Universal reference book for medicines

Active substance: chymotrypsin, trypsin

Type: Preparation with proteolytic activity

Manufacturer: SAMSON-MED (Russia)
Composition, form of production and packaging
Liofilizate for solution for local and external use
1 fl.

a mixture of chymotrypsin and trypsin 50 mg

Vials in volume of 5 ml (10) - packs cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2011.


Enzyme preparation of proteolytic action, cleaves necrotic tissue, without affecting the living tissue, due to the presence in it of specific anti- enzymes.
Liquefies viscous secrets and exudates.

Suppurative bronchopulmonary diseases:

- bronchoectatic disease;

- abscess of the lung;


- exudative pleurisy (for dilution of thick viscous sputum and sanitation of the respiratory tract).

Diseases of ENT organs:

- purulent sinusitis;

- purulent otitis (acute, subacute, chronic);

- eustachitis with viscous exudate;

- after tracheostomy to facilitate the removal of thick viscous exudate;

- chronic rhinitis.

In ophthalmology:

- diseases of the cornea (ulcer, herpetic keratitis);

- Burn of the mucous membrane of the eye;

- obstruction of tear ducts;

- Sluggish healing of the skin of the eyelids.

Burns, bedsores, trophic ulcers, purulent wounds (purging from purulent-necrotic masses, acceleration of healing).


In diseases of the respiratory system, the drug in a dose of 25-30 mg is dissolved in 5 ml of distilled water and injected into the respiratory tract through an inhalation device, a bronchoscope, an endotracheal probe, a tracheostomy tube.
The number of inhalations is from 1 to 3 times a day for several days, depending on the indications. Antibiotics, bronchodilators that enhance the action of chymopsin can be added to drug solutions.
With chronic rhinitis, the nasal cavity is dripped or sprinkled with a solution of Hymopsin 2-3 times a day (5 mg in 5 ml of 0.9% sodium chloride solution).
With chronic purulent otitis complicated with cholesteatoma, after washing with 0.9% sodium chloride solution, 0.5% solution of Himopsin (0.9% solution of sodium chloride) is instilled in the ear 2-3 times a day.
With thermal burns of the third degree, a thin layer of Himopsin is applied to the corpse at a rate of 1 g per 100 cm 2 of the wound surface and covered with a bandage soaked in a 0.9% solution of sodium chloride or 0.25% solution of procaine.
A moisture-proof bandage is applied on top to slow the drying of the dressings. The bandages are changed every other day.
When treating purulent wounds and bedsores, the drug is used in doses of 25-50 mg (in 10-50 ml 0.25% solution of procaine).
The solution is moistened with sterile gauze tampons, which are applied to the wound surface for a period of 2 hours to 24 hours, depending on the thickness of the purulent necrotic masses. Dressings with Hymopsin are changed every 3-5 days.
In the treatment of ulcers, corneal burns and keratitis, Hymopsin is applied in the form of eyebaths in a solution of 1: 500 daily for 2-3 days or as drops of 0.25% solution (prepared ex tempore) 4 times a day for 1-2 days to 2 drops.

To treat the obstruction of the lacrimal ducts and skin wounds of the eyelids, the drug is applied as a 1% solution (prepared ex tempore), by irrigation of the wound and washing of the lacrimal ducts.


There may be allergic reactions.

After inhalation: occasionally hoarseness, irritation of the mucous membrane of the respiratory tract, rapidly passing subfebrial temperature.

In ophthalmology: irritation and swelling of the conjunctiva can be noted;
in such cases it is recommended to reduce the concentration of the drug used.

- chronic heart failure of II-III degree;

- malignant neoplasms;

- emphysema of the lungs with respiratory failure;

- pulmonary tuberculosis (open form);

- Dystrophy and cirrhosis of the liver;

- Viral hepatitis;

- pancreatitis;

- hemorrhagic diathesis;

- hypersensitivity to chymopsin.

Do not enter into bleeding cavities, apply to ulcerated surfaces of malignant tumors.

With caution: the empyema of the pleura of tuberculosis etiology (resorption of exudate may contribute to the development of bronchopleural fistula).


Data on the use of the drug during pregnancy and during lactation are not present.


Contraindicated in dystrophy and cirrhosis of the liver, viral hepatitis.


Before applying the drug to people prone to allergic reactions, you should enter a single therapeutic dose of antihistamines (subcutaneously or intramuscularly).
In the next few hours after inhalations, the patient should carefully cough up phlegm or it should be removed by sucking.

Not described.


On prescription.


In a dry place, protected from light and out of reach of children, at a temperature not exceeding + 20 В° РЎ.
Shelf life - 3 years.
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