity of the vasoconstrictor effect gradually decreases (the phenomenon of tachyphylaxis), it is possible to develop edema of the mucous membrane of the nasal cavity with subsequent atrophy, in this connection it is recommended after 5-7 days of use to take a break for several days.

OVERDOSE

Symptoms: nervousness, decrease in body temperature, inhibition, drowsiness, bradycardia, sweating, increased blood pressure, which can be replaced by lowering blood pressure.

Treatment: symptomatic.

DRUG INTERACTION

Nafazoline slows the absorption of local anesthetic drugs (lengthens their action in the conduct of surface anesthesia).

MAO inhibitors increase the risk of development of severe arterial hypertension (release of deposited catecholamines under the action of naphazoline), slow down the metabolism of antazoline in the liver - enhance the effect.

TERMS OF RELEASE FROM PHARMACY

Without recipe.

TERMS AND CONDITIONS OF STORAGE

In the dark place at a temperature of 10 to 25 ° C.
Do not store in the refrigerator and do not freeze. Keep out of the reach of children. Shelf life - 2 years.
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