Composition, form of production and packaging
? Cream for external use 2% of white to light yellow color.
1 g
natamycin 20 mg
Excipients: cetyl ether wax, decyl oleate (cetyl V), sodium lauryl sulfate, propylene glycol, propyl parahydroxybenzoate, methyl parahydroxybenzoate, cetostearyl alcohol, purified water.
30 g - aluminum tubes (1) - cardboard packs.
30 g - plastic tubes (1) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2014.
PHARMACHOLOGIC EFFECT
Antifungal polyene antibiotic from the macrolide group, which has a wide spectrum of action. It has a fungicidal effect. Natamycin binds the sterols of the cell membrane of the fungal cell, disrupting its integrity and function, which leads to cell death.
Most pathogenic yeast fungi are sensitive to natamycin, especially Candida albicans.
Less sensitive to natamycin is dermatophytes.
Resistance to natamycin in clinical practice is not noted.
PHARMACOKINETICS
When applied to the skin and mucous membranes, practically does not undergo systemic absorption, so it does not have a systemic effect.
INDICATIONS
- fungal diseases of the skin and mucous membranes caused by susceptible pathogens (including vaginitis, vulvitis, vulvovaginitis, balanoposthitis caused by fungi of the genus Candida, candidiasis of skin and nails, external otitis, or primarily caused by fungi, or complicated by candidiasis, dermatomycosis ).
DOSING MODE
With dermatomycosis (including candidiasis of the skin, diaper rash in children), the cream is applied to the affected surface of the skin one or more (up to 4) times a day.
With mycosis of the external auditory canal, the affected surface is cream coated once or several times (up to 4 times) per day. Before using the drug, the ear is cleaned. After applying the drug in the ear canal, put a tampon made of natural material (cotton, wool).
With vulvitis, vulvovaginitis, balanoposthitis, the cream is applied to the affected areas of the skin once or several times a day.
The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease is recommended to continue treatment a few more days.
SIDE EFFECT
Local reactions: slight irritation, burning sensation.
CONTRAINDICATIONS
- Hypersensitivity to the components of the drug.
PREGNANCY AND LACTATION
Possible use of Pimafucin during pregnancy and lactation.
Data on adverse effects on the fetus are absent.
APPLICATION FOR CHILDREN
Cream Pimafucin В® can be given to children and newborns.
SPECIAL INSTRUCTIONS
In the case of a chronic or recurrent infection, local treatment may be supplemented with the administration of Pimafucine in the form of tablets.
Use in Pediatrics
Cream for external use Pimafucin В® can be given to newborns.
OVERDOSE
At present, no cases of an overdose of PimafucinВ® have been reported.
DRUG INTERACTION
The drug interaction of Pimafucin В® is not described.
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of reach of children at a temperature of 15 В° to 25 В° C. Shelf life - 4 years.
