Universal reference book for medicines
Name of the preparation: THERAFLU В® LAR (THERAFLU В® LAR)

Active substance: benzoxonium chloride, lidocaine

Type: The drug with antimicrobial and local anesthetic action for topical application in ENT practice and dentistry

Manufacturer: GlaxoSmithKline Helsker (Russia) manufactured by NOVARTIS CONSUMER HEALTH (Switzerland)
Composition, form of production and packaging

Spray for topical application in the form of a clear, colorless solution with the smell of mint.
100 ml

benzoxonium chloride 0.2%

lidocaine hydrochloride 0.15%

[PRING] ethanol 96% (v / v) - 10%, glycerol 15%, hydrochloric acid 0.1N - 0.0581%, peppermint oil 0.01%, menthol 0.0025%, purified water 100%.

30 ml - bottles of high-density polyethylene (1) complete with a spraying device - packs of cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2014.


Combined for topical use, contains antiseptic and local anesthetic.

Benzoxonium chloride - quaternary ammonium salt: N-benzyl N-dodecyl N, N-di (2-hydroxyethyl) ammonium chloride.
Due to the cationic structure it possesses membrane-active activity and has a pronounced antibacterial effect on gram-positive and, to a lesser extent, gram-negative microorganisms. It also has antifungal and antiviral activity against membrane viruses (including influenza, parainfluenza and herpes viruses).
Lidocaine is a local anesthetic that, in inflammatory processes, reduces the pain in the throat when swallowing.


Benzoxonium chloride is practically not absorbed.
The concentration of benzoxonium chloride is practically not determined. In the tissues of the body, the accumulation of the active substance was not detected. About 1% of the received dose of benzoxonium chloride is found in urine.
Lidocaine is absorbed when ingested and through the oral mucosa.
Metabolized by the "first pass" through the liver. When administered orally, the bioavailability is about 35%. Metabolites of lidocaine are excreted together with urine, less than 10% of the active substance is excreted unchanged.

Infectious-inflammatory diseases of the oral cavity and pharynx:


- laryngitis;

- Catarrhal angina;

- stomatitis;

ulcerative gingivitis;

- chronic tonsillitis (as an auxiliary).


Adults appoint 4 sprays (approximately 0.5 ml) 3-6 times / day.

Children aged 4 years and older are prescribed no more than 2-3 sprays 3-6 times / day.

Duration of treatment - no more than 5 days.
If there is no relief of symptoms within 5 days of therapy, the patient should consult a doctor.
Spray is sprayed in the mouth, holding the can upright.


Determination of the frequency of adverse reactions: very often (? 10%);
often (? 1%, but? 10%), infrequently (? 0.1%, but? 1%), rarely (≥0.01%, ≥ 0.1%), very rarely (≥0.01%).
Local reactions: infrequently - irritation, which is temporary.
When using the drug for more than 2 weeks, a reversible brown color of the tongue or teeth can be observed.
Allergic reactions: in isolated cases - hives, swelling of the face, swelling of the larynx.


- Pregnancy;

- the period of lactation (breastfeeding);

- Children's age up to 4 years;

- hypersensitivity to the components of the drug;

- Hypersensitivity to ammonia compounds.


TeraFlu В® LAR is contraindicated in pregnancy and lactation (breastfeeding).

The clinical experience of the drug during pregnancy is very limited.

There are no clinical data on the release of active substances with breast milk.

In experimental studies , the effect of the drug on reproductive function and fetal development was not found.


Contraindicated: children under 4 years.


When using TeraFlu В® LAR, alcohol should be avoided.

Impact on the ability to drive vehicles and manage mechanisms

Does not affect.


Symptoms: when you accidentally take the drug (as well as other ammonium compounds) in high doses, nausea and vomiting are possible.
The content of lidocaine in the preparation is insignificant and can not cause serious symptoms of an overdose.
Treatment: it is recommended to drink milk or eat egg whites, whipped in water.


The effectiveness of benzoxonium chloride decreases with simultaneous use of anionic-active agents, for example, toothpaste.

Ethanol increases the absorption of benzoxonium chloride.


The drug is approved for use as a means of OTC.


The drug should be stored out of reach of children at a temperature of no higher than 30 В° C.
Shelf life - 5 years.
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