Composition, form of production and packaging
Syrup of light orange color, transparent, with a fruity smell (tutti-frutti) and sweet taste.
1 ml
cyproheptadine hydrochloride sequihydrate 430 Ојg,
which corresponds to a content of cyproheptadine hydrochloride 400 Ојg
Excipients: ethanol 96%, sorbic acid, sucrose, sodium hydroxide, glacial acetic acid, tutti-frutti aromatic additive, ariavitum sunset yellow (dye sunset yellow CI15895 E.110), purified water.
100 ml - bottles of dark glass (1) complete with a dosing cap - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2005.
PHARMACHOLOGIC EFFECT
Cyproheptadine is an active antagonist of histamine, acetylcholine and serotonin. Peritol prevents development and facilitates the course of allergic reactions. In addition to antiallergic antipruritic, antiexudative, anticholinergic and sedative effects. The drug stimulates the appetite; blocks the hypersecretion of somatotropin in acromegaly and the secretion of ACTH in the Itenko-Cushing syndrome.
PHARMACOKINETICS
When applied inside quickly and well absorbed from the digestive tract. C max in the blood is reached within the first 2 hours; the therapeutic level of concentration persists for 4-6 hours. It is well distributed in the body, including the CNS. Penetration of the drug through the placental barrier and its excretion in breast milk is not confirmed.
Cyproheptadine is metabolized in the liver. After a single oral intake in a dose of 4 mg, 2-20% is excreted through the intestine, at least 40% of the administered dose of the drug is excreted in the urine, mainly in the form of conjugates with glucuronic acid. Elimination of the drug is reduced with renal failure.
INDICATIONS
- allergic diseases: urticaria, hay fever, serum sickness, angioedema Quincke;
- skin diseases: contact dermatitis and toxicodermia, neurodermatitis, eczema;
- headaches of vascular origin (migraine, histamine headache);
- Vasomotor rhinitis;
- Allergic reactions to taking medicines, blood transfusion, introduction of radiocontrast substances;
anorexia of various origins.
DOSING MODE
Taking into account the sedative effect, characteristic for the beginning of treatment, the first dose of Peritol is recommended to be taken after supper.
Children aged 6 to 24 months Peritol prescribed in a dose of 0.4 mg / kg of body weight per day.
For children aged 2 to 6 years, the daily dose is 6 mg / day (3 times 5 ml of syrup), the maximum daily dose of 8 mg.
Children suffering from anorexia are prescribed from 6-8 mg / day.
For children aged 7 to 14 years, Peritol is prescribed in a dose of 12 mg / day (3 times / day for 10 ml of syrup).
For adults, the usual daily dose of Peritol for adults is 12 mg (3 times / day for 10 ml of syrup).
The maximum daily intake for adults can be 32 mg (80 ml of syrup).
For the treatment of chronic urticaria prescribe 6 mg / day (5 ml of syrup 3 times / day).
For treatment of anorexia Peritolum appoint 12 mg / day (10 ml of syrup 3 times / day).
When an attack of acute migraine is recommended, take 4 mg of Peritol once (10 ml of syrup), in the absence of effect, repeat the same dose after 30 minutes, but for 4-6 hours the dose should not exceed 8 mg (20 ml of syrup).
For maintenance therapy, usually prescribed 4 mg (10 ml of syrup) 3 times / day.
The dose of Peritol for the treatment of patients with impaired liver function should be reduced.
For elderly patients during treatment with Peritol it is recommended to conduct systematic observation.
SIDE EFFECT
From the side of the central nervous system: drowsiness, dizziness, headache, anxiety, tremor, ataxia, visual hallucinations.
From the gastrointestinal tract: dry mouth, nausea, vomiting, diarrhea.
From the cardiovascular system: hypotension, tachycardia.
From the hemopoietic system: hemolytic anemia, leukopenia, agranulocytosis.
Allergic reactions: Quincke's edema, hives, exanthema, photosensitivity.
CONTRAINDICATIONS
- Pregnancy;
- lactation period;
- an angle-closure glaucoma;
- Benign prostatic hyperplasia, urinary retention;
- predisposition to edema;
- hypersensitivity to the drug;
- simultaneous use with MAO inhibitors;
- Children under 6 months.
PREGNANCY AND LACTATION
The drug is contraindicated during pregnancy and lactation (breastfeeding).
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
The dose of Peritol for the treatment of patients with impaired liver function should be reduced.
APPLICATION FOR CHILDREN
Children up to 6 months. the drug is contraindicated.
Children aged 6 to 24 months Peritol prescribed in a dose of 0.4 mg / kg of body weight per day.
For children aged 2 to 6 years, the daily dose is 6 mg / day (3 times 5 ml of syrup), the maximum daily dose of 8 mg.
Children suffering from anorexia are prescribed from 6 mg to 8 mg Peritol per day.
For children aged 7 to 14 years, Peritol is prescribed in a dose of 12 mg / day (3 times / day for 10 ml of syrup).
APPLICATION IN ELDERLY PATIENTS
For elderly patients during treatment with Peritol it is recommended to conduct systematic observation.
SPECIAL INSTRUCTIONS
Treatment of the elderly and children requires special attention, because this group of patients is more sensitive to the side effects of antihistamines.
Caution should also be observed when treating Peritol patients suffering from cardiovascular diseases, as well as in the presence of an anamnesis of bronchial asthma, hyperthyroidism or hypertension.
Drinking alcohol during treatment with Peritolum is contraindicated.
Influence on ability of driving of vehicles and management of mechanisms:
Patients during treatment with peritol should refrain from driving vehicles and managing equipment, as well as performing work associated with increased risk.
OVERDOSE
Overdose Peritol may be accompanied by both oppression and CNS stimulation, up to the development of seizures and death, especially in infants and children.Possible the development of atropine-like effects and a violation of the function of the gastrointestinal tract. In children: mydriasis and the immobility of the pupils, hyperemia of the facial skin, vascular collapse, coma. In adults: inhibition, depression, coma, psychomotor agitation, convulsions; hyperthermia, skin hyperemia.
Treatment: gastric lavage, activated charcoal; when treating patients who are consciously vomiting does not arise spontaneously, it is caused by ipecacuanas. If vomiting can not be caused, a gastric lavage is performed with an isotonic or semi-isotonic sodium chloride solution followed by the administration of activated carbon. Saline laxatives have a rapid effect, increasing osmotic pressure in the intestines and delaying the absorption of the drug.
In case of threatening symptoms, the CNS and other organs should be treated accordingly. You should use CNS stimulants, as well as vasopressor drugs to eliminate arterial hypotension.
DRUG INTERACTION
Combined use of cyproheptadine with fluoxetine and other inhibitors of reverse neuronal seizure of serotonin leads to a decrease in the effectiveness of antidepressants.
Caffeine reduces the depressant effect of peritol on the central nervous system.
Additive effect can be observed with the combined use of Peritol with ethanol and other substances that depress the central nervous system (sedatives, hypnotics, anxiolytics).
Simultaneous use of Peritol with other drugs that depress the central nervous system requires constant monitoring of the patient and withdrawal of the drug if necessary.
Contraindicated concurrent use of Peritol with MAO inhibitors. MAO inhibitors, as well as tricyclic antidepressants, can prolong and intensify the m-holin-blocking effect of cyproheptadine, and enhance the inhibitory effect on the CNS.
TERMS OF RELEASE FROM PHARMACY
It is released on prescription.
TERMS AND CONDITIONS OF STORAGE
Store the drug at a temperature of 15-25 В° C. Keep out of the reach of children! Shelf life - 3 years.
