Composition, form of production and packaging
Eye drops 1% in the form of a transparent, slightly colored liquid.
1 ml
proxodolol (butyl amino hydroxypropoxyphenoxymethyl methyl oxadiazole) 10 mg
Excipients: benzethonium chloride, sodium chloride, citric acid, sodium citrate, water, water.
5 ml - a bottle-droppers polymer (1) - packs cardboard.
5 ml - a bottle-droppers polymer (50) - packs cardboard.
10 ml - a bottle-droppers polymer (1) - packs cardboard.
10 ml - a bottle-droppers polymer (50) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2005.
PHARMACHOLOGIC EFFECT
Antiglaucoma preparation. Non-selective beta-blocker with alpha-adrenergic blocking activity. Affects ? 1 -,? 2 - and? -adrenoceptors.
Reduces intraocular pressure, which is due to a decrease in the production of aqueous humor.
The drug does not change the diameter of the pupil and the accommodation of the eye, it does not have a locally irritating effect.
The hypotensive effect of the drug with respect to intraocular pressure occurs 15-30 minutes after instillation, reaches a maximum after 4-6 hours.
PHARMACOKINETICS
Data on the pharmacokinetics of Proxodolol-AKOS are not available.
INDICATIONS
- increased intraocular pressure;
Open-angle glaucoma;
-Afakicheskaya glaucoma and other types of secondary glaucoma;
- as an additional means to reduce intraocular pressure in closed-angle glaucoma (in combination with miotics);
-conditioned glaucoma (with insufficient other therapeutic measures).
DOSING MODE
The drug should be instilled in the conjunctival sac of the affected eye 1 drop 2-3 times / day.
SIDE EFFECT
From the side of the organ of vision: blurred vision.
Allergic reactions: local or generalized exanthema, urticaria.
From the side of the central nervous system: dizziness, headache, weakness.
On the part of the digestive system: dry mouth, nausea, gastralgia.
From the cardiovascular system: bradycardia, AV blockade, lowering blood pressure.
Other: increased myometrium contractility, bronchospasm development.
CONTRAINDICATIONS
- bronchial asthma, chronic obstructive pulmonary diseases;
-chronic heart failure in the stage of decompensation;
- sinus bradycardia;
-AV blockade of II or III degree;
-Arterial hypotension;
-cardiogenic shock;
-insulin-dependent diabetes mellitus (type I);
-increased sensitivity to the components of the drug.
PREGNANCY AND LACTATION
There is no sufficient experience of using Proxodolol-AKOS during pregnancy and lactation.
The use of the drug is possible only if the intended use for the mother exceeds the possible risk to the fetus or baby.
APPLICATION FOR CHILDREN
Sufficient experience in the use of the drug in children there. The use of Proxodolol-AKOS is only possible if the intended benefit exceeds the risk of adverse reactions.
SPECIAL INSTRUCTIONS
During the application of Proxodolol-AKOS, it is not recommended to wear soft contact lenses.
When using hard lenses, remove them before instillation and re-put them 15-20 minutes after the instillation of the drug.
Use in Pediatrics
Sufficient experience in the use of the drug in children there. The use of Proxodolol-AKOS is only possible if the intended benefit exceeds the risk of adverse reactions.
Impact on the ability to drive vehicles and manage mechanisms
After instillation of the drug in some patients, blurred vision may be observed, therefore, for some time after instillation, one should not engage in activities requiring clarity of vision and speed of psychomotor reactions.
OVERDOSE
Currently, there is no data on drug overdose.
DRUG INTERACTION
Proxodolol-AKOS in a joint application potentiates the action of pilocarpine, clonidine.
With the simultaneous use of Proxodolol-AKOS with alpha and beta-adrenoblockers for oral administration, there is a mutual enhancement of their action.
TERMS AND CONDITIONS OF STORAGE
List B. The drug should be stored in a place protected from light, inaccessible to children. Shelf life - 2 years.
Conditions of leave from pharmacies
The drug is released by prescription.
