Universal reference book for medicines
Product name: PANTOGAM ACTIVE ® (PANTOGAM ACTIV)

Active substance: nonappropriate

Type: Nootropic drug with anticonvulsant action

Manufacturer: PIK-PHARMA (Russia) manufactured by PIK-PHARMA PRO (Russia)
Composition, form of production and packaging
Capsules
hard gelatinous, size 1, yellow;
the contents of the capsules are white or white powder with a yellowish hue.
1 caps.

D, L-gopantenic acid 200 mg

Excipients: microcrystalline cellulose - 13.98 mg, magnesium stearate - 1.02 mg.

The composition of the capsule shell: gelatin, glycerol (glycerin), nipagin (methylparahydroxybenzoate), nipase (propylparahydroxybenzoate), sodium lauryl sulfate, purified water, titanium dioxide, iron oxide yellow.

10 pieces.
- packings cellular planimetric (6) - packs cardboard.
15 pcs.
- packings cellular planimetric (4) - packs cardboard.
60 pcs.
- polymer cans (1) - packs of cardboard.
Capsules hard gelatinous, size №0, white flowers;
the contents of the capsules are white or white powder with a yellowish hue.
1 caps.

D, L-gopantenic acid 300 mg

Excipients: microcrystalline cellulose - 20.97 mg, magnesium stearate - 1.53 mg.

The composition of the capsule shell: gelatin, glycerol (glycerin), nipagin (methyl parahydroxybenzoate), nipase (propylparahydroxybenzoate), sodium lauryl sulfate, purified water, titanium dioxide.

10 pieces.
- packings cellular planimetric (3) - packs cardboard.
10 pieces.
- packings cellular planimetric (6) - packs cardboard.
15 pcs.
- packings cellular planimetric (2) - packs cardboard.
15 pcs.
- packings cellular planimetric (4) - packs cardboard.
30 pcs.
- polymer cans (1) - packs of cardboard.
50 pcs.
- polymer cans (1) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2010.

PHARMACHOLOGIC EFFECT

The action of Pantogam is related to the presence of gamma-aminobutyric acid in its structure, which directly affects the GABA B- receptor-channel complex.Pantogam, the active is a racemic mixture of equal amounts of the R form of gopanthenic acid and its S-isomer.
The presence of the isomer improves the transport and interaction of the drug with the GABA receptor. Pantogam asset has a more pronounced nootropic and anticonvulsant action than preparations of first-generation hapantenic acid.
Pantogam is an active that increases the resistance of the brain to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines moderate sedation with a mild stimulating effect.
Has an anti-asthenic and light anti-anxiety effect. Reduces motor excitability, organizes behavior. Activates mental activity and performance. It causes inhibition of the pathologically increased vesicle reflex and detrusor tone.
PHARMACOKINETICS

Quickly absorbed from the digestive tract.
Penetrates through the blood-brain barrier. It is not metabolized and is excreted unchanged for 48 hours: about 70% of the dose taken with urine, about 30% with feces.
INDICATIONS

- cognitive impairment with organic brain lesions (including the consequences of neuroinfections and craniocerebral trauma) and neurotic disorders;

- cerebrovascular insufficiency, caused by atherosclerotic changes in cerebral vessels;

- extrapyramidal hyperkinesis (myoclonus-epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease and others), as well as for the treatment of extrapyramidal syndrome caused by the administration of neuroleptics;

- with epilepsy in conjunction with anticonvulsants;

- psycho-emotional overload, reduced mental and physical performance, to improve concentration and memorization;

- neurogenic disorders of urination (pollakiuria, imperative urges, mandatory urinary incontinence, enuresis);

- with schizophrenia in complex therapy.

DOSING MODE

Inside, 15-20 minutes after meals, 2-3 times / day preferably in the morning and afternoon.

Capsules 200 mg - 1-4 capsules (0.2-0.8 g).
The maximum daily dose is 12 capsules (2.4 g).
Capsules 300 mg - 1-3 capsules (0.3-0.9 g).
The maximum daily dose of 8 capsules (2.4 g). The course of treatment is 1-4 months, sometimes up to 6-12 months. After 3-6 months, a repeat course of treatment is possible.
SIDE EFFECT

In rare cases, allergic reactions are possible (rhinitis, conjunctivitis, skin rashes).
In this case, reduce the dose or cancel the drug. Sleep disturbances or drowsiness, noise in the head - these symptoms are usually short-lived and do not require withdrawal of the drug.
CONTRAINDICATIONS

- Acute severe kidney disease;

- Pregnancy (I trimester);

- lactation;

- the age of the patient is under 18 (there are no clinical studies on the use of the drug at this age);

- Hypersensitivity.

PREGNANCY AND LACTATION

The drug is contraindicated in pregnancy (I trimester) and during lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindicated in acute severe kidney disease.

APPLICATION FOR CHILDREN

Contraindicated in children under 18 years of age.
There are no clinical studies on the use of the drug at this age.
SPECIAL INSTRUCTIONS

In the conditions of long-term treatment, simultaneous administration of the drug with other nootropic and CNS-stimulating agents is not recommended.

OVERDOSE

Increased symptoms of side effects.

Treatment: activated charcoal, gastric lavage, symptomatic therapy.

DRUG INTERACTION

Prolongs the effect of barbiturates, enhances the effects of anticonvulsants, prevents side effects of phenobarbital, carbamazepine, neuroleptics.

The Pantogam effect is intensified when combined with glycine, etidronic acid.

Potentsiruet action of local anesthetics (procaine).

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug is stored in a dry, dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.
Shelf life - 3 years.
Do not use after the expiration date printed on the package.
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