Tireoidin (thyreoidinum)


TIREOIDIN (Thyreoidinum).
     Hormonal drug, derived from the dried obezzhirennyh schitovidnyh iron butcher cattle.
     Synonyms : Thyranon, Thyroid, Thyrotan.
     Powder yellow-grey with low odor characteristic of dried animal tissue. Nerastvorim in water, alcohol and other solvents.
     Has biological activity of thyroid hormone.
     Standardizes on organically bound iodine content (from 0.17 to 023%).
     Step tireoidina linked to the existence of two hormones : tiroksina and triyodtironina (in the body are both levovraschayuschimi isomers).
     Tiroksin chemically different from triyodtironina molecules in the presence of one additional atom of iodine.
     Both hormones have a similar impact on the multi-organism, increase tissue oxygen demand, increase energy processes, promote the growth and differentiation of tissues, affecting the functional state of the nervous and cardiovascular systems, liver, kidneys and other organs and systems, increased glucose intake and reclamation. Effect tireoidnyh hormones may vary depending on the dose. For example, low doses tiroksina have anabolic effects, the same high doses lead to increased degradation of protein. In high doses Thyroid hormones inhibit tireotropnuyu active glands.
     Triiodothyronine in 3 - 5 times more effective than tiroksin and act quickly, because the protein binds less blood is transported in the blood mainly in the form of free and quickly crosses the cell membrane. The latent period triyodtironina is 4 to 8 h and tiroksina 24-48 h.
     Currently Triiodothyronine obtained by synthetic; Its use as a standalone drug treatment (see Triyodtironina hydrochloride).
     Tireoidin and appoint Triiodothyronine (in relatively small doses), with the lack of thyroid function in higher doses (not cause hyperthyroidism, but sufficient to suppress tireotropnoy activity), with the excess tireotropnoy pituitary function. The main reasons for their use are primary hypothyroidism and miksedema, cretinism, gipofizarnye cerebrovascular diseases occur with hypothyroidism, with the phenomena of obesity hypothyroidism, and sporadic endemic goitre, thyroid cancer.
     Tireoidin has gipoholesterinemicheskoe effect in patients with atherosclerosis. Mechanism of action is, apparently, with stimulation catabolised cholesterol. Clinical application tireoidina for this purpose, however, is limited because of a possible increase in patients with strokes.
     Assign tireoidin inside. Doses should carefully indivilualizirovatsya patient's age, the nature and course of the disease. Is inwards in the morning after eating.
     Adults with miksedeme and hypothyroidism appointed first 0.05 - 0.2 g / day of preparation, and then specify the dose, seeking normalization pulse, the main exchange, blood cholesterol. In diffuse eutireoidnom sporadic and endemic goitre dose ranged from 0.1 to 0.2 grams per day, and then in the treatment of smaller gland to reduce the daily dose of 0,05 - 0,1 g.
     Patients with thyroid cancer (after surgical removal of the tumor and radiation therapy) to designate 0.2 - 0.3 g / day tireoidina (distant metastases, with up to 1 g or more per day). When toxic goitre take of 0.05 grams a day to 0.15 - 0.2 g / day (with antitireoidnymi drugs).
     Higher doses for adults inside : single 0.3 g, 1 g daily; For children under the age of 6 months : single 0.01 g, 0.03 g daily; From 6 months to 1 year : single 0.02 grams daily 0.06 g; at the age of 2 years : single 0.03 g, 0.09 g daily; 3 to 4 years : single 0.05 g, 0.15 g daily; 5 - 6 years : single 0,075 g, 0.25 g daily; 7 to 9 years : single 0.1 g, 0.3 g daily; 10 to 14 years : a single 0.15 grams daily 0.45 g.
     Children under the age of 1 year shall pellets (mixed with 2 - 3 spoons of water or kissels).
     In miksedeme and hypothyroidism children designate doses close to the top, clarifying them, depending on the clinical course of the disease and the effectiveness of therapy.
     Usually a tireoidina was already after 2 or 3 days of treatment, the final effect is observed after 3 to 4 weeks.
     Tireoidin be applied under close medical supervision. When possible overdose phenomenon thyrotoxicosis (frequency pulse, heartbeat, sweating, etc.), strokes, diabetes deteriorated during etc.
     Contraindications with thyrotoxicosis (expressed clinical picture), diabetes, addisonovoy disease, the overall depletion of large, severe forms of coronary insufficiency.
     Method of issuance : powder; Pills to 0.05 g, as well as tablets, coated on 0.1 and 0.2 g; Beads and disposable packages of 0.01 g (granules for children : Thyreoidinum granulae pro infantibus).
     Storage : List B. The well ukuporennyh banks dark glass in a dry, cool place; Granules-dry at a temperature no higher than + 25 C.

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