Universal reference book for medicines
Product name: CANDID (CANDID)

Active substance: clotrimazole

Type: Antifungal agent for topical application in gynecology

Manufacturer: GLENMARK PHARMACEUTICALS (India)
Composition, form of production and packaging
?
The gel is vaginal homogeneous, white in color.
1 g

clotrimazole 20 mg

Excipients: cetyl alcohol, propylene glycol, glycerol, benzyl alcohol, cetomacrogol emulsion wax, carbopol 940 (carbomer 940), sodium hydroxide, chlorocresol, purified water.

30 g - aluminum tubes (1) complete with applicator - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2008.

PHARMACHOLOGIC EFFECT

The drug with a wide range of antifungal effects for topical application in gynecology.
The mechanism of antifungal action of clotrimazole (an imidazole derivative) is associated with a disruption in the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis. In low concentrations it acts fungistatically, and in high concentrations it acts fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.
It is active against dermatophytes, yeast-like and mold fungi, as well as the causative agent of the multi-colored lichen (Pityriasis versicolor) and the causative agent of erythrasma.
Has antimicrobial effect against Gram-positive (staphylococcus, streptococcus) and Gram-negative bacteria (Bacteroides, Gardneretla vaginalis), and also against Trichomonas vaginalis.
PHARMACOKINETICS

With intravaginal administration, the absorption of clotrimazole is 3-10% of the administered dose.
High concentrations in the vaginal secretion and low concentrations in the blood persist for 48-72 hours. In the liver, clotrimazole is rapidly metabolized to inactive metabolites.
INDICATIONS

Candidiasis vulvovaginitis;

- Trichomoniasis;

- genital superinfections caused by microorganisms sensitive to clotrimazole.

DOSING MODE

The drug is intended for intravaginal use only.

A full applicator with a gel (about 5 g of the drug) is injected into the vagina, in the supine position and slightly bent legs, every evening for 6 days.
Repeated course of therapy is possible only according to the doctor's prescription.
SIDE EFFECT

On the part of the reproductive system: itching, burning, flushing and edema of the mucous membrane of the vagina, discharge from the vagina, a burning sensation in the penis at the sexual partner, pain in the vagina during intercourse.

From the side of the urinary system: frequent urination, intercurrent cystitis.

Other: headache, gastralgia.

CONTRAINDICATIONS

- the period of menstruation;

- I trimester of pregnancy;

- Hypersensitivity to clotrimazole or other components of the drug.

With caution appoint the drug during lactation.

PREGNANCY AND LACTATION

In clinical and experimental studies it has not been established that the use of the drug in the II and III trimester of pregnancy or lactation (breastfeeding) has a negative effect on the health of a woman or fetus (child).
However, the question of the appropriateness of prescribing the drug should be decided individually after consulting a doctor.
If it is necessary to use the drug during pregnancy, the gel should be administered without the use of an applicator.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Patients with hepatic insufficiency should periodically monitor the functional state of the liver.

SPECIAL INSTRUCTIONS

To prevent urogenital reinfection, it is necessary to simultaneously treat sexual partners.

When trichomoniasis concurrently with Candida, it is recommended to use systemic drugs (for example, metronidazole inside).

Patients with hepatic insufficiency should periodically monitor the functional state of the liver.

When signs of hypersensitivity or irritation appear, the treatment is stopped.

Avoid getting the drug on the mucous membrane of the eyes.

If there is no effect within 4 weeks, you should confirm the diagnosis.

OVERDOSE

The use of the drug in elevated doses does not cause any reactions and conditions that are life-threatening.

DRUG INTERACTION

With vaginal administration, clotrimazole reduces the activity of amphotericin B and other polyene antibiotics.

When used simultaneously with natamycin and nystatin, the activity of clotrimazole may decrease.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a place protected from light, inaccessible to children, at a temperature of no higher than 25 ° C;
Do not freeze. Shelf life - 3 years.
Alphabetical index of medicines:
A  B  V  G  D  E  J
Z  I  Y  K  L  M  N
O  P  R  S  T  U  F
H  C  CH  SH  E  U  Y
Rambler's Top100
Privacy policy:
Copyright 2009 - 2017. Universal reference book of medicines. All rights reserved.
When using site materials, an active hyperlink is required!