Universal reference book for medicines
Product name: PHTHALAZOL

Active substance: phthalylsulfathiazole

Type: Antibacterial sulfanilamide preparation

Manufacturer: BIOSINTEZ (Russia) BIOTEK group MFPPK (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Antibacterial agent, a sulfonamide derivative.
Has a wide spectrum of antimicrobial action. Phthalylsulfatiazole is active against gram-positive and gram-negative microorganisms, including. causative agents of intestinal infections. Poorly absorbed from the digestive tract. Acts mainly in the lumen of the intestine, where there is a gradual release of the sulfonamide part of the molecule.
The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, which leads to a disruption in the synthesis of tetrahydrofolic acid necessary for the synthesis of purines and pyrimidines.

INDICATIONS
Dysentery (acute and chronic in the acute stage), colitis, gastroenteritis;
prevention of infectious complications in surgical interventions on the intestine.
DOSING MODE
Adults - 1-2 g every 4-6 hours for 5-7 days.
Higher doses for adults inside: single dose - 2 g, daily - 7 g. Children under 3 years - 200 mg / kg / day in 3 doses for 7 days. Children older than 3 years - 400-750 mg (depending on age) 4 times / day.
SIDE EFFECT
Allergic reactions are possible.

CONTRAINDICATIONS
Hypersensitivity to phthalylsulfatiazole.

APPLICATION FOR CHILDREN
The application is possible according to the dosing regimen.

SPECIAL INSTRUCTIONS
If necessary, phthalylsulfatiazole is combined with sulfonamides or antibiotics that are well absorbed from the digestive tract.

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