Loperamide (loperamidum)

LOPERAMID (Loperamidum). 4 - (4-Hlorfenil) -4 - oksi-N, N - dimethyl-aa-difenil-1- piperidin- butanamida hydrochloride.
     Synonyms : Imodium, Capent, Diacure, Diaremide, Donafan, Election, Enterol, Entosec, Imodium, Imosec, Lopemid, Loperan, Loperamide hydrochloride, Lormide, Motilan, Normotil, Obstar, Oldon, Regulane, Suprasec, Vacontil, Viltar and others.
     White powder odourless, bitter taste.
     On chemical structure similar to the product fenilpiperidina has similarities with analgetikami fentanyl and piritramidom (see), but expressed analgesic effects loperamide not help. However, he actively inhibits peristaltiku intestines, which is one of the characteristics of opiates. In an experiment loperamide associated with opioid receptors; It is possible that the binding of these receptors in the intestinal tissue antidiarrhoeal determine its effect.
     Loperamide applied as a means of symptoms in acute and chronic diarrhea.
     Assign into adults with acute diarrhea first 0,004 grams (4 mg capsules = 2), then after each liquid chair of 0,002 grams (1 capsule). Children older than 5 years are beginning 1 capsule (0,002 grams), and then also on 1 capsule after each chair.
     When adults have chronic diarrhea first 0,004 g, followed by 0.002 g of 1 to 6 times a day; Children older than 5 years are designated first 0,002 grams, and then also to 0,002 g 1 - 3 - 5 times day.
     Children aged 1 to 5 years of preparation are in the form of solution containing 0.2 mg in 1 mL of 1 teaspoonful (5 ml) for 10 kg of body weight 2 to 3 times a day. Children under the age of 1 year product is not appointed.
     In applying loperamida (often long) can constipation, nausea, dizziness. In these cases, stop receiving the drug.
     Do not appoint loperamide together with atropine and other drugs holinoliticheskimi (to avoid mutually reinforcing effects).
     Method of issuance : 2 mg capsules (0,002 grams) in a package of 10 pieces; 0.002% solution loperamida in bottles of 100 ml (0.2 mg in 1 mL).
     Storage : List B. In the dark spot.

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