Universal reference book for medicines
Name of the preparation: FLUSTOP (FLUSTOP)

Active substance: comb.
drug
Type: The drug for symptomatic therapy of acute respiratory diseases

Manufacturer: BIODEAL Laboratories (India)
Typical clinico-pharmacological article
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Combined drug, has antipyretic, analgesic, alpha-adrenostimulating, vasoconstrictive and antihistamine action, eliminates the symptoms of colds.

Caffeine stimulates the psychomotor centers of the brain, increases the effect of analgesics, removes drowsiness and fatigue, increases physical and mental performance, shortens the reaction time, temporarily reduces fatigue and drowsiness.

Paracetamol is a non-narcotic analgesic;
blocks COX, mainly in the central nervous system, affecting the centers of pain and thermoregulation; has analgesic and antipyretic effect.
Phenylephrine is an alpha-adrenomimetic with a moderate vasoconstrictor effect.

Chlorphenamine is a blocker of H 1 -gistamine receptors.
Narrows the vessels of the nose, eliminates swelling and flushing of the mucous membrane of the nasal cavity, nasopharynx and paranasal sinuses; reduces exudative manifestations, suppresses the symptoms of allergic rhinitis.
INDICATIONS
- febrile syndrome with colds and infectious diseases;

- sinusitis;

- Rhinorrhea (acute rhinitis, allergic rhinitis).

DOSING MODE
Inside, adults - 1-2 tab.
with an interval of 4-6 hours. The maximum daily dose is 12 tablets.
Children over 6 years - 1 tab.
with an interval of 4 hours; the maximum daily dose is 5 tab. within no more than 7 days.
SIDE EFFECT
Allergic reactions (skin rash, itching, hives, angioedema), nausea, epigastric pain;
anemia, thrombocytopenia, agranulocytosis. Increased excitability, dizziness, increased blood pressure, violation of falling asleep. Midriaz, paresis of accommodation, increased intraocular pressure, dryness of the oral mucosa; retention of urine.
With prolonged use in large doses: hepatotoxic effect, hemolytic or aplastic anemia, methemoglobinemia, pancytopenia;
nephrotoxicity (renal colic, glucosuria, interstitial nephritis, papillary necrosis).
CONTRAINDICATIONS
hypersensitivity;

- pronounced atherosclerosis of the coronary arteries;

- Arterial hypertension (severe course);

- diabetes mellitus (severe course);

- Pregnancy;

- lactation period;

- Children's age (up to 6 years).

With caution: deficiency of glucose-6-phosphate dehydrogenase;
hepatic and / or renal failure, angle-closure glaucoma, prostatic hyperplasia; congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome), arterial hypertension, thyrotoxicosis, diabetes mellitus, COPD (emphysema, chronic bronchitis), simultaneous administration of MAO inhibitors and beta-blockers.
PREGNANCY AND LACTATION
Contraindications: pregnancy;
lactation period.
APPLICATION FOR FUNCTIONS OF THE LIVER
C with caution: kidney failure.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
C with caution: hepatic insufficiency.

APPLICATION FOR CHILDREN
Contraindication - children's age (up to 6 years).

Children over 6 years - 1 tab.
with an interval of 4 hours; the maximum daily dose is 5 tab. within no more than 7 days.
SPECIAL INSTRUCTIONS
During the treatment period, the parameters of the peripheral blood and the functional state of the liver are monitored.

During the period of treatment, sleeping pills and anxiolytic drugs (tranquilizers) should not be taken.

Do not take with other drugs containing paracetamol.

If the symptoms do not go away within 5 days, you should consult your doctor.

During the treatment it is necessary to refrain from using ethanol (it is possible to develop a hepatotoxic effect).

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, it is necessary to refrain from driving vehicles and practicing other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

OVERDOSE
Symptoms: paracetamol (with the intake of more than 10-15 g) - pallor of the skin, decreased appetite, nausea, vomiting, toxic hepatitis, until the development of hepatonecrosis, increased activity of hepatic transaminases, increased prothrombin time.

Treatment: symptomatic, gastric lavage, administration of donors of SH-groups and precursors of glutathione-methionine synthesis 8-9 hours after overdose and acetylcysteine ​​- after 12 hours.

DRUG INTERACTION
Strengthens the effects of MAO inhibitors, sedatives, ethanol.

Ethanol enhances the sedative effect of antihistamines.

Antidepressants, antiparkinsonian and antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation.

SCS increases the risk of developing glaucoma.

Paracetamol reduces the effectiveness of uricosuric medicines.

Chlorphenamine simultaneously with MAO inhibitors, furazolidone can lead to hypertensive crisis, agitation, hyperpyrexia.

Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine.

The simultaneous administration of halothane increases the risk of ventricular arrhythmia.

Reduces the hypotensive effect of guanethidine, which in turn increases the alpha-adrenostimulating activity of phenylephrine.

TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE
Store in a dry place, protected from light, out of reach of children, at a temperature not exceeding 25 ° C.

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