Universal reference book for medicines
Product name: FURAZOLIDONE (FURAZOLIDONE)

Active substance: furazolidone

Type: Antibacterial drug, nitrofuran derivative

Manufacturer: AVEKSIMA (Russia) manufactured by IRBITSK HFZ (Russia)
Composition, form of production and packaging
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Tablets are yellow or greenish-yellow, flat-cylindrical, with a facet.
1 tab.

furazolidone 50 mg

Auxiliary substances: potato starch - 20 mg, calcium stearate (calcium stearic acid) - 1 mg, sugar (sucrose) - 10 mg, tween 80 (polysorbate) - 0.2 mg, lactose (milk sugar) - 18.8 mg.

10 pieces.
- Packings without cell contour.
10 pieces.
- packings contour mesh (2) - packs cardboard.
10 pieces.
- Packings contour mesh (3) - packs cardboard.
10 pieces.
- packings contour mesh (4) - packs cardboard.
10 pieces.
- Packings contour mesh (5) - packs cardboard.
50 pcs.
- polymer cans (1) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2015.

PHARMACHOLOGIC EFFECT

Antimicrobial agent, derivative of nitrofurans.
It is active against Gram-positive and Gram-negative microbes, Trichomonas spp., Giardia lamblia. The most sensitive to furazolidone is Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Salmonella typhi, Salmonella paratyphi .
Slightly affects the pathogens of purulent and anaerobic infection.
Stability of microorganisms develops slowly. It blocks monoamine oxidase. Nitrofurans disrupt the processes of cellular respiration of microorganisms, inhibit the cycle of tricarboxylic acids (Krebs cycle), and also inhibit the biosynthesis of nucleic acids of microorganisms, as a result of which their shell or cytoplasmic membrane is destroyed. As a result of the action of nitrofurans, microorganisms produce fewer toxins, so that the improvement of the patient's general condition is possible even before the expressed suppression of microflora growth. Unlike many other antimicrobial drugs, they do not only depress, but even activate the body's immune system (increase the complement's titre and the ability of leukocytes to phagocytose microorganisms).
PHARMACOKINETICS

It is well absorbed by oral administration.
Against the background of inflammation of the meninges in the cerebrospinal fluid, concentrations equal to those in plasma are created. Rapidly and extensively metabolized mainly in the liver with the formation of a pharmacologically inactive metabolite (amino derivative). It is mainly excreted by the kidneys (65%), small amounts are found in the feces, where therapeutic concentrations are achieved against the causative agents of intestinal infections.
INDICATIONS

- dysentery;

- paratyphuses;

- giardiasis;

- food poisoning.

DOSING MODE

Inside, after eating.

With dysentery, paratyphoid and foodborne toxic infections - 100-150 mg 4 times / day (but not more than 800 mg), for 5-10 days.

With giardiasis : adults - 100 mg 4 times / day, children - 10 mg / kg / day, distributing the daily dose for 3-4 doses.

The highest single dose for adults is 200 mg;
daily - 800 mg.
SIDE EFFECT

Decreased appetite, right up to anorexia;
nausea, vomiting; Allergic reactions (skin rash, hyperemia and itching of the skin., angioedema).
With prolonged use - neuritis.

CONTRAINDICATIONS

- Pregnancy, lactation;

- increased individual sensitivity to the group of nitrofurans;

- terminal stage of chronic renal failure;

- deficiency of glucose-6-phosphate dehydrogenase;

- Children's age under 3 years (for this dosage form).

Carefully

Chronic renal failure, deficiency of glucose-6-phosphate dehydrogenase, diseases of the liver and nervous system.

APPLICATION FOR FUNCTIONS OF THE LIVER

The use of the drug in patients with terminal stage of chronic renal failure is contraindicated.

With caution, patients with chronic renal failure.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

With caution, patients with liver disease.

APPLICATION FOR CHILDREN

It is forbidden to use the drug for children under the age of 3 years (for this dosage form).

SPECIAL INSTRUCTIONS

Increases the sensitivity to the action of ethanol.

Medicines, alkalinizing urine, reduce the effect, and acidifying - increase.

Aminoglycosides and tetracycline increase antimicrobial properties.

During the treatment, precautions should be observed, as with monoamine oxidase inhibitors, namely: the exclusion from the diet of products containing tyramine: cheese, cream, beans, pickled herring, strong coffee.

For the prevention of neuritis with prolonged use it is necessary to combine with vitamins of group B.

OVERDOSE

Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).

Treatment: cancellation of drugs, taking a lot of fluids, symptomatic therapy, antihistamines, vitamin B vitamins.

DRUG INTERACTION

Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, and therefore, their simultaneous administration is not recommended.
Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephrine, tyramine can cause a sharp increase in blood pressure.
TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a dry place, protected from light and inaccessible to children.
Shelf life - 3 years.
Do not use after the expiration date.

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