Universal reference book for medicines

Active substance: dextran

Type: Plasma Substitute

Manufacturer: КРАСФАРМА (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

Solutions of high-molecular dextran with sodium chloride, glucose or mannitol, are polyfunctional plasma-substituting solutions.
Normalize hemodynamics, increase the volume of fluid in the bloodstream. Solutions of low-molecular dextran, in addition, contribute to improving microcirculation, reduce the aggregation of blood cells, the viscosity of the blood. Dextran solutions containing mannitol also have an osmo-diuretic effect.
Solutions of high molecular weight dextran: pronounced posthemorrhagic hypovolemia, hypovolemic shock due to trauma, blood loss during childbirth, as a result of ectopic pregnancy, etc.
Hypovolemia due to loss of plasma (burns, compression syndrome). Preoperative and postoperative prevention of embolism.
Solutions of low-molecular dextran: microcirculation disorders, traumatic shock, burn shock, compression syndrome.
Septic shock. Substitution of plasma volume for blood loss in pediatrics. To fill the apparatus of artificial circulation (in certain proportions with blood).
Dextran with a molecular weight of 1000: prevention of severe allergic reactions to IV injection of dextran solutions.

Solutions of high molecular weight dextran are injected IV at a rate of 60-80 drops per minute in an amount of up to 2-2.5 liters (with significant blood loss - with additional blood administration).

Solutions of low molecular weight dextran when used as a blood substitute are usually administered in the same doses.
In other cases, the daily dose should not exceed 20 ml / kg. The rate of IV infusion is determined by the indications and severity of the patient's condition.
Dextran with a molecular weight of 1000 is administered intravenously to adults in a dose of 3 g (20 ml), children - at a dose of 45 mg / kg (0.3 ml / kg) - 1-2 minutes before / in infusion of a dextran solution.
The interval between the administration of dextran with a molecular weight of 1000 and the infusion of the dextran solution should not exceed 15 minutes. If more than 15 minutes have passed, dextran with a molecular weight of 1000 should be reintroduced. It can be administered before each infusion of dextran solution, especially if more than 48 hours have passed after the previous infusion.
Possible: allergic reactions.

Rare: arterial hypotension.

Trauma to the skull with increased intracranial pressure, cerebral hemorrhage and other cases where the introduction of large amounts of fluid is not indicated.Oliguria and anuria caused by organic kidney disease, heart failure, coagulation and hemostasis, a tendency to allergic reactions.
For solutions with glucose - diabetes mellitus and other disorders of carbohydrate metabolism.
Contraindicated in oliguria and anuria due to organic kidney disease.

In connection with possible allergic reactions, the first 10-20 ml of the infusion solution is recommended to be administered slowly, observing the patient's condition.Given the possibility of developing hypertension, it should be borne in mind that appropriate means for intensive care may be required.

Dextran with a molecular weight of 1000 can not be diluted or mixed with dextran solutions for infusions.
Dextran with a molecular weight of 1000 can be administered I / O through the Y-branch or the rubber tube of the infusion system, provided that during the injection there is no significant dilution of the drug.
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