Universal reference book for medicines
Product name: PLE-SPA (PLE-SPA)

Active substance: drotaverine

Type: Myotropic antispasmodic

Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

Spasmolytic of myotropic action.
The chemical structure and pharmacological properties are close to papaverine, but it surpasses its effectiveness and duration of action. Reduces the tone of smooth muscles of internal organs, reduces their motor activity. Has a vasodilating effect.
After ingestion, drotaverin is rapidly absorbed from the digestive tract.
Bioavailability is about 100%. Does not penetrate the BBB.
Prevention and treatment of functional disorders and pain syndrome caused by spasm of smooth muscles (including spasms of the gastrointestinal tract, urinary tract associated with cholelithiasis, cholecystitis, peptic ulcer of the stomach, duodenal ulcer, spasm of the pyloric and cardiac part of the stomach, spastic constipation, spastic colitis proctitis, tenesmus, postoperative colic due to gas retention, in connection with nephrolithiasis, pyelitis);
when carrying out instrumental research;spasms of peripheral arteries, vessels of the brain; algodismenorea.
To reduce the excitability of the uterus during pregnancy;
with spasm of the uterus pharynx in childbirth, prolonged opening of throat, postnatal fights, threatening abortion.
Inside, in / m, in / in or n / to adults - 40-80 mg 1-3 times / day.
With hepatic and renal colic, it is recommended to inject iv slowly in a dose of 40-80 mg.
With spasms of peripheral arteries, drotaverin can be administered in / a.

For children under the age of 6 years with oral administration, a single dose is 10-20 mg, 6-12 years - 20 mg, frequency of application 1-2 times / day.

From the cardiovascular system: palpitation, a feeling of heat;
when in / in the introduction of cases of lowering blood pressure (up to the collapse), the development of AV-blockade, the appearance of arrhythmias.
On the part of the respiratory system: when in / in the introduction, cases of oppression of the respiratory center are noted.

Other: dizziness, increased sweating.

Severe renal failure, severe hepatic insufficiency, severe heart failure (low cardiac output syndrome), lactation (breastfeeding), childhood (for parenteral use), hypersensitivity to drotaverin.

Use with caution in pregnancy and lactation (breastfeeding).

For children under the age of 6 years with oral administration, a single dose is 10-20 mg, 6-12 years - 20 mg, frequency of application 1-2 times / day.

Caution is used in patients with severe arteriosclerosis of the coronary arteries, with arterial hypertension.

Drotaverine can be used as part of a combination therapy for the management of hypertensive crisis.

Use in Pediatrics

With caution, use drotaverin (for oral administration) in children.
Parenteral use in children is contraindicated.
With simultaneous use with tricyclic antidepressants, quinidine, procainamide, the decrease in blood pressure, caused by tricyclic antidepressants, quinidine and procainamide, intensifies.

With simultaneous use, the spasmogenic activity of morphine decreases.

With simultaneous application with levodopa, a decrease in the antiparkinsonian effect of levodopa is possible.

With simultaneous use, the effect of papaverine, bendazole and other antispasmodics (including m-holinoblokatorov) is intensified.

With simultaneous use with phenobarbital, the spasmolytic effect of drotaverin increases.

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