Levorin (levorinum)

LEVORIN (Levorinum).
     Antibiotics, produtsiruemy Actinomyces levoris Krass. Refers to a group polienovyh antibiotics.
     Dark yellow powder without the smell and taste. Gigroskopichen. Easily destroyed by the action of acids and alkalis, as well as light. Almost nerastvorim in water and alcohol.
     Has chemotherapeutic activity against pathogenic fungi drozhzhepodobnyh in particular fungus Candida. In some cases, a failure in clinical nystatin.
     Activity is expressed in units of action. At 1 mg contains 25000 ED.
     Applied levorin local and inside.
     In paronihii, mezhpaltsevyh erosion and damage skin wrinkling caused by drozhzhepodobnymi mushrooms, apply ointment (see Maz levorinovaya). Cuticles stricken place 1 to 2 times a day for 7 to 10 days.
     In oral mucosal diseases caused by fungi drozhzhepodobnymi, levorin designate (adults) as a water mist (1:500) to rinse; Apply 2 to 3 times a day for 15 to 20 days. Suspended not being inhaled. In a similar mist used to soak levorin tampons in treating diseases mucous membranes of the genitals of women; Treatment of 15 - 20 days. Indications are uterine bleeding.
     In candidiasis gastrointestinal tract and intestinal kandidanositelstve designate levorin inside adult for the 500000 ED in the form of tablets or capsules 2 to 4 times a day for 10 to 12 days, children up to 2 years in the 25000 - 30000 ED / kg day, from 2 to 6 years in the 20000 - 25000 ED / kg / day, over six years, the occasional dose ED 200000 - 250000 2 - 4 times a day. The course of treatment 7-14 days.
     The treatment can be repeated after a 5-to 7 days (by blood).
     In oral mucosal candidiasis and kandidanositelstve and candidiasis in the gastrointestinal tract can be used hominids (transbukkalnye) tablets, which contain 500000 ED antibiotic. Pills sutures in his mouth for 10 to 15 minutes. Adults appoint one pill 2 to 4 times a day, for children from 3 to 10 years - 1 / 4 pills (ED 125000) 3 - 4 times a day, between 10 and 15 years old-1 / 2 tablets (ED 250000) 2 - 4 times a day, over 15 years are adult dose of 2 to 4 times a day.
     Duration of treatment is the same as conventional tablets or capsules used inside.
     Children levorin can appoint a suspension, which is preparing for the suspension of the powder. By content bottle powder slurry (levorina content in the vial 2000000 or 4000000 ED) added prokipyachennuyu chilled water to the markings on the bottle. A mixture of mixed before use vzbaltyvayut. One teaspoonful (5 ml) contains 100000 ED. In March 2000 a drop of suspension ED.
     Suspension appointed to the same doses (pro - ED), as tablets or capsules inside.
     For treating candidiasis female genital organs can be used vaginal suppositories (tablets), containing 250000 ED levorina. Tablets introduce the vagina after douching 0.5-1% solution of sodium gidrokarbonata and drying Cotton marlevym tampon. Pre-moistened with distilled tablets or boiled water and impose a 1 - 2 2 pieces per day at the rear of the set. The course of treatment of at least 14 days. If necessary, after 2 to 3 weeks to re-rate, which priurochivayut to poslemenstrualnomu period.
     There have been some performance levorina with prostate gland adenoma (decrease dizuricheskih events, subjective improvement, and in some cases, and the reduction of adenoma). Taking into tablets or capsules daily in the first 2 weeks of ED 500000 3 times a day and then on 500000 ED four times a day. The course of treatment 3 months. After 10 to 15 days of treatment can be repeated.
     The reception inside levorina possible nausea, skin lesions, dermatitis, breaks a chair. If necessary, designate protivogistaminnye drugs; When expressed adverse events temporarily stop receiving the drug. Recommended complex vitamins B, ascorbic acid.
     Levorin contraindications to liver diseases, diarrhoeal diseases negribkovoy etiology, gastric ulcers and duodenal ulcers, with the pregnancy. During treatment should monitor the liver.
     Method of production : 500,000 tablets of ED (for the reception inside; Tabulettae Levorini 500000 ED; Pill yellow or dark yellow in a package of 25; 50 or 100 pieces); Pill hominids on ED 500000 (500000 ED Tabulettae Levorini transbuccales ; pill brown, sweet taste, with the smell of cocoa and vanillin in a package of 25 and 40 pieces); powder for cooking suspension, for the treatment of children with powder for cooking mist exterior (rinse, soak tampons); ointment; tablets vaginal (ED 250000).
     To prepare suspended (1:500) exterior to 2 g levorina add 20 mL of 95% ethanol. After 5 to 10 minutes in alcohol suspended in the handling front, containing 300 to 400 ml of distilled water, and mixed with water to bring the total to 1000 ml. Vstryahivayut suspended for 10 minutes. Prepare it the day of application; Vzbaltyvayut before consumption.
     Ointments levorinovaya (Unguentum Levorini). Ointments light brown to lanolinovo- vaseline basis; Contains 500000 ED levorina in 1 year
     Bears on skin areas affected 1 to 2 times a day for 10-15 days or more. At the same time, appoint or capsules levorina.
     Product : in the box on 30 and 50 g.
     Storage : List B. Powder and all dosage forms levorina remain in the dark place at a temperature not exceeding+  4 C.

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