Etaperazin (aethaperazinum)

ETAPERAZIN (Aethaperazinum). Hlor-10- 2 - (3-[1-(b-oksietil) - piperazinil-4] - propyl) - fenotiazina digidrohlorid.
     Synonyms: Perfenazin, Chlorpiprazin, Chlorpiprozine, Decentan, Fentazin, Neuropax, Perphenan, Perphenazini hydrochloridum, Perphenazine hydrochloride, Trilafon, Trilifan etc.
     White or white with a grayish tinge barely noticeable crystalline powder. Easy soluble in water, little of alcohol. Gigroskopichen. Powder and aqueous solutions decomposed by the action of light.
     On chemical structure differs from meterazina with a nitrogen atom in the position 4 piperazinovogo kernel oksietilnoy instead of methyl groups.
     Etaperazin an active adjunct substances. It is much more active than aminazin on protivorvotnomu action and the ability to reassure ikotu. Provides relaxation of the disorders. Several smaller than aminazin, potentsiruet of rape, drugs and other substances that have a negative impact on the nervous; Gipotermicheskoe action expressed in a weak degree; On adrenoliticheskoy activity aminazinu slightly lower. Provides kataleptogennoe effect.
     By virtue of superior antipsihoticheskogo aminazin and approaching triftazinu. Due to strong antipsihoticheskoy etaperazin activity can be effective in patients resistant to aminazinu. Antipsihoticheskoe action combined with a etaperazina expressed trigger influence and impact on the election syndromes, of ongoing with the slow, sluggish, apathy, especially with substuporoznymi phenomena, as well as apatoabulicheskie condition.
     Etaperazin can also be used with neuroses, accompanied by fear, stress, etc.
     One of the most important indication for use etaperazina are uncontrollable vomiting and Hiccup. As protivorvotnoe tool used after surgical treatment for abdominal organs, with radiation and chemotherapy of malignant neoplasms, etc.
     In practice, sometimes combined with the skin itching designate.
     Etaperazin appointed interior in the form of tablets after eating. Persons with mental illnesses who were not previously lechivshimisya brain to establish initial dose of 0,004 - 0,01 g (4 - 10 mg), 1 to 2 times a day. In instituting and rapid growth psihoticheskih phenomena daily dose can be as high as 30-40 mg. In the future, gradually increasing the dose, selecting her individually for each patient. For patients, the first new treatment for brain, the optimal daily intake is usually 50-80 mg (2 - 3 admission). Patients with a chronic illness to bring the daily dose of 0.1 - 0.15 g, and particularly resistant cases up to 0.25 - 0.3 g (0.4 g sometimes). The duration of treatment ranged from one to four months or more. Supporting the therapeutic dose, usually 0.01 - 0.06 g (10-60 mg) per day.
     Etaperazinom treatment can be combined with other psychotropic drugs.
     In obstetrics, surgical, medical and oncological practice in the application as protivorvotnogo funds, as well as neuroses etaperazin appoint 0,004 - 0,008 grams (4 to 8 mg), 3 to 4 times a day.
     Etaperazin postponed usually better than aminazin: fewer expressed confusion, slow, weak. But etaperazin also can cause side effects and neurological somatic nature (see: Aminazin).
     Contraindications: the same as for aminazina.
     Form release: pills to 0,004; 0.006 and 0.01 g (4; 6, and 10 mg), thickly coated yellow, in a package of 50; 100 and 250 pieces.
     Storage: List B. In a dry, sheltered from the world scene.

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