Universal reference book for medicines
Product name: CANDIBIOTIC (CANDIBIOTIC)

Active substance: comb.
drug
Type: The drug with antibacterial, antifungal, anti-inflammatory and local anesthetic action for topical application in ENT practice

Manufacturer: GLENMARK PHARMACEUTICALS (India)
Composition, form of production and packaging
Ear drops
in the form of a transparent liquid of light yellow color.

1 ml

beclomethasone dipropionate 250 μg

chloramphenicol 50 mg

clotrimazole 10 mg

lidocaine hydrochloride (in the form of monohydrate) 20 mg

Excipients: glycerol, propylene glycol.

5 ml - bottles of dark glass (1) complete with a pipette - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2016.

PHARMACHOLOGIC EFFECT

Combination drug for topical application in ENT-practice.

Clotrimazole is a broad-spectrum antifungal agent for topical use, an imidazole derivative.
The antifungal effect of clotrimazole is associated with a disruption in the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis.
Chloramphenicol is a bacteriostatic broad-spectrum antibiotic.
Disrupts the process of protein synthesis in a microbial cell. It is active against gram-positive and gram-negative bacteria.
Beclomethasone dipropionate - GCS.
Has anti-inflammatory and anti-allergic effect.
Lidocaine hydrochloride - a local anesthetic, causes a reversible blockade of impulse conduction through nerve fibers due to blockage of the passage of sodium ions through the membrane.

PHARMACOKINETICS

Studies of pharmacokinetics of the drug Kandibiotic have not been conducted.

INDICATIONS

Allergic and inflammatory diseases of the ear, including:

acute and diffuse otitis externa;

acute otitis media;

- chronic otitis in the acute stage;

- condition after surgical interventions on the ear.

DOSING MODE

The drug is instilled in the external ear canal for 4-5 drops 3-4 times / day.
Improvement of the condition occurs within 3-5 days. The course of treatment is 7-10 days.
SIDE EFFECT

Local reactions: rarely - itching, burning in the place of application.

Other: allergic reactions.

CONTRAINDICATIONS

- violation of the integrity of the tympanic membrane;

- children's age till 6 years;

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

The question of the expediency of prescribing the drug during pregnancy is decided by the doctor individually.
The purpose of the drug is possible in the event that the intended benefit of therapy for the mother exceeds the potential risk to the fetus.
Data on the safety of the drug during lactation (breastfeeding) are not provided.

APPLICATION FOR CHILDREN

Contraindication: children under 6 years.

OVERDOSE

Data on the drug overdose Kandibiotic are not provided.

DRUG INTERACTION

Drug interaction of the drug Kandibiotic has not been studied.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a dry, dark place at a temperature of no higher than 25 ° C.
Shelf life - 2 years.
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