Universal reference book for medicines
Name of the preparation: PICAMILON (PICAMILON)

Active substance: nicotinoyl gamma-aminobutyric acid

Type: Nootropic preparation

Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

Nootropic agent, dilates the vessels of the brain.
It also has a tranquilizing, psychostimulating, antiaggregant and antioxidant effect. Improves the functional state of the brain due to the normalization of tissue metabolism and effects on cerebral circulation (increases the volume and linear speed of cerebral blood flow, reduces the resistance of cerebral vessels, inhibits platelet aggregation, improves microcirculation).
At the course reception increases physical and mental efficiency, reduces headache, improves memory, normalizes sleep;
contributes to the reduction or disappearance of feelings of anxiety, tension, fear; improves the condition of patients with motor and speech disorders.
Absorption is fast and complete, regardless of the route of administration.
It penetrates through the BBB, and is retained for a long time in the tissues of the body.Bioavailability is 50-88%. It is excreted mainly by the kidneys in unchanged form. T 1/2 - 0.51 h.
Cerebrovascular insufficiency, asthenia, depressive disorders in old age.

Conditions, accompanied by anxiety, fear, increased irritability, emotional lability.
Asthenic conditions caused by various neuropsychic diseases.
As part of a comprehensive treatment - for the management of acute alcohol intoxication;
with chronic alcoholism - to reduce asthenic, asthenoneurotic, postpsychotic, pre-recurrent conditions, as well as alcoholic encephalopathy.
In the complex therapy - migraine (prevention), TBI, neuroinfection.

Improving the portability of physical and mental loads (to persons who are in tense and extreme conditions of activity, to restore the physical performance of athletes, to increase resistance to physical and mental stress).

Open angle glaucoma (to stabilize the visual function).

In urological practice (in children older than 3 years and in adults with disorders of urination) to improve the adaptive function of the bladder (reducing detoxification hypoxia).

Is taken orally, regardless of food intake.

In cerebrovascular diseases, a single dose of 20-50 mg 2-3 times / day, a daily dose of 60-150 mg.
The course of treatment - 1-2 months. Repeated course - after 5-6 months.
Depressive states of late age: 40-200 mg / day for 2-3 doses, the optimal dose range is 60-120 mg / day for 1.5-3 months.
As an anti-asthenic and anxiolytic agent - 40-80 mg / day, if necessary - up to 200-300 mg / day, for 1-1.5 months.
At an alcoholism during the period of an abstinence appoint in a dose of 100-150 mg / sut, a short course of 6-7 days;
with more persistent violations outside of abstinence - 40-60 mg / day for 4-5 weeks.
To restore efficiency and with increased loads - 60-80 mg / day for 1-1.5 months, for athletes in the same dose, for 2 weeks.
training period.
Parenterally enter into / in a drip or stream (slowly), in / m.

With chronic disorders of cerebral circulation - in / in or / m, 100-200 mg, 1-2 times / day, daily dose - 20-40 mg.
Depending on the condition of the patient used in the morning in / in the drip, in the evening - in / m; or for 10 days in / in, then in / m. The course of treatment is 15-30 days.
For the treatment of acute uncomplicated intoxication, ethanol in the complex therapy is administered at a saturating dose of 5 mg / kg and a maintenance dose of 1.56 mg / kg / h in a volume of 2.5 liters of the infusion solution, for 4 hours, in the morning and in the evening.

In asthenic conditions, depending on the severity of the disease, in addition to oral administration, I / m in a daily dose of 20-40 mg for 1 month

From the side of the central nervous system: irritability, agitation, anxiety, dizziness, headache.

Allergic reactions: skin rash, itching.

Other: nausea.

Chronic renal failure, pregnancy, lactation, hypersensitivity to nicotinoyl gamma-aminobutyric acid.

Contraindicated in pregnancy, during lactation (breastfeeding).

Contraindicated in chronic renal failure.

Reduces the duration of barbiturates.

Strengthens the action of narcotic analgesics.

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