Universal reference book for medicines
Name of the drug: FUZIDIN-NATRIUM (FUSIDIN-NATRIUM)

Active substance: fusidic acid

Type: Antibiotic

Manufacturer: BIOSINTEZ (Russia) BIOTEK group MFPPK (Russia)
Composition, form of production and packaging
The tablets covered with a cover
1 tab.

fusidine sodium salt 125 mg

- "250 mg

Auxiliary substances: PVP, magnesium stearate, sugar, milk, AFC, acidic red 2C, castor oil, titanium dioxide.

10 pieces.
- packings cellular planimetric (2) - packs cardboard.
20 pcs.
- banks of dark glass (1) - packs of cardboard.
20 pcs.
- polymer cans (1) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2005.

PHARMACHOLOGIC EFFECT

Antibacterial preparation.
Has a bacteriostatic effect.
It is active against Staphylococcus spp.
(Staphylococcus aureus, Staphylococcus epidermidis / including methicillin-resistant strains), Nocardia asteroides, Clostridia spp., Neisseria meningitidis, Neisseria gonorrhoeae.
The drug is moderately active against Streptococcus spp.
(including Streptococcus pneumoniae).
Staphylococci, resistant to penicillins, streptomycin, levomycetin and erythromycin, retain sensitivity to fusidin.

The preparation is resistant to Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Fungi, protozoa.

PHARMACOKINETICS

Suction and distribution

After ingestion, the drug is well absorbed and reaches high concentrations in the blood.

Fuzidine penetrates the skin, subcutaneous fat, lungs, liver, bones, pleural exudate, cartilaginous and connective tissue.
With prolonged use, cumulation is noted.
Excretion

It is excreted mostly with bile, to a lesser extent - with urine.

INDICATIONS

-septicemia;

-pneumonia;

-otitis;

-Abscesses;

-phlegmon;

-furunculosis;

-infected wounds and burns;

-infection of soft tissues;

-osteomyelitis;

-gonorrhea caused by strains resistant to benzylpenicillin, or with increased sensitivity of the patient to benzylpenicillin.

DOSING MODE

The drug is administered orally after a meal.

For adults, a single dose is 500 mg, a daily dose of 1.5 g (in 3 divided doses at 8-hour intervals).

In severe infections , the first 1-2 days 2-3 g / day, then the dose is reduced to 1.5 g / day.
The duration of the course of treatment is 7-14 days, with osteomyelitis 2-3 weeks.
For children, the drug is prescribed at the rate of 40-60 mg / kg of body weight / day, in severe infections - up to 80 mg / kg / day.

SIDE EFFECT

On the part of the digestive system: abdominal pain, nausea, vomiting, diarrhea.

Allergic reactions: hyperemia of the mucous membrane of the mouth and pharynx, pain when swallowing, skin rash.

CONTRAINDICATIONS

-increased sensitivity to the components of the drug.

PREGNANCY AND LACTATION

Fusidin sodium salt displaces bilirubin from the connection with plasma proteins, thereby increasing the risk of developing nuclear jaundice in newborns.
Therefore, when it is necessary to prescribe the drug Fusidine-sodium in pregnancy, it is necessary to evaluate the prospective benefit for the mother and the potential risk to the fetus.
APPLICATION FOR CHILDREN

For children, the drug is prescribed at the rate of 40-60 mg / kg of body weight / day, in severe infections - up to 80 mg / kg / day.

SPECIAL INSTRUCTIONS

It should be borne in mind that the side effect of the digestive system is due to the irritant effect of the drug on the gastrointestinal mucosa.
Therefore, it is recommended to take Fuzidine-sodium after meals, with milk or liquid food.
When developing allergic reactions, the drug should be discarded and desensitizing therapy should be prescribed.

In severe disease and the need for long-term use of the drug, it is recommended to combine Fusidine-sodium with semisynthetic penicillins or tetracyclines, which increases the effectiveness of therapy and prevents the emergence of resistant microorganisms.

OVERDOSE

At present, cases of an overdose of the drug Fusidine-sodium have not been reported.

DRUG INTERACTION

When Fusidine-sodium is combined with other antibacterial drugs, there is an increased antimicrobial effect.

TERMS AND CONDITIONS OF STORAGE

List B. The drug should be stored in a dry, dark place at room temperature.
Shelf life - 2 years.
Conditions of leave from pharmacies

The drug is released by prescription.

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