Linestrenol (lynestrenol)

LINESTRENOL (Lynestrenol).
     (17?) -19 - Norpregn-4- en-20- in-17- role.
     Synonyms : Orgametril, Ekslyuton, Exluton, Orgametril.
     Has gestannoe and weak androgennoe effect.
     Quickly and completely absorbed in the digestive tract, A max is 2 h; Being in the liver biotransformation education noretisterona active metabolite (see), allocated mainly kidneys.
     Applied with dysfunctional matochnyz krovotecheniyah, amenorrhea and oligomenoree, endometriosis, mastopatii, pre syndrome, carcinoma endometrium.
     Assign inside : with endometriosis and dysfunctional uterine krovotecheniyah for 0,005-0,015 grams (5-15 mg) per day for at least 6 months; When amenorrhea (after training estrogen) on 0,005-0,01 g (5-10 mg) a day during the second half of the cycle; in pre-syndrome of 0,005 grams (5 mg) daily from 14 th to the 25 th day cycle; for contraception for 0.0005 g (0 , 5 mg) a day; when carcinoma endometrium on 0,03-0,05 g (30-50 mg) a day.
     Possible side effects : nausea, diarrhea, depression, anxiety, increased body mass, skin, the skin itch.
     The drug is not suitable for serious violations of the liver, uterine krovotecheniyah unknown etiology, otosclerosis, arterial hypertension, heart failure, depression, thromboembolitic complications insulinzavisimom diabetes (reduces tolerance to glucose).
     Product : pills to 0,0005 and 0,005 grams (0.5 and 5 mg) (N. 28 and 30 respectively).
     Storage : List B.

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