Universal reference book for medicines
Product name: MAGNESIUM PLUS B6 (MAGNESIUM PLUS B6)

Active substance: magnesium lactate, pyridoxine

Type: A drug that replenishes magnesium deficiency in the body

Manufacturer: ВАЛЕНТА ФАРМАЦЕВТИКА (Russia)
Composition, form of production and packaging
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Tablets, film-coated 1 tab.
magnesium lactate dihydrate 470 mg

pyridoxine hydrochloride 5 mg

10 pieces.
- packings cellular planimetric (5) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2010.

PHARMACHOLOGIC EFFECT

Combined drug that replenishes magnesium deficiency.

Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells, participates in many metabolic reactions.Magnesium ions reduce the excitability of neurons, play an important physiological role in maintaining the ion balance in muscles (slow down the neuromuscular transmission), participate in many enzymatic reactions.
The lack of magnesium in the body can be observed with a violation of diet (diet) or with increasing demand for magnesium (with increased physical and mental stress, stress, pregnancy, the use of diuretics).
Pyridoxine (vitamin B6) is a coenzyme of the metabolism of amino acids and proteins, is involved in the regulation of the metabolism of the nervous system.Phosphorylated and in the form of pyridoxal phosphate is part of the enzymes that catalyze decarboxylation and reamination.
It plays an important role in the metabolism of tryptophan, glutamic acid, cysteine, methionine, and also in the transport of amino acids through the cell membrane. It is necessary for the activation of phosphorylase, for the formation of neurotransmitters, gamma-aminobutyric acid, glycine, serotonin. Participates in the exchange of vitamin B and, folic acid, in the synthesis of porphyrins, in the exchange of unsaturated fatty acids. Improves the absorption of magnesium from the digestive tract and its penetration into the cells.
Magnesium content in serum:

- from 12 to 17 mg / l (0.5-0.7 mmol / l) indicates a moderate magnesium deficiency;

- below 12 mg / l (0.5 mmol / l) indicates a severe magnesium deficiency.

PHARMACOKINETICS

Absorption of magnesium in the gastrointestinal tract is no more than 50% of the dose taken internally.
In the body, magnesium is distributed mainly in the intracellular space (about 99%), of which about 2/3 is distributed in the bone tissue, and a third is in the smooth and striated muscle tissue. It is excreted mainly by the kidneys. Magnesium present in the urine, on average, is 1/3 of the dose taken.
Pyridoxine is easily absorbed by simple diffusion throughout the small intestine, more is absorbed in the jejunum.
Well penetrates into all tissues. The greatest concentrations of vitamin are found in the liver and myocardium. Lower concentrations are found in the muscles and CNS. Metabolized in the liver with the formation of pharmacologically active metabolites (pyridoxal phosphate and pyridoxamine phosphate).
Pyridoxal phosphate with plasma proteins binds to 90%.
Penetrates through the placenta, is secreted with breast milk. It is excreted by the kidneys. T 1/2 - 15-20 days.
INDICATIONS

A fixed deficiency of magnesium, isolated or associated with other deficient conditions, accompanied by symptoms such as:

- increased irritability;

- minor sleep disorders;

- Gastrointestinal spasms or heart palpitations;

- increased fatigue;

- pain and muscle spasms;

- tingling sensation.

DOSING MODE

Before taking the drug, you should consult your doctor.

Adults are recommended to take 6-8 tablets / day;
children over 6 years (body weight over 20 kg) - 4-6 tablets / day.
The daily dose should be divided into 2-3 doses, taken with food, washed down with a glass of water.

On average, the duration of treatment is 1 month.

Treatment should be stopped immediately after the normalization of the magnesium level in the blood.

SIDE EFFECT

Allergic reactions.

From the digestive system: abdominal pain, constipation, nausea, vomiting, flatulence.

Perhaps the development of hypermagnes.
Early signs and symptoms of hypermagnesemia: bradycardia, diplopia, sudden flush of blood to the skin of the face, headache, decreased blood pressure, nausea, dyspnea, blurred speech, vomiting, weakness, with kidney failure - dizziness


CONTRAINDICATIONS

- marked renal failure (creatinine clearance less than 30 ml / min);

- phenylketonuria;

- deficiency of lactase;

lactose intolerance;

- glucose-galactose malabsorption;

- hypermagnesia;

- children's age till 6 years;

- Hypersensitivity to the components of the drug.

With caution: with moderate failure of kidney function (risk of hypermagnesemia).

PREGNANCY AND LACTATION

Magnesium plus B6 can be used during pregnancy only as directed by a doctor.

It is not recommended to take the drug during lactation (magnesium and pyridoxine derivatives penetrate into breast milk).

APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindicated:

- marked renal failure (creatinine clearance less than 30 ml / min).

APPLICATION FOR CHILDREN

Contraindicated in children under 6 years.
Children older than 6 years (body weight over 20 kg) - 4-6 tablets / day.
SPECIAL INSTRUCTIONS

With concomitant calcium deficiency, magnesium deficiency should be eliminated before the introduction of additional calcium intake.

With frequent use of laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to the development of a deficiency of magnesium in the body.

OVERDOSE

With normal kidney function, oral magnesium intake does not cause toxic reactions.
Magnesium poisoning can develop with kidney failure. Toxic effects mainly depend on the magnesium content in the blood serum.
Symptoms: decreased blood pressure, nausea, vomiting, slow reflexes, ECG changes, respiratory depression, coma, cardiac arrest and paralysis of the heart, anuria.

Treatment: rehydration, forced diuresis.
As an antidote for an overdose of magnesium (hypermagnesium), calcium preparations (as a magnesium antagonist) - calcium chloride or calcium gluconate - are used. With renal failure, hemodialysis or peritoneal dialysis is necessary.
DRUG INTERACTION

Magnesium plus B6 is preferably not administered concomitantly with phosphate or sodium compounds,
can significantly reduce the absorption of magnesium in the digestive tract.
Magnesium preparations reduce the absorption of tetracycline, with simultaneous admission it is recommended to make an interval of 3 h before using Magnesium plus B6.

Magnesium weakens the effect of oral anticoagulants (including coumarin and indanedione derivatives), reduces the absorption of iron.

Vitamin B6 reduces the pharmacological effects of levodopa.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

Store the drug in a dry, dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children. Shelf life - 2 years. Do not use after the expiration date.
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