Universal reference book for medicines
Name of the preparation: FENISTIL ® PENCIVIR (FENISTIL ® PENCIVIR)

Active substance: penciclovir

Type: Antiviral drug for external use

Manufacturer: NOVARTIS CONSUMER HEALTH (Switzerland) manufactured by NOVARTIS PHARMA PRODUCTIONS (Germany)
Composition, form of production and packaging
Cream for external use 1% homogeneous, white.
1 g

penciclovir 10 mg

Excipients: cetomacrogol 1000-9.4 mg, cetostearyl alcohol 77.2 mg, paraffin white soft 148.5 mg, liquid paraffin liquid 59.4 mg, propylene glycol 416.8 mg, purified water 278.7 mg.

2 g - aluminum tubes (1) - cardboard packs.

2 g - aluminum tubes (1) - plastic pencils complete with a mirror and applicators (20 pcs.).

5 g - aluminum tubes (1) - cardboard packs.

5 g - aluminum tubes (1) - plastic pencils complete with a mirror and applicators (20 pcs.).

Cream for external use (with toning effect) 1% homogeneous, from beige to brown.
1 g

penciclovir 10 mg

Auxiliary substances: cetomacrogol 1000 - 9.4 mg, cetostearyl alcohol - 77.2 mg, paraffin white soft - 148.5 mg, paraffin oil - 59.4 mg, propylene glycol - 415.55 mg, purified water - 277.45 mg, iron dye oxide red - 1.7 mg , iron oxide dye yellow oxide - 0.8 mg.

2 g - aluminum tubes (1) - cardboard packs.

5 g - aluminum tubes (1) - cardboard packs.


Description of the drug approved by the manufacturer for the printed edition of 2014.


Antiviral drug for external use.
Penciclovir is an antiviral drug that is active against Herpes simplex viruses of type 1 and type 2, the Varicella zoster virus. The virus can be inactive in the body for an extended period of time. At the time of activation (for example, due to fatigue, colds, flu), the virus begins to multiply, which leads to the development of fever in the form of bubble rashes, especially often on the lips or in areas around them. Penciclovir blocks the virus and stops its reproduction.The use of the drug leads to a faster recovery, a decrease in the intensity of pain, the period of risk of transmission of a viral infection is reduced.

With external application, the preparation is practically not subjected to systemic absorption.
Modern analytical methods can not detect penciclovir in the blood or urine of healthy volunteers after applying Fenistil ® Pencivir cream in doses many times higher than therapeutic.
Penetrating into the cells infected with the virus, penciclovir quickly passes into penciclovir triphosphate, which has pharmacological activity and persists in the affected cells for 12 hours.


- recurrent herpes simplex with localization on the lips (herpes labialis).


The drug is used externally.

Adults and children aged 12 years and older : a small amount of cream is squeezed onto the tip of the finger and applied to the affected area every 2 hours (approximately 8 times / day).
The course of therapy is conducted for 4 days.
The cream can also be applied with a cotton swab or a disposable applicator (for packages containing applicators).

The cream for external use with toning effect has masking properties, it masks the areas affected by herpes on the lips and on the skin around the mouth.


Local reactions: burning, tingling or numbness is possible immediately after applying the drug.


- children's age till 12 years;

- hypersensitivity to penciclovir, famciclovir or to other components of the drug.


Application during pregnancy and during breastfeeding is possible on strict indications in cases when the expected benefit for the mother exceeds the possible risk for the fetus or infant.


Contraindicated: children under 12 years.


Wash hands thoroughly before and after applying the cream.

Treatment should be started as early as possible, with the first signs of infection.
However, even with the development of herpes in the bubble stage, the use of Fenistil® Pencivir cream reduces the healing time (heals the affected areas, reduces pain and shortens the duration of the peeling of the crust from the virus).
In patients with weakened immunities or if the manifestations of the disease are vague, the doctor decides to apply the drug individually.

The drug should be used only on areas affected by herpes on the lips and on the skin around the mouth.
It is not recommended to apply the cream to the mucous membrane of the mouth, nose, or in the eyes and genital area.
It is necessary to conduct a full course of therapy with Fenistil ® Pencivir cream for 4 days, in order to achieve the greatest effect from the therapy, even if the signs of infection disappear after one or two days of treatment.

If the condition worsens or if there is no improvement after 4 days of therapy, the patient should consult a doctor

Impact on the ability to drive vehicles and manage mechanisms

Does not affect.


No cases of drug overdose have been reported.


Any drug interactions for the cream Fenistil ® Pencivir are not known.


The drug is approved for use as a means of OTC.


The drug should be stored out of reach of children at a temperature of no higher than 30 ° C;
Do not freeze. Shelf life - 3 years.
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