Segidrin (sehydrin)


Segidrin (Sehydrin)
     Synonym: Hydrazine sulfate, Hydrazine sulfate
     Description drug forms: tablets covered with skin infection soluble red-brown color, kernel-white. On cross section showed two layers.
     Pharmacological Effects: Protivoopuholevoe.
Slowing growth of tumor cells. Affects several biochemical processes: inhibited MAO reduces the permeability of cell membranes and cell organell, inhibited ksenobiotikov metabolism. Assists with symptomatic of malignant tumors in the late stages.
     Pharmacokinetics: After the reception inside the dose of 60 mg C max blood sick achieved in 2 hours Sampling at 9 h after the 30-day course of treatment for blood found between 0 and 89 ng / ml SEHYDRIN. Drops in the liver, kidney and lung levels 3-5 times higher than concentrations in the blood. In the body exposed to oxidation, with urine output, partly in the form atsetilirovannoy (according to the experimental data obtained in rats and rabbits). Withdrawal from the urine of healthy animals until three days and about 50% of the entered numbers (from pests opuholenositeley withdrawal ends between the first and second days, with only the 25% product). 's Propensity for cumulation in the body opuholenositeley pests.
     Clinical pharmacology: Vyrazhennoe symptomatic effect is the reduction or disappearance of more (up to non-narcotic analgesics), a sense of weakness, respiratory distress events (short, cough), fever, appetite improved, enhancing engine activity. There has mielodepressivnym action.
     Indications: Mestno- disseminirovannye and common form of malignant neoplasms, including in patients with tsitopeniey caused by chemotherapy and radiation therapy and jaundice, especially obturatsionnoy due to metastases in the liver, including far-coming stage, including preterminalnuyu phase (for better feeling and mood).
     Contraindications: Hypersensitivity.
     Application of pregnancy and breast feeding: The use of the drug in pregnant and lactating women are not investigated.
     Adverse actions: Dispepticheskie events, including nausea, vomiting, AI (pass at lower doses or 2-3-day break for treatment), seldom-insomnia, general arousal polinevrita display symptoms.
     Networking: Simultaneous reception with barbiturates led to the development of toxic effects.
In experiments on laboratory animals showed that a reception SEHYDRIN enhances many ANTITUMOR drugs (tsiklofosfan exception).
     Dosing and Administration: inside, for 1-2 h before eating or 1-2 h after the meal (or receiving other drugs) for Table 1. three times a day, with poor portability - 2 tablets. a day; rate-100 tablets. Re course conducted at intervals of not less than 14 days; The number of courses is not limited to, and the intervals between courses increased by 1-2 weeks.
     Precautions: The use of drugs in children are not investigated. With caution and under constant surveillance doctor appointed violations as expressed in the liver and kidneys. During treatment excludes any use of alcohol and barbiturates intake (due to a sharp increase toxicity).
     Special instructions: If you have diarrhoea phenomena appointed interior courses and anti-money (tincture chamomile, romazulan, vikalin), and spazmolitiki antiemetiki (pyridoxine, tserukal etc.), the development neyrotoksicheskih effects, pyridoxine (5% solution of 1 ml / m 1-2 times daily), tiamina chloride (vitamin B1), multivitamin preparations (interference), in / in-20-40% glucose solution.
     Best before: 3 years
     Storage conditions: List B. In a dry, sheltered from the world scene

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