Universal reference book for medicines

Active substance: nonappropriate

Type: Preparation with proteolytic activity for external use

Manufacturer: СПбН��ВС ФМБА (Russia)
Composition, form of production and packaging
Liofilizate for the preparation of a solution for intracavitary and external use
in the form of a porous mass or white or white powder with a yellowish hue.

1 amp.

protease (from the culture of Aspergillus terricola) 100 PES

100 PE - ampoules (10) - packs of cardboard.

Liofilizate for the preparation of a solution for intracavitary and external use in the form of a porous mass or white or white powder with a yellowish hue.

1 f.

protease (from the culture of Aspergillus terricola) 100 PES

100 PE - bottles (10) - packs of cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2013.


Terrideca is a proteolytic enzyme obtained by the covalent attachment of terrylitin to oxidized polyglucin.

Terrylitin is a microbial proteolytic enzyme derived from native solutions of the Aspergillus terricola culture strain H-20, which has a broad spectrum of specific hydrolytic activity against various protein substrates, used as a necrolytic and wound healing agent for external use.

The addition of polyglukine to terrylitin significantly reduced the allergic and locally irritating effect of the drug.

The main mechanism of action is due to the proteolytic activity of terrylitin and its ability to hydrolyze various protein substrates, including mucins, and also to exert fibrinolytic action.


Pharmacokinetics for this drug has not been studied.


- purulent wounds;

- pressure sores;

- trophic ulcers;

- abscesses of subcutaneous tissue of different localization (after opening, removal of non-viable tissues, thorough drainage of the abscess cavity);

- empyema of the pleura;

- coagulated hematorax;

- purulent tracheobronchitis;

- bronchoectatic disease;

- stasis of sputum after resection of the lungs.


Terridecase is used in the form of a solution, for which the contents of the vial (ampoule) 100 PE (Proteolytic Units) are dissolved in 2-5 ml of distilled water or 0.9% solution of sodium chloride, or 0.25% proline solution.

Apply externally, intrapleural, vitritrragheal, intrabronchial.

On purulent wounds, pressure sores, trophic ulcers impose napkins, moistened with a solution of Terridekazy, a waterproof bandage is applied from above;
the dressing is changed once a day or every other day.
With open sanation of the empyema of the pleura in the pleural cavity, injections of turuns with the drug are introduced.

With closed puncture sanation, a solution of Terridecase in a dose of 100 PE is administered intrapleural both in the preoperative and postoperative periods once a day.
The course of treatment is 2-7 procedures.
With the closed puncture treatment of postoperative hematorax, the solution of Terridecase is administered intrapleural at a dose of 100-200 PE per day with courses from 3-7 injections with aspiration of liquefied exudate (2-3 hours after the enzyme administration).

With a purulent tracheobronch , 3-5 ml of a solution of Terridecase (100 PU) is administered through the intubation tube (or intra-tracheal) 5-6 times a day for 3-4 days.

At a delay of a sputum in the postoperative period after a resection of lungs intra-bronchial 2-3 ml of a solution of Terridecase (10-15 PE) are injected, For which 100 PU of a drug are dissolved in 20 ml of 0.9% sodium chloride solution.

The course of treatment is 1 -3 procedures.


The rise in body temperature is due to the absorption of products of proteolysis of viable tissues with insufficient drainage of the wound, allergic reactions.


bleeding wounds;

bleeding ulcers;

- Ulcerated surfaces of malignant tumors;

- simultaneous reception of thrombolytic drugs in order to avoid hemorrhagic complications;

- do not enter inflammation in the foci (before autopsy);

- Pregnancy, lactation;

- children's age till 18 years;

- Individual intolerance.


The safety of taking the drug during pregnancy and during lactation with external and intracavitary application has not been studied.


Due to the lack of data on the use of the drug in children under 18 years of age (efficacy and safety of the drug is not established), do not prescribe the drug without consulting a doctor.


Do not use intravenously.

In case of complications, you should create conditions for a good outflow of pus from the wound, or cancel the drug.

Impact on the ability to drive vehicles and manage mechanisms

On the adverse impact on the ability to drive vehicles and management mechanisms have not been reported.


Cases of an overdose have not been revealed.


Terridecase promotes better penetration into the inflammatory focus of other drugs (hydroxymethylquinoxaline dioxide, ampicillin + oxacillin, lincomycin).

The drug is compatible with antimicrobial and chemotherapeutic agents.


On prescription.


At temperatures from 0 to 10 В° C in a dry, dark place.
Keep out of the reach of children. Shelf life - 3 years.
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