Universal reference book for medicines
Product name: FOLACIN (FOLACIN)

Active substance: folic acid

Type: Vitamin preparation

Manufacturer: JADRAN Galenski Laboratorij (Croatia)
Composition, form of production and packaging
Tablets are flat-cylindrical, yellow in color with a slight marbling, orange inclusions are allowed, with a facet and a risk on one side, odorless.
1 tab.

folic acid 5 mg

Excipients: lactose monohydrate, povidone, crospovidone, microcrystalline cellulose, magnesium stearate.

10 pieces.
- blisters (1) - packs of cardboard.
10 pieces.
- blisters (2) - packs of cardboard.
10 pieces.
- blisters (3) - packs of cardboard.

Description of the drug approved by the manufacturer for the printed edition of 2015.


Vitamin preparation.
Folic acid in the body is converted into tetrahydrofolic acid, as a coenzyme, involved in various metabolic processes, and necessary for the normal maturation of megaloblasts and the formation of normoblasts. With a deficiency of folic acid, a megaloblastic type of hematopoiesis develops. The drug stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, in the exchange of choline, histidine. When pregnancy performs a protective function in relation to the action of teratogenic and damaging factors. Promotes normal maturation and functioning of the placenta.


After ingestion, folic acid, connecting in the stomach with the internal Factor factor (specific glycoprotein), is well and completely absorbed into the digestive tract.With MAX in the blood is reached after 30-60 minutes.

Distribution and Metabolism

Almost completely binds to plasma proteins.
It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of the enzyme dihydrofolate reductase). Penetrates through the BBB and the placenta, excreted in breast milk.

It is excreted by the kidneys as if unchanged (if the dose taken is much higher than the daily requirement), and in the form of metabolites.
It is excreted by hemodialysis. 5 mg of ingested folic acid is excreted from the body after 5 hours.

- Treatment and prevention of folic acid deficiency in the background of unbalanced or malnutrition;

- treatment and prevention of anemia in the presence of folic acid deficiency (macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, post-resection anemia, sideroblastic anemia in elderly patients, anemia associated with small bowel disease, sprue and syndrome malabsorption);

- treatment and prevention of anemia in pregnancy and lactation (breastfeeding);

- during pregnancy to prevent the development of neural tube defects in the fetus;

- long-term treatment with folic acid antagonists (methotrexate, sulfamethoxazole / trimethoprim combination), anticonvulsants (phenytoin, primidon, phenobarbital).


The drug is prescribed inside.

For treatment of megaloblastic anemia, caused by a deficiency of folic acid, appoint 5 mg / day for 4 months, for prophylaxis - 2.5 mg / day.

For the prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel diseases and unbalanced or malnutrition - 15 mg / day, patients with spruce disease - 5-15 mg / day.

To prevent the development of fetal neural tube defects - 2.5 mg / day for 4 weeks before the expected pregnancy.
Admission is continued during the first trimester of pregnancy.
Higher maintenance doses may be given to patients with alcoholism, as well as to patients with chronic infections and taking anticonvulsants.


From the digestive system: anorexia, nausea, bloating, bitterness in the mouth.

Allergic reactions: skin rashes, itching, erythema, bronchospasm.


- pernicious anemia;

- malignant neoplasms;

- deficiency of cobalamin;

- Hypersensitivity to the components of the drug.


The drug is used on indications during pregnancy and lactation (breastfeeding).


Patients on hemodialysis need elevated amounts of folic acid.

With prolonged use of folic acid, especially in high doses, it is possible to reduce the concentration in the blood of vitamin B 12 (cyanocobalamin).

Long-term use of the drug is recommended to combine with the intake of vitamin B 12 (cyanocobalamin).


Data on the overdose of Folacin are not provided.


At simultaneous application with chloramphenicol, neomycin, polymyxins, tetracyclines, absorption of folic acid decreases.

With the simultaneous use of folic acid reduces the effects of oral contraceptives, ethanol, sulfasalazine, cycloserine, glutetimide, methotrexate, phenytoin, primidin, chloramphenicol.

The use of folic acid can lower the plasma level of phenobarbital, phenytoin or primidon and cause an epileptic fit.

Reduction or change in absorption may occur with the simultaneous use of colestyramine and folic acid, therefore, folic acid should be taken 1 hour before or 4-6 hours after the administration of colestyramine.


The drug is approved for use as a means of OTC.


The drug should be stored out of reach of children at a temperature of no higher than 25 ° C.
Shelf life - 5 years.
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