Universal reference book for medicines
Name of the preparation: TIAPRIDE

Active substance: tiapride

Type: Antipsychotic drug (antipsychotic)

Manufacturer: ORGANICA (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

Antipsychotic agent (antipsychotic) from the group of substituted benzamides.
Antipsychotic effect is due to blockade of dopamine D 2 receptors of the mesolimbic or mesocortical system. Has analgesic effect with interoceptive and exteroceptive pain. Has a sedative effect due to blockade of adrenoreceptors of the reticular formation of the brainstem; antiemetic effect associated with blockade of dopamine D 2 receptors in the trigger zone of the vomiting center; hypothermic action due to blockade of dopamine receptors of the hypothalamus.
After oral administration, it is rapidly absorbed from the digestive tract.
C max in blood plasma is achieved after 1 h. Binding to plasma proteins is low. Penetrates through the BBB. T 1/2 is 3-4 hours. It is excreted by the kidneys mainly unchanged.
With renal failure, the release of thiaprid from the body slows down.

Agitation, aggression, especially with chronic alcoholism, in the elderly;
resistant to therapy, severe pain syndrome; chorea, tics in Tourette's disease, severe behavioral disorders, accompanied by aggression and agitation.
Individual, depending on the indication, the age of the patient and the dosage form used.

From the side of the central nervous system: drowsiness, sleep disturbances, agitation, indifference, dizziness, headaches, parkinsonism syndrome;
rarely - spastic torticollis, oculogic crises, akathisia, tardive dyskinesia; in some cases - ZNS.
On the part of the endocrine system: rarely - symptoms caused by hyperprolactinemia (amenorrhea, galactorrhea, breast enlargement, breast pain, impotence, impaired orgasm.

From the cardiovascular system: increased interval QT, orthostatic hypotension;
in some cases - arrhythmias of the "pirouette" type.
Presence or suspicion of prolactin-dependent tumors, pheochromocytoma;
increased sensitivity to tiapridu.
In pregnancy, tiaprid is used only in absolute indications in minimum effective doses.
Newborns, whose mothers received tiaprid during pregnancy, it is recommended to monitor the functions of the central nervous system and digestive tract.
It is not known whether thiaprid is excreted in breast milk.
If it is necessary to use lactation, breastfeeding should be discontinued.
Use with caution in renal failure.

Use with caution in elderly patients.

With extreme caution apply in patients with epilepsy because of the possible lowering of the threshold of convulsive readiness.

Use with caution in severe cardiovascular diseases, parkinsonism, renal insufficiency, as well as in elderly patients.

Parenteral administration is performed under the supervision of a physician.

During the treatment with thiapride, levodopa, dopamine receptor agonists (amantadine, apomorphine, bromocriptine, cabergoline, entacapone, lizard, pergolide, pyribedil, pramipexole, quinagolide), sultopride should not be used;
drugs that can cause arrhythmias of the type "pirouette" (antiarrhythmics of IA and III classes, chlorpromazine, levomepromazine, thioridazine, trifluoperazine, sultopride, droperidol, haloperidol, pimozide, bepridil, cisapride, difemanyl, erythromycin for IV administration, vinokamine for / in the administration, as well as halofantrine, morphloxacin, pentamidine, sparfloxacin).
Do not drink alcohol.

Impact on the ability to drive vehicles and manage mechanisms

They are used with caution in patients whose activity requires concentration of attention and a high rate of psychomotor reactions.

With the simultaneous use of drugs that depress the central nervous system (including opioid analgesics, antihistamines, barbiturates, benzodiazepines), it is possible to increase the oppressive effect on the central nervous system.

With the simultaneous use of antihypertensive agents, it is possible to intensify the hypotensive effect.

[MSK] 01.04 in the RK is not registered.

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