Universal reference book for medicines

Active substance: cefpirome

Type: Cephalosporin IV generation

Manufacturer: SIMPEX PHARMA (India)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

Antibiotic cephalosporin series IV generation.
Has a bactericidal effect by inhibiting the synthesis of mucopeptides of the bacterial cell wall in the phase of mitosis.Has a wide spectrum of action against gram-positive and gram-negative bacteria, strains resistant to aminoglycosides or cephalosporin antibiotics of the third generation.
It is active against Gram-positive bacteria: Staphylococcus aureus, Staphylococcus spp., Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Corynebacterium spp., Peptostreptococcus spp .;
Gram-negative bacteria: Pseudomonas aeruginosa, Escherichia coli, Enterobacter spp., Klebsiella spp., Proteus spp., Morganella morganii, Providencia spp., Citrobacter spp., Serratia spp., Haemophilus influenzae, Moraxella catarrhalis, Acinetobacter spp., Bacteroides spp.
Cephpir is not absorbed from the digestive tract.
After iv introduction at a dose of 1 g for 5 minutes, the average concentration in the blood plasma is 81 mg / l.Binding to plasma proteins is about 10%.
T 1/2 of cefpyroma in patients with normal renal function is about 1.8-2.2 hours. Cumulation with repeated administration is not observed.
Cephpir is excreted mainly by the kidneys through glomerular filtration. In the first 24 h urinary excretion is 80-90%.
In patients over the age of 65 years, within 5 min after iv introduction at a dose of 1 g, the average concentration in the blood plasma is 127.1 mg / l, T 1/2 is increased to 4.5 hours. Cumulation with repeated administration is not observed.

Infectious-inflammatory diseases caused by sensitive microorganisms: respiratory tract infections (including pneumonia, lung abscess, pleural empyema);
complicated infections of the upper and lower parts of the urinary tract; gynecological infections (including adnexitis, endometritis, parametritis, pelvioperitonitis, abscess of the Douglas space, abscess of the Bartholin gland); infections of the skin and soft tissues; bacteremia, septicemia; infection in patients with neutropenia and immunosuppression.
Enter only in / in.

Dosage regimen is individual, depending on the severity of infection, the sensitivity of microorganisms, renal function.

For patients with normal renal function (CK> 50 ml / min) for severe infections, the single dose is 1 g, the daily dose is 2 g, the interval between administrations is 12 hours.

For patients with complicated, life-threatening infections, the single dose is 2 g, the daily dose is 4 g, the interval between administrations is 12 hours.

On the part of the digestive system: diarrhea, nausea, vomiting, pseudomembranous colitis, abdominal pain, constipation, taste change, increase in ALT, AST, APF, total bilirubin.

From the side of the central nervous system: dizziness, headache, confusion, insomnia, reversible encephalopathy.

From the cardiovascular system: violation of the heart rate.

From the side of the urinary system: interstitial nephritis, kidney failure.

From the coagulation system: increased prothrombin time or APTT, hemorrhage.

On the part of the hemopoietic system: eosinophilia, transient thrombocytopenia, transient leukopenia and neutropenia, anemia.

On the part of metabolism: a temporary increase in blood urea nitrogen and / or serum creatinine.

Allergic reactions: rash, itching, hives, anaphylactic reactions.

Local reactions: phlebitis, inflammation or pain at the injection site.

Hypersensitivity to penicillins, cephalosporin and other beta-lactam antibiotics.

Use in pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

Use with caution in patients with any form of allergy, especially with allergic reactions to drugs in history.
With the development of allergic reactions treatment should be discontinued.
With prolonged use of ceftirom, measures should be taken to prevent the development of dysbacteriosis, as well as monitor the picture of blood and kidney function.In the first weeks of treatment, the development of pseudomembranous colitis is possible.

With the simultaneous use of ceftirom with aminoglycosides, furosemide and other "loop" diuretics, nephro- and ototoxicity may be increased.

Probenecid slows down the excretion of ceftpirom from the body and, thereby, increases its concentration in the blood plasma.

With simultaneous administration of a solution of ceftirom with solutions of metronidazole, vancomycin, gentamicin, a pharmaceutical interaction is possible (each antibiotic should be administered separately).

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